Q5VYK3: Proteasome adapter and scaffold protein ECM29 {ECO:0000305}

General Information

Protein names	- Proteasome adapter and scaffold protein ECM29 {ECO:0000305} - Ecm29 proteasome adapter and scaffold {ECO:0000312\|HGNC:HGNC:29020} - Proteasome-associated protein ECM29 homolog
Gene names	ECM29
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5VYK3

6 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAAASASQ DELNQLERVF LRLGHAETDE QLQNIISKFL PPVLLKLSST QEGVRKKVME
        70         80         90        100        110        120
LLVHLNKRIK SRPKIQLPVE TLLVQYQDPA AVSFVTNFTI IYVKMGYPRL PVEKQCELAP
       130        140        150        160        170        180
TLLTAMEGKP QPQQDSLMHL LIPTLFHMKY PVESSKSASP FNLAEKPKTV QLLLDFMLDV
       190        200        210        220        230        240
LLMPYGYVLN ESQSRQNSSS AQGSSSNSGG GSGIPQPPPG MSFYAAKRVI GDNPWTPEQL
       250        260        270        280        290        300
EQCKLGIVKF IEAEQVPELE AVLHLVIASS DTRHSVATAA DLELKSKQSL IDWNNPAIIN
       310        320        330        340        350        360
KMYKVYLGDI PLKTKEGAVL KPELKRDPVS TRVKLKIVPH LLRSRQAAET FPANIQVVYD
       370        380        390        400        410        420
GLFGTNTNSK LRTLSLQFVH HICITCPEIK IKPLGPMLLN GLTKLINEYK EDPKLLSMAY
       430        440        450        460        470        480
SAVGKLSSRM PHLFTKDIAL VQQLFEALCK EEPETRLAIQ EALSMMVGAY STLEGAQRTL
       490        500        510        520        530        540
MEALVASYLI KPEVQVRQVA VKFASTVFPS DHIPSRYLLL LAAGDPREEV HGEAQRVLRC
       550        560        570        580        590        600
LPGRNRKEST SEQMPSFPEM VYYIQEKASH RMKTPVKYMT GTTVLPFNPA AFGEIVLYLR
       610        620        630        640        650        660
MCLAHSAGVV PTSQSLADMQ DHAPAIGRYI RTLMSSGQMA PSSSNKSGET NPVQIYIGLL
       670        680        690        700        710        720
QQLLAGVGGL PVMYCLLEAV SVYPEKLATK FVDKTEWIKS LMNNSKEEMR ELAALFYSVV
       730        740        750        760        770        780
VSTVSGNELK SMIEQLIKTT KDNHSPEIQH GSLLALGFTV GRYLAKKKMR MSEQQDLERN
       790        800        810        820        830        840
ADTLPDQEEL IQSATETIGS FLDSTSPLLA IAACTALGEI GRNGPLPIPS EGSGFTKLHL
       850        860        870        880        890        900
VESLLSRIPS SKETNKMKER AIQTLGYFPV GDGDFPHQKL LLQGLMDSVE AKQIELQFTI
       910        920        930        940        950        960
GEAITSAAIG TSSVAARDAW QMTEEEYTPP AGAKVNDVVP WVLDVILNKH IISPNPHVRQ
       970        980        990       1000       1010       1020
AACIWLLSLV RKLSTHKEVK SHLKEIQSAF VSVLSENDEL SQDVASKGLG LVYELGNEQD
      1030       1040       1050       1060       1070       1080
QQELVSTLVE TLMTGKRVKH EVSGETVVFQ GGALGKTPDG QGLSTYKELC SLASDLSQPD
      1090       1100       1110       1120       1130       1140
LVYKFMNLAN HHAMWNSRKG AAFGFNVIAT RAGEQLAPFL PQLVPRLYRY QFDPNLGIRQ
      1150       1160       1170       1180       1190       1200
AMTSIWNALV TDKSMVDKYL KEILQDLVKN LTSNMWRVRE SSCLALNDLL RGRPLDDIID
      1210       1220       1230       1240       1250       1260
KLPEIWETLF RVQDDIKESV RKAAELALKT LSKVCVKMCD PAKGAAGQRT IAALLPCLLD
      1270       1280       1290       1300       1310       1320
KGMMSTVTEV RALSINTLVK ISKSAGAMLK PHAPKLIPAL LESLSVLEPQ VLNYLSLRAT
      1330       1340       1350       1360       1370       1380
EQEKAAMDSA RLSAAKSSPM METINMCLQY LDVSVLGELV PRLCELIRSG VGLGTKGGCA
      1390       1400       1410       1420       1430       1440
SVIVSLTTQC PQDLTPYSGK LMSALLSGLT DRNSVIQKSC AFAMGHLVRT SRDSSTEKLL
      1450       1460       1470       1480       1490       1500
QKLNGWYMEK EEPIYKTSCA LTIHAIGRYS PDVLKNHAKE VLPLAFLGMH EIADEEKSEK
      1510       1520       1530       1540       1550       1560
EECNLWTEVW QENVPGSFGG IRLYLQELIT ITQKALQSQS WKMKAQGAIA MASIAKQTSS
      1570       1580       1590       1600       1610       1620
LVPPYLGMIL TALLQGLAGR TWAGKEELLK AIACVVTACS AELEKSVPNQ PSTNEILQAV
      1630       1640       1650       1660       1670       1680
LKECSKENVK YKIVAISCAA DILKATKEDR FQEFSNIVIP LIKKNSLESS GVRTTKNEEE
      1690       1700       1710       1720       1730       1740
NEKEKELQLE YLLGAFESLG KAWPRNAETQ RCYRQELCKL MCERLKLSTW KVQLGVLQSM
      1750       1760       1770       1780       1790       1800
NAFFQGLMLL EEEHADPEAL AEILLETCKS ITYSLENKTY SSVRTEALSV IELLLKKLEE
      1810       1820       1830       1840
SKQWECLTSE CRVLLIESLA TMEPDSRPEL QEKAALLKKT LENLE

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5VYK3-2-unknown	MAAAAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5VYK3-2-Acetylation	AAAAAS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5VYK3-2-Acetylation	AAAAAS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q5VYK3-2-Acetylation	AAAAAS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q5VYK3-2-Acetylation	AAAAAS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q5VYK3-2-Acetylation	AAAAAS...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q5VYK3-872-unknown	DGDFPH...	872		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7912
Q5VYK3-1530-unknown	TITQKA...	1530		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000363504
Q5VYK3-1541-	WKMKAQ...	1541			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q5VYK3-1543-unknown	MKAQGA...	1543		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000363499

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PQPQQD	134	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000473402
...YFPVGD	871	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7912
...MDSVEA	890	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000473399
...LENLE	1845	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	871	PVGD.\|.DGDF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)