Q5JTZ9: Alanine--tRNA ligase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03133}
Protein names | - Alanine--tRNA ligase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03133} - 6.1.1.7 {ECO:0000255|HAMAP-Rule:MF_03133} - Alanyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_03133} - AlaRS {ECO:0000255|HAMAP-Rule:MF_03133} |
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Gene names | AARS2 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q5JTZ9 |
4
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAASVAAAAR RLRRAIRRSP AWRGLSHRPL SSEPPAAKAS AVRAAFLNFF RDRHGHRLVP
70 80 90 100 110 120
SASVRPRGDP SLLFVNAGMN QFKPIFLGTV DPRSEMAGFR RVANSQKCVR AGGHHNDLED
130 140 150 160 170 180
VGRDLSHHTF FEMLGNWAFG GEYFKEEACN MAWELLTQVY GIPEERLWIS YFDGDPKAGL
190 200 210 220 230 240
DPDLETRDIW LSLGVPASRV LSFGPQENFW EMGDTGPCGP CTEIHYDLAG GVGAPQLVEL
250 260 270 280 290 300
WNLVFMQHNR EADGSLQPLP QRHVDTGMGL ERLVAVLQGK HSTYDTDLFS PLLNAIQQGC
310 320 330 340 350 360
RAPPYLGRVG VADEGRTDTA YRVVADHIRT LSVCISDGIF PGMSGPPLVL RRILRRAVRF
370 380 390 400 410 420
SMEILKAPPG FLGSLVPVVV ETLGDAYPEL QRNSAQIANL VSEDEAAFLA SLERGRRIID
430 440 450 460 470 480
RTLRTLGPSD MFPAEVAWSL SLCGDLGLPL DMVELMLEEK GVQLDSAGLE RLAQEEAQHR
490 500 510 520 530 540
ARQAEPVQKQ GLWLDVHALG ELQRQGVPPT DDSPKYNYSL RPSGSYEFGT CEAQVLQLYT
550 560 570 580 590 600
EDGTAVASVG KGQRCGLLLD RTNFYAEQGG QASDRGYLVR AGQEDVLFPV ARAQVCGGFI
610 620 630 640 650 660
LHEAVAPECL RLGDQVQLHV DEAWRLGCMA KHTATHLLNW ALRQTLGPGT EQQGSHLNPE
670 680 690 700 710 720
QLRLDVTTQT PLTPEQLRAV ENTVQEAVGQ DEAVYMEEVP LALTAQVPGL RSLDEVYPDP
730 740 750 760 770 780
VRVVSVGVPV AHALDPASQA ALQTSVELCC GTHLLRTGAV GDLVIIGDRQ LSKGTTRLLA
790 800 810 820 830 840
VTGEQAQQAR ELGQSLAQEV KAATERLSLG SRDVAEALRL SKDIGRLIEA VETAVMPQWQ
850 860 870 880 890 900
RRELLATVKM LQRRANTAIR KLQMGQAAKK TQELLERHSK GPLIVDTVSA ESLSVLVKVV
910 920 930 940 950 960
RQLCEQAPST SVLLLSPQPM GKVLCACQVA QGAMPTFTAE AWALAVCSHM GGKAWGSRVV
970 980
AQGTGSTTDL EAALSIAQTY ALSQL
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q5JTZ9-24-unknown | GLSHRP... | 24 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q5JTZ9-26- | SHRPLS... | 26 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q5JTZ9-26- | SHRPLS... | 26 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q5JTZ9-26- | SHRPLS... | 26 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q5JTZ9-26- | SHRPLS... | 26 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q5JTZ9-26- | SHRPLS... | 26 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q5JTZ9-26- | SHRPLS... | 26 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
Q5JTZ9-26- | SHRPLS... | 26 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q5JTZ9-26-unknown | SHRPLS... | 26 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q5JTZ9-26-unknown | SHRPLS... | 26 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q5JTZ9-692-unknown | EAVYME... | 692 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12484 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AVGQDE | 691 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12484 | |||
...ALSQL | 985 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 691 | GQDE.|.EAVY | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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