Q5QNW6: Histone H2B type 2-F

General Information

Protein names	- Histone H2B type 2-F
Gene names	HIST2H2BF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5QNW6

15 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPDPAKSAPA PKKGSKKAVT KVQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
        70         80         90        100        110        120
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT

KYTSSK

Isoforms

- Isoform 2 of Histone H2B type 2-F

Sequence View

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Protein Neighborhood

Domains & Features

15 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5QNW6-2-unknown	MPDPAK...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q5QNW6-2-unknown	MPDPAK...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q5QNW6-2-unknown	MPDPAK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5QNW6-1-unknown	MPDPAK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76700
Q5QNW6-2-Acetylation	PDPAKS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5QNW6-2-Acetylation	PDPAKS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110116
Q5QNW6-2-Acetylation	PDPAKS...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q5QNW6-7-unknown	SAPAPK...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177917
Q5QNW6-7-	SAPAPK...	7			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q5QNW6-18-unknown	AVTKVQ...	18		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166772
Q5QNW6-18-	AVTKVQ...	18			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q5QNW6-18-	AVTKVQ...	18			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q5QNW6-45-	VLKQVH...	45			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q5QNW6-45-unknown	VLKQVH...	45		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166776
Q5QNW6-53-unknown	TGISSK...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12485
Q5QNW6-53-unknown	TGISSK...	53		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139422
Q5QNW6-59-unknown	AMGIMN...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10336
Q5QNW6-59-unknown	AMGIMN...	59		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139817
Q5QNW6-59-unknown	AMGIMN...	59		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5QNW6-59-unknown	AMGIMN...	59		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q5QNW6-65-unknown	SFVNDI...	65		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166774
Q5QNW6-65-	SFVNDI...	65			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q5QNW6-110-	HAVSEG...	110			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q5QNW6-111-	AVSEGT...	111			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q5QNW6-111-	AVSEGT...	111			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVHPDT	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12485
...QVHPDT	52	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122507
...GISSKA	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10336
...GISSKA	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122916
...YTSSK	126	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YTSSK	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91602

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	52	HPDT.\|.TGIS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	58	SSKA.\|.AMGI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)