Q5VT06: Centrosome-associated protein 350 {ECO:0000305}

General Information

Protein names	- Centrosome-associated protein 350 {ECO:0000305} - Cep350 - Centrosome-associated protein of 350 kDa {ECO:0000303\|Ref.1}
Gene names	CEP350
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5VT06

6 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRSSKSKEVP LPNPRNSQSK DTVQADITTS WDALSQTKAA LRHIENKLEV APTSTAVCDS
        70         80         90        100        110        120
VMDTKKSSTS ATRKISRKDG RYLDDSWVNA PISKSTKSRK EKSRSPLRAT TLESNVKKNN
       130        140        150        160        170        180
RVEFREPLVS YREIHGAPSN FSSSHLESKH VYCVDVNEEK TESGNWMIGS REERNIRSCD
       190        200        210        220        230        240
FESSQSSVIN DTVVRFLNDR PAIDALQNSE CLIRMGASMR TEEEMPNRTK GSENNLKLSV
       250        260        270        280        290        300
NNMAHDTDPK ALRLTDSSPS STSTSNSQRL DILKRRQHDV KLEKLKERIR KQWEHSEETN
       310        320        330        340        350        360
GRGQKLGHID HPVMVVNVDN SVTAKVRKVA TAPPAPAYKG FNPSETKIRT PDGKVWQEAE
       370        380        390        400        410        420
FQNMSRELYR DLALHFADDI SIKEKPAEKS KEKKVVKPVR KVQKVAQLSS TECRTGSSHL
       430        440        450        460        470        480
ISTSSWRDGQ KLVKKILGPA PRMEPKEQRT ASSDRGGRER TAKSGGHIGR AESDPRLDVL
       490        500        510        520        530        540
HRHLQRNSER SRSKSRSENN IKKLASSLPD NKQEENTALN KDFLPIEIRG ILDDLQLDST
       550        560        570        580        590        600
AHTAKQDTVE LQNQKSSAPV HAPRSHSPVK RKPDKITANE DPPVISKRRH YDTDEVRQYI
       610        620        630        640        650        660
VRQQEERKRK QNEEKKAQKE ATEQKNKRLQ ELYRKQKEAF TKVKNVPPSE PSATRRLQET
       670        680        690        700        710        720
YSKLLLEKTL LEEPSHQHVT QETQAKPGYQ PSGESDKENK VQERPPSASS SSDMSLSEPP
       730        740        750        760        770        780
QPLARKDLME STWMQPERLS PQVHHSQPQP FAGTAGSLLS HLLSLEHVGI LHKDFESILP
       790        800        810        820        830        840
TRKNHNMASR PLTFTPQPYV TSPAAYTDAL LKPSASQYKS KLDRIEALKA TAASLSSRIE
       850        860        870        880        890        900
SEAKKLAGAS INYGSAWNTE YDVQQAPQED GPWTKAVTPP VKDDNEDVFS ARIQKMLGSC
       910        920        930        940        950        960
VSHATFDDDL PGVGNLSEFK KLPEMIRPQS AISSFRVRSP GPKPEGLLAQ LCKRQTDSSS
       970        980        990       1000       1010       1020
SDMQACSQDK AKISLGSSID SVSEGPLLSE GSLSEEEGDQ DGQPLLKVAE ILKEKEFCPG
      1030       1040       1050       1060       1070       1080
ERNSYEPIKE FQKEAEKFLP LFGHIGGTQS KGPWEELAKG SPHSVINIFT KSYQLYGKGF
      1090       1100       1110       1120       1130       1140
EDKLDRGTST SRPLNATATP LSGVSYEDDF VSSPGTGTST EKKSTLEPHS TLSPQEDHSN
      1150       1160       1170       1180       1190       1200
RKSAYDPSSV DVTSQHSSGA QSAASSRSST SSKGKKGKKE KTEWLDSFTG NVQNSLLDEE
      1210       1220       1230       1240       1250       1260
KAERGSHQGK KSGTSSKLSV KDFEQTLDTD STLEDLSGHS VSVSSDKGRS QKTPTSPLSP
      1270       1280       1290       1300       1310       1320
SSQKSLQFDV AGTSSERSKS SVMPPTITGF KPNAPLTDLN PAASRTTTEN MAPIPGSKRF
      1330       1340       1350       1360       1370       1380
SPAGLHHRMA AELSYLNAIE ESVRQLSDVE RVRGISLAQQ ESVSLAQIIK AQQQRHERDL
      1390       1400       1410       1420       1430       1440
ALLKLKAEQE ALESQRQLEE TRNKAAQVHA ESLQQVVQSQ REVTEVLQEA TCKIAAQQSE
      1450       1460       1470       1480       1490       1500
TARLTTDAAR QICEMAELTR THISDAVVAS GAPLAILYDH QRQHLPDFVK QLRTRTETDR
      1510       1520       1530       1540       1550       1560
KSPSVSLSQS KEGTLDSKHQ KYSASYDSYS ESSGYKNHDR RSSSGSSRQE SPSVPSCKEN
      1570       1580       1590       1600       1610       1620
EKKLNGEKIE SSIDEQVQTA ADDSLRSDSV PSLPDEKDST SIATEYSLKF DESMTEDEIE
      1630       1640       1650       1660       1670       1680
EQSFRSLLPS ESHRRFNMEK RRGHHDDSDE EASPEKTTLS TAKELNMPFS GGQDSFSKFT
      1690       1700       1710       1720       1730       1740
MEMVRQYMKE EEMRAAHQSS LLRLREKALK EKTKAELAWL EHQKKHLRDK GEDDKMPPLR
      1750       1760       1770       1780       1790       1800
KKQRGLLLRL QQEKAEIKRL QEANKAARKE RQLILKQQEE IEKIRQTTIK LQEKLKSAGE
      1810       1820       1830       1840       1850       1860
SKLDSHSDDD TKDNKATSPG PTDLETRSPS PISISSSETS SIMQKLKKMR SRMDEKFLTK
      1870       1880       1890       1900       1910       1920
REQKLMQRRQ HAEELLEWKR RLDAEEAEIR QMEKQALAAW DKELIKPKTP KKELEDQRTE
      1930       1940       1950       1960       1970       1980
QKEIASEEES PVPLYSHLNS ESSIPEELGS PAVEYVPSES IGQEQPGSPD HSILTEEMIC
      1990       2000       2010       2020       2030       2040
SQELESSTSP SKHSLPKSCT SVSKQESSKG SHRTGGQCHL PIKSHQHCYS WSDESLSMTQ
      2050       2060       2070       2080       2090       2100
SETTSDQSDI EGRIRALKDE LRKRKSVVNQ LKKEQKKRQK ERLKAQEASL IKQLESYDEF
      2110       2120       2130       2140       2150       2160
IKKTEAELSQ DLETSPTAKP QIKTLSSASE KPKIKPLTPL HRSETAKNWK SLTESERSRG
      2170       2180       2190       2200       2210       2220
SLESIAEHVD ASLSGSERSV SERSLSAYAK RVNEWDSRTE DFQTPSPVLR SSRKIREESG
      2230       2240       2250       2260       2270       2280
DSLENVPALH LLKELNATSR ILDMSDGKVG ESSKKSEIKE IEYTKLKKSK IEDAFSKEGK
      2290       2300       2310       2320       2330       2340
SDVLLKLVLE QGDSSEILSK KDLPLDSENV QKDLVGLAIE NLHKSEEMLK ERQSDQDMNH
      2350       2360       2370       2380       2390       2400
SPNIQSGKDI HEQKNTKEKD LSWSEHLFAP KEIPYSEDFE VSSFKKEISA ELYKDDFEVS
      2410       2420       2430       2440       2450       2460
SLLSLRKDSQ SCRDKPQPMR SSTSGATSFG SNEEISECLS EKSLSIHSNV HSDRLLELKS
      2470       2480       2490       2500       2510       2520
PTELMKSKER SDVEHEQQVT ESPSLASVPT ADELFDFHIG DRVLIGNVQP GILRFKGETS
      2530       2540       2550       2560       2570       2580
FAKGFWAGVE LDKPEGNNNG TYDGIAYFEC KEKHGIFAPP QKISHIPENF DDYVDINEDE
      2590       2600       2610       2620       2630       2640
DCYSDERYQC YNQEQNDTEG PKDREKDVSE YFYEKSLPSV NDIEASVNRS RSLKIETDNV
      2650       2660       2670       2680       2690       2700
QDISGVLEAH VHQQSSVDSQ ISSKENKDLI SDATEKVSIA AEDDTLDNTF SEELEKQQQF
      2710       2720       2730       2740       2750       2760
TEEEDNLYAE ASEKLCTPLL DLLTREKNQL EAQLKSSLNE EKKSKQQLEK ISLLTDSLLK
      2770       2780       2790       2800       2810       2820
VFVKDTVNQL QQIKKTRDEK IQLSNQELLG DDQKKVTPQD LSQNVEEQSP SISGCFLSSE
      2830       2840       2850       2860       2870       2880
LEDEKEEISS PDMCPRPESP VFGASGQEEL AKRLAELELS REFLSALGDD QDWFDEDFGL
      2890       2900       2910       2920       2930       2940
SSSHKIQKNK AEETIVPLMA EPKRVTQQPC ETLLAVPHTA EEVEILVHNA AEELWKWKEL
      2950       2960       2970       2980       2990       3000
GHDLHSISIP TKLLGCASKG LDIESTSKRV YKQAVFDLTK EIFEEIFAED PNLNQPVWMK
      3010       3020       3030       3040       3050       3060
PCRINSSYFR RVKNPNNLDE IKSFIASEVL KLFSLKKEPN HKTDWQKMMK FGRKKRDRVD
      3070       3080       3090       3100       3110
HILVQELHEE EAQWVNYDED ELCVKMQLAD GIFETLIKDT IDVLNQISEK QGRMLLV

Isoforms

Sequence View

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Directness:

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Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5VT06-1-unknown	MRSSKS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5VT06-539-	STAHTA...	539		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q5VT06-539-	STAHTA...	539		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q5VT06-981-	SVSEGP...	981		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q5VT06-981-	SVSEGP...	981		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q5VT06-1994-unknown	SLPKSC...	1994	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409395
Q5VT06-2487-	SVPTAD...	2487		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q5VT06-2487-	SVPTAD...	2487		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q5VT06-2487-	SVPTAD...	2487		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q5VT06-2487-	SVPTAD...	2487		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q5VT06-2537-unknown	NNNGTY...	2537	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000401608

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PLVSYR	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000350016
...TSNSQR	268	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435808
...YMKEEE	1691	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407044
...RMLLV	3117	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)