Q6NZI2: Caveolae-associated protein 1 {ECO:0000312|HGNC:HGNC:9688}
Protein names | - Caveolae-associated protein 1 {ECO:0000312|HGNC:HGNC:9688} - Cavin-1 - Polymerase I and transcript release factor |
---|---|
Gene names | PTRF |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q6NZI2 |
4
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MEDPTLYIVE RPLPGYPDAE APEPSSAGAQ AAEEPSGAGS EELIKSDQVN GVLVLSLLDK
70 80 90 100 110 120
IIGAVDQIQL TQAQLEERQA EMEGAVQSIQ GELSKLGKAH ATTSNTVSKL LEKVRKVSVN
130 140 150 160 170 180
VKTVRGSLER QAGQIKKLEV NEAELLRRRN FKVMIYQDEV KLPAKLSISK SLKESEALPE
190 200 210 220 230 240
KEGEELGEGE RPEEDAAALE LSSDEAVEVE EVIEESRAER IKRSGLRRVD DFKKAFSKEK
250 260 270 280 290 300
MEKTKVRTRE NLEKTRLKTK ENLEKTRHTL EKRMNKLGTR LVPAERREKL KTSRDKLRKS
310 320 330 340 350 360
FTPDHVVYAR SKTAVYKVPP FTFHVKKIRE GQVEVLKATE MVEVGADDDE GGAERGEAGD
370 380 390
LRRGSSPDVH ALLEITEESD AVLVDKSDSD
Isoforms
- Isoform 2 of Polymerase I and transcript release factor - Isoform 3 of Polymerase I and transcript release factor - Isoform 2 of Caveolae-associated protein 1 - Isoform 3 of Caveolae-associated protein 1Sequence View
10 20 30 40 50 60
MEDPTLYIVE RPLPGYPDAE APEPSSAGAQ AAEEPSGAGS EELIKSDQVN GVLVLSLLDK
70 80 90 100 110 120
IIGAVDQIQL TQAQLEERQA EMEGAVQSIQ GELSKLGKAH ATTSNTVSKL LEKVRKVSVN
130 140 150 160 170 180
VKTVRGSLER QAGQIKKLEV NEAELLRRRN FKVMIYQDEV KLPAKLSISK SLKESEALPE
190 200 210 220 230 240
KEGEELGEGE RPEEDAAALE LSSDEAVEVE EVIEESRAER IKRSGLRRVD DFKKAFSKEK
250 260 270 280 290 300
MEKTKVRTRE NLEKTRLKTK ENLEKTRHTL EKRMNKLGTR LVPAERREKL KTSRDKLRKS
310 320 330 340 350 360
FTPDHVVYAR SKTAVYKVPP FTFHVKKIRE GQVEVLKATE MVEVGADDDE GGAERGEAGD
370 380 390
LRRGSSPDVH ALLEITEESD AVLVDKSDSD
10 20 30 40 50 60
MEDPTLYIVE RPLPGYPDAE APEPSSAGAQ AAEEPSGAGS EELIKSDQVN GVLVLSLLDK
70 80 90 100 110 120
IIGAVDQIQL TQAQLEERQA EMEGAVQSIQ GELSKLGKAH ATTSNTVSKL LEKVRKVSVN
130 140 150 160 170 180
VKTVRGSLER QAGQIKKLEV NEAELLRRRN FKVMIYQDEV KLPAKLSISK SLKESEALPE
190 200 210 220 230 240
KEGEELGEGE RPEEDAAALE LSSDEAVEVE EVIEESRAER IKRSGLRRVD DFKKAFSKEK
250 260 270 280 290 300
MEKTKVRTRE NLEKTRLKTK ENLEKTRHTL EKRMNKLGTR LVPAERREKL KTSRDKLRKS
310 320 330 340 350 360
FTPDHVVYAR SKTAVYKVPP FTFHVKKIRE GQVEVLKATE MVEVGADDDE GGAERGEAGD
370 380 390
LRRGSSPDVH ALLEITEESD AVLVDKSDSD
10 20 30 40 50 60
MEDPTLYIVE RPLPGYPDAE APEPSSAGAQ AAEEPSGAGS EELIKSDQVN GVLVLSLLDK
70 80 90 100 110 120
IIGAVDQIQL TQAQLEERQA EMEGAVQSIQ GELSKLGKAH ATTSNTVSKL LEKVRKVSVN
130 140 150 160 170 180
VKTVRGSLER QAGQIKKLEV NEAELLRRRN FKVMIYQDEV KLPAKLSISK SLKESEALPE
190 200 210 220 230 240
KEGEELGEGE RPEEDAAALE LSSDEAVEVE EVIEESRAER IKRSGLRRVD DFKKAFSKEK
250 260 270 280 290 300
MEKTKVRTRE NLEKTRLKTK ENLEKTRHTL EKRMNKLGTR LVPAERREKL KTSRDKLRKS
310 320 330 340 350 360
FTPDHVVYAR SKTAVYKVPP FTFHVKKIRE GQVEVLKATE MVEVGADDDE GGAERGEAGD
370 380 390
LRRGSSPDVH ALLEITEESD AVLVDKSDSD
10 20 30 40 50 60
MEDPTLYIVE RPLPGYPDAE APEPSSAGAQ AAEEPSGAGS EELIKSDQVN GVLVLSLLDK
70 80 90 100 110 120
IIGAVDQIQL TQAQLEERQA EMEGAVQSIQ GELSKLGKAH ATTSNTVSKL LEKVRKVSVN
130 140 150 160 170 180
VKTVRGSLER QAGQIKKLEV NEAELLRRRN FKVMIYQDEV KLPAKLSISK SLKESEALPE
190 200 210 220 230 240
KEGEELGEGE RPEEDAAALE LSSDEAVEVE EVIEESRAER IKRSGLRRVD DFKKAFSKEK
250 260 270 280 290 300
MEKTKVRTRE NLEKTRLKTK ENLEKTRHTL EKRMNKLGTR LVPAERREKL KTSRDKLRKS
310 320 330 340 350 360
FTPDHVVYAR SKTAVYKVPP FTFHVKKIRE GQVEVLKATE MVEVGADDDE GGAERGEAGD
370 380 390
LRRGSSPDVH ALLEITEESD AVLVDKSDSD
Protein Neighborhood
Domains & Features
4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q6NZI2-1-unknown | MEDPTL... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86628 | |||
Q6NZI2-1-Acetylation | MEDPTL... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q6NZI2-1-Acetylation | MEDPTL... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q6NZI2-1-Acetylation | MEDPTL... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt109882 | ||
Q6NZI2-205-unknown | EAVEVE... | 205 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12586 | |||
Q6NZI2-205-unknown | EAVEVE... | 205 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt136400 | |||
Q6NZI2-205-unknown | EAVEVE... | 205 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143225 | |||
Q6NZI2-258-unknown | KTKENL... | 258 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14608 | |||
Q6NZI2-258-unknown | KTKENL... | 258 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140336 | |||
Q6NZI2-258-unknown | KTKENL... | 258 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145438 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...ELSSDE | 204 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12586 | |||
...EKTRLK | 257 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14608 | |||
...EKTRLK | 257 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123458 | |||
...EKTRLK | 257 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128731 | |||
...KSDSD | 390 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...KSDSD | 390 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82247 | |||
...KSDSD | 390 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82246 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 204 | SSDE.|.EAVE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAM_HUMAN | 257 | TRLK.|.KTKE | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|