Q5PRF9: Protein Smaug homolog 2

General Information

Protein names	- Protein Smaug homolog 2 - Smaug 2 - hSmaug2 - Sterile alpha motif domain-containing protein 4B - SAM domain-containing protein 4B
Gene names	SAMD4B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5PRF9

4 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMFRDQVGIL AGWFKGWNEC EQTVALLSLL KRVTRTQARF LQLCLEHSLA DCNDIHLLES
        70         80         90        100        110        120
EANSAAIVSQ WQQESKEKVV SLLLSHLPLL QPGNTEAKSE YMRLLQKVLA YSIESNAFIE
       130        140        150        160        170        180
ESRQLLSYAL IHPATTLEDR NALALWLSHL EERLASGFRS RPEPSYHSRQ GSDEWGGPAE
       190        200        210        220        230        240
LGPGEAGPGW QDKPPRENGH VPFHPSSSVP PAINSIGSNA NTGLPCQIHP SPLKRSMSLI
       250        260        270        280        290        300
PTSPQVPGEW PSPEELGARA AFTTPDHAPL SPQSSVASSG SEQTEEQGSS RNTFQEDGSG
       310        320        330        340        350        360
MKDVPSWLKS LRLHKYAALF SQMSYEEMMT LTEQHLESQN VTKGARHKIA LSIQKLRERQ
       370        380        390        400        410        420
SVLKSLEKDV LEGGNLRNAL QELQQIIITP IKAYSVLQAT VAAATTTPTA KDGAPGEPPL
       430        440        450        460        470        480
PGAEPPLAHP GTDKGTEAKD PPAVENYPPP PAPAPTDGSE PAPAPVADGD IPSQFTRVMG
       490        500        510        520        530        540
KVCTQLLVSR PDEENITSYL QLIEKCLTHE AFTETQKKRL LSWKQQVLKL LRTFPRKAAL
       550        560        570        580        590        600
EMQNYRQQKG WAFGSNSLPI AGSVGMGVAR RTQRQFPMPP RALPPGRMGL LSPSGIGGVS
       610        620        630        640        650        660
PRHALTSPSL GGQGRQNLWF ANPGGSNSMP SQSRSSVQRT HSLPVHSSPQ AILMFPPDCP
       670        680        690
VPGPDLEINP TLESLCLSMT EHALGDGTDK TSTI

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5PRF9-1-unknown	MMFRDQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5PRF9-215-	SIGSNA...	215		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q5PRF9-274-unknown	SSVASS...	274	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14562
Q5PRF9-413-	GAPGEP...	413		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q5PRF9-413-	GAPGEP...	413		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WQQESK	75	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469404
...SIGSNA	219	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469620
...PLSPQS	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14562
...HLESQN	339	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470821
...KTSTI	694	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	273	SPQS.\|.SSVA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)