Q5T3I0: G patch domain-containing protein 4

General Information

Protein names	- G patch domain-containing protein 4
Gene names	GPATCH4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5T3I0

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of G patch domain-containing protein 4 - Isoform 3 of G patch domain-containing protein 4

Sequence View

        10         20         30         40         50         60
MNVTPEVKSR GMKFAEEQLL KHGWTQGKGL GRKENGITQA LRVTLKQDTH GVGHDPAKEF
        70         80         90        100        110        120
TNHWWNELFN KTAANLVVET GQDGVQIRSL SKETTRYNHP KPNLLYQKFV KMATLTSGGE
       130        140        150        160        170        180
KPNKDLESCS DDDNQGSKSP KILTDEMLLQ ACEGRTAHKA ARLGITMKAK LARLEAQEQA
       190        200        210        220        230        240
FLARLKGQDP GAPQLQSESK PPKKKKKKRR QKEEEEATAS ERNDADEKHP EHAEQNIRKS
       250        260        270        280        290        300
KKKKRRHQEG KVSDEREGTT KGNEKEDAAG TSGLGELNSR EQTNQSLRKG KKKKRWHHEE
       310        320        330        340        350        360
EKMGVLEEGG KGKEAAGSVR TEEVESRAYA DPCSRRKKRQ QQEEEDLNLE DRGEETVLGG
       370        380        390        400        410        420
GTREAESRAC SDGRSRKSKK KRQQHQEEED ILDVRDEKDG GAREAESRAH TGSSSRGKRK
       430        440
RQQHPKKERA GVSTVQKAKK KQKKRD         10         20         30         40         50         60
MNVTPEVKSR GMKFAEEQLL KHGWTQGKGL GRKENGITQA LRVTLKQDTH GVGHDPAKEF
        70         80         90        100        110        120
TNHWWNELFN KTAANLVVET GQDGVQIRSL SKETTRYNHP KPNLLYQKFV KMATLTSGGE
       130        140        150        160        170        180
KPNKDLESCS DDDNQGSKSP KILTDEMLLQ ACEGRTAHKA ARLGITMKAK LARLEAQEQA
       190        200        210        220        230        240
FLARLKGQDP GAPQLQSESK PPKKKKKKRR QKEEEEATAS ERNDADEKHP EHAEQNIRKS
       250        260        270        280        290        300
KKKKRRHQEG KVSDEREGTT KGNEKEDAAG TSGLGELNSR EQTNQSLRKG KKKKRWHHEE
       310        320        330        340        350        360
EKMGVLEEGG KGKEAAGSVR TEEVESRAYA DPCSRRKKRQ QQEEEDLNLE DRGEETVLGG
       370        380        390        400        410        420
GTREAESRAC SDGRSRKSKK KRQQHQEEED ILDVRDEKDG GAREAESRAH TGSSSRGKRK
       430        440
RQQHPKKERA GVSTVQKAKK KQKKRD

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5T3I0-1-Acetylation	MNVTPE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5T3I0-1-Acetylation	MNVTPE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q5T3I0-1-Acetylation	MNVTPE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q5T3I0-146-unknown	EMLLQA...	146		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12503
Q5T3I0-146-unknown	EMLLQA...	146		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144796
Q5T3I0-211-unknown	QKEEEE...	211		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10346
Q5T3I0-211-unknown	QKEEEE...	211		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147197

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KILTDE	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12503
...KILTDE	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128071
...KKKRRQ	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10346
...KKKRRQ	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130537
...QKKRD	446	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QKKRD	446	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71988

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	145	LTDE.\|.EMLL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	210	KRRQ.\|.QKEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)