Q5T0F9: Coiled-coil and C2 domain-containing protein 1B

General Information

Protein names	- Coiled-coil and C2 domain-containing protein 1B - Five prime repressor element under dual repression-binding protein 2 - FRE under dual repression-binding protein 2 - Freud-2
Gene names	CC2D1B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5T0F9

12 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Coiled-coil and C2 domain-containing protein 1B - Isoform 3 of Coiled-coil and C2 domain-containing protein 1B - Isoform 4 of Coiled-coil and C2 domain-containing protein 1B - Isoform 5 of Coiled-coil and C2 domain-containing protein 1B

Sequence View

        10         20         30         40         50         60
MMPGPRPRKG PQARGQGVAA AKQMGLFMEF GPEDMLLGMD EAEDDEDLEA ELLALTGEAQ
        70         80         90        100        110        120
TTGKKPAPKG QAPLPMAHIE KLAADCMRDV EEEEEEEGLE EDAELLTELQ EVLGVDEETE
       130        140        150        160        170        180
PLDGDEVADP GGSEEENGLE DTEPPVQTAV LTASAPAAQA GASQGLHALL EERIHNYREA
       190        200        210        220        230        240
AASAKEAGEA AKARRCERGL KTLESQLASV RRGRKINEDE IPPPVALGKR PLAPQEPANR
       250        260        270        280        290        300
SPETDPPAPP ALESDNPSQP ETSLPGISAQ PVSDLDPDPR ALLSSRQREY KVAALSAKRA
       310        320        330        340        350        360
GELDRARELM RIGKRFGAVL EALEKGQPVD LSAMPPAPED LKPQQASQAP TAPSVIPPAV
       370        380        390        400        410        420
ERVQPVMAPD VPATPVAPTE SQTVLDALQQ RLNKYREAGI QARSGGDERK ARMHERIAKQ
       430        440        450        460        470        480
YQDAIRAHRA GRKVNFAELP VPPGFPPIPG LESTMGVEED AVAATLAAAE KLASAEDSAP
       490        500        510        520        530        540
ADKDEDEPPG HLQGEPPAQA PVAKKPARPT VPSSQRLPEP RASSSKESPS PSVREQLALL
       550        560        570        580        590        600
EARKLQYQRA ALQAKRSQDL EQAKAYLRVA KWLEAQIIQA RSGRPVDLSK VPSPLTDEEG
       610        620        630        640        650        660
DFILIHHEDL RLSQKAEEVY AQLQKMLLEQ QEKCLLFSKQ FMHQGNVAET TRFEKLAQDR
       670        680        690        700        710        720
KKQLEILQLA QAQGLDPPTH HFELKTFQTV RIFSELNSTE MHLIIVRGMN LPAPPGVTPD
       730        740        750        760        770        780
DLDAFVRFEF HYPNSDQAQK SKTAVVKNTN SPEFDQLFKL NINRNHRGFK RVIQSKGIKF
       790        800        810        820        830        840
EIFHKGSFFR SDKLVGTAHL KLERLENECE IREIVEVLDG RKPTGGKLEV KVRLREPLSG
       850
QDVQMVTENW LVLEPRGL         10         20         30         40         50         60
MMPGPRPRKG PQARGQGVAA AKQMGLFMEF GPEDMLLGMD EAEDDEDLEA ELLALTGEAQ
        70         80         90        100        110        120
TTGKKPAPKG QAPLPMAHIE KLAADCMRDV EEEEEEEGLE EDAELLTELQ EVLGVDEETE
       130        140        150        160        170        180
PLDGDEVADP GGSEEENGLE DTEPPVQTAV LTASAPAAQA GASQGLHALL EERIHNYREA
       190        200        210        220        230        240
AASAKEAGEA AKARRCERGL KTLESQLASV RRGRKINEDE IPPPVALGKR PLAPQEPANR
       250        260        270        280        290        300
SPETDPPAPP ALESDNPSQP ETSLPGISAQ PVSDLDPDPR ALLSSRQREY KVAALSAKRA
       310        320        330        340        350        360
GELDRARELM RIGKRFGAVL EALEKGQPVD LSAMPPAPED LKPQQASQAP TAPSVIPPAV
       370        380        390        400        410        420
ERVQPVMAPD VPATPVAPTE SQTVLDALQQ RLNKYREAGI QARSGGDERK ARMHERIAKQ
       430        440        450        460        470        480
YQDAIRAHRA GRKVNFAELP VPPGFPPIPG LESTMGVEED AVAATLAAAE KLASAEDSAP
       490        500        510        520        530        540
ADKDEDEPPG HLQGEPPAQA PVAKKPARPT VPSSQRLPEP RASSSKESPS PSVREQLALL
       550        560        570        580        590        600
EARKLQYQRA ALQAKRSQDL EQAKAYLRVA KWLEAQIIQA RSGRPVDLSK VPSPLTDEEG
       610        620        630        640        650        660
DFILIHHEDL RLSQKAEEVY AQLQKMLLEQ QEKCLLFSKQ FMHQGNVAET TRFEKLAQDR
       670        680        690        700        710        720
KKQLEILQLA QAQGLDPPTH HFELKTFQTV RIFSELNSTE MHLIIVRGMN LPAPPGVTPD
       730        740        750        760        770        780
DLDAFVRFEF HYPNSDQAQK SKTAVVKNTN SPEFDQLFKL NINRNHRGFK RVIQSKGIKF
       790        800        810        820        830        840
EIFHKGSFFR SDKLVGTAHL KLERLENECE IREIVEVLDG RKPTGGKLEV KVRLREPLSG
       850
QDVQMVTENW LVLEPRGL         10         20         30         40         50         60
MMPGPRPRKG PQARGQGVAA AKQMGLFMEF GPEDMLLGMD EAEDDEDLEA ELLALTGEAQ
        70         80         90        100        110        120
TTGKKPAPKG QAPLPMAHIE KLAADCMRDV EEEEEEEGLE EDAELLTELQ EVLGVDEETE
       130        140        150        160        170        180
PLDGDEVADP GGSEEENGLE DTEPPVQTAV LTASAPAAQA GASQGLHALL EERIHNYREA
       190        200        210        220        230        240
AASAKEAGEA AKARRCERGL KTLESQLASV RRGRKINEDE IPPPVALGKR PLAPQEPANR
       250        260        270        280        290        300
SPETDPPAPP ALESDNPSQP ETSLPGISAQ PVSDLDPDPR ALLSSRQREY KVAALSAKRA
       310        320        330        340        350        360
GELDRARELM RIGKRFGAVL EALEKGQPVD LSAMPPAPED LKPQQASQAP TAPSVIPPAV
       370        380        390        400        410        420
ERVQPVMAPD VPATPVAPTE SQTVLDALQQ RLNKYREAGI QARSGGDERK ARMHERIAKQ
       430        440        450        460        470        480
YQDAIRAHRA GRKVNFAELP VPPGFPPIPG LESTMGVEED AVAATLAAAE KLASAEDSAP
       490        500        510        520        530        540
ADKDEDEPPG HLQGEPPAQA PVAKKPARPT VPSSQRLPEP RASSSKESPS PSVREQLALL
       550        560        570        580        590        600
EARKLQYQRA ALQAKRSQDL EQAKAYLRVA KWLEAQIIQA RSGRPVDLSK VPSPLTDEEG
       610        620        630        640        650        660
DFILIHHEDL RLSQKAEEVY AQLQKMLLEQ QEKCLLFSKQ FMHQGNVAET TRFEKLAQDR
       670        680        690        700        710        720
KKQLEILQLA QAQGLDPPTH HFELKTFQTV RIFSELNSTE MHLIIVRGMN LPAPPGVTPD
       730        740        750        760        770        780
DLDAFVRFEF HYPNSDQAQK SKTAVVKNTN SPEFDQLFKL NINRNHRGFK RVIQSKGIKF
       790        800        810        820        830        840
EIFHKGSFFR SDKLVGTAHL KLERLENECE IREIVEVLDG RKPTGGKLEV KVRLREPLSG
       850
QDVQMVTENW LVLEPRGL         10         20         30         40         50         60
MMPGPRPRKG PQARGQGVAA AKQMGLFMEF GPEDMLLGMD EAEDDEDLEA ELLALTGEAQ
        70         80         90        100        110        120
TTGKKPAPKG QAPLPMAHIE KLAADCMRDV EEEEEEEGLE EDAELLTELQ EVLGVDEETE
       130        140        150        160        170        180
PLDGDEVADP GGSEEENGLE DTEPPVQTAV LTASAPAAQA GASQGLHALL EERIHNYREA
       190        200        210        220        230        240
AASAKEAGEA AKARRCERGL KTLESQLASV RRGRKINEDE IPPPVALGKR PLAPQEPANR
       250        260        270        280        290        300
SPETDPPAPP ALESDNPSQP ETSLPGISAQ PVSDLDPDPR ALLSSRQREY KVAALSAKRA
       310        320        330        340        350        360
GELDRARELM RIGKRFGAVL EALEKGQPVD LSAMPPAPED LKPQQASQAP TAPSVIPPAV
       370        380        390        400        410        420
ERVQPVMAPD VPATPVAPTE SQTVLDALQQ RLNKYREAGI QARSGGDERK ARMHERIAKQ
       430        440        450        460        470        480
YQDAIRAHRA GRKVNFAELP VPPGFPPIPG LESTMGVEED AVAATLAAAE KLASAEDSAP
       490        500        510        520        530        540
ADKDEDEPPG HLQGEPPAQA PVAKKPARPT VPSSQRLPEP RASSSKESPS PSVREQLALL
       550        560        570        580        590        600
EARKLQYQRA ALQAKRSQDL EQAKAYLRVA KWLEAQIIQA RSGRPVDLSK VPSPLTDEEG
       610        620        630        640        650        660
DFILIHHEDL RLSQKAEEVY AQLQKMLLEQ QEKCLLFSKQ FMHQGNVAET TRFEKLAQDR
       670        680        690        700        710        720
KKQLEILQLA QAQGLDPPTH HFELKTFQTV RIFSELNSTE MHLIIVRGMN LPAPPGVTPD
       730        740        750        760        770        780
DLDAFVRFEF HYPNSDQAQK SKTAVVKNTN SPEFDQLFKL NINRNHRGFK RVIQSKGIKF
       790        800        810        820        830        840
EIFHKGSFFR SDKLVGTAHL KLERLENECE IREIVEVLDG RKPTGGKLEV KVRLREPLSG
       850
QDVQMVTENW LVLEPRGL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5T0F9-1-unknown	MMPGPR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5T0F9-1-unknown	MMPGPR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68831
Q5T0F9-1-unknown	MMPGPR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68834
Q5T0F9-26-unknown	LFMEFG...	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12500
Q5T0F9-26-unknown	LFMEFG...	26	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137297
Q5T0F9-26-unknown	LFMEFG...	26	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137298
Q5T0F9-154-unknown	SAPAAQ...	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167740
Q5T0F9-154-	SAPAAQ...	154		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q5T0F9-154-	SAPAAQ...	154		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q5T0F9-258-	SQPETS...	258		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q5T0F9-258-unknown	SQPETS...	258	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175206
Q5T0F9-310-unknown	MRIGKR...	310	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68832
Q5T0F9-310-unknown	MRIGKR...	310	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108352
Q5T0F9-373-unknown	ATPVAP...	373	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165153
Q5T0F9-373-unknown	ATPVAP...	373	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165154
Q5T0F9-373-	ATPVAP...	373		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q5T0F9-373-	ATPVAP...	373		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q5T0F9-461-unknown	AVAATL...	461	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171613
Q5T0F9-461-unknown	AVAATL...	461	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171614
Q5T0F9-461-	AVAATL...	461		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q5T0F9-626-unknown	MLLEQQ...	626	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68833
Q5T0F9-626-unknown	MLLEQQ...	626	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108394
Q5T0F9-626-unknown	MLLEQQ...	626	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108395

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AKQMGL	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12500
...AKQMGL	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120230
...AKQMGL	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120231
...EPRGL	858	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EPRGL	858	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64449

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	25	QMGL.\|.LFME	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)