Q6NZJ6: Eukaryotic translation initiation factor 4 gamma 1
Protein names | - Eukaryotic translation initiation factor 4 gamma 1 - eIF-4-gamma 1 - eIF-4G 1 - eIF-4G1 |
---|---|
Gene names | Eif4g1 |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q6NZJ6 |
4
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MNKAPQPTGP PPARSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG GFRSLQHFYP
70 80 90 100 110 120
SRAQPPSSAA SRVQSAAPAR PGPAPHVYPA GSQVMMIPSQ ISYSASQGAY YIPGQGRSTY
130 140 150 160 170 180
VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG AYYPAQGVQQ FPASVAPAPV LMNQPPQIAP
190 200 210 220 230 240
KRERKTIRIR DPNQGGKDIT EEIMSGARTA STPTPPQTGG SLEPQPNGES PQVAVIIRPD
250 260 270 280 290 300
DRSQGAAIGG RPGLPGPEHS PGTESQPSSP SPTPSPPPIL EPGSESNLGV LSIPGDTMTT
310 320 330 340 350 360
GMIPMSVEES TPISCETGEP YCLSPEPTLA EPILEVEVTL SKPIPESEFS SSPLQVSTAL
370 380 390 400 410 420
VPHKVETHEP NGVIPSEDLE PEVESSTEPA PPPLSPCASE SLVPIAPTAQ PEELLNGAPS
430 440 450 460 470 480
PPAVDLSPVS EPEEQAKKVS SAALASILSP APPVAPSDTS PAQEEEMEED DDDEEGGEAE
490 500 510 520 530 540
SEKGGEDVPL DSTPVPAQLS QNLEVAAATQ VAVSVPKRRR KIKELNKKEA VGDLLDAFKE
550 560 570 580 590 600
VDPAVPEVEN QPPTGSNPSP ESEGSMVPTQ PEETEETWDS KEDKIHNAEN IQPGEQKYEY
610 620 630 640 650 660
KSDQWKPLNL EEKKRYDREF LLGFQFIFAS MQKPEGLPHI TDVVLDKANK TPLRQLDPSR
670 680 690 700 710 720
LPGINCGPDF TPSFANLGRP ALSNRGPPRG GPGGELPRGP AGLGPRRSQQ GPRKETRKII
730 740 750 760 770 780
SSVIMTEDIK LNKAEKAWKP SSKRTAADKD RGEEDADGSK TQDLFRRVRS ILNKLTPQMF
790 800 810 820 830 840
QQLMKQVTQL AIDTEERLKG VIDLIFEKAI SEPNFSVAYA NMCRCLMALK VPTTEKPTVT
850 860 870 880 890 900
VNFRKLLLNR CQKEFEKDKD DDEVFEKKQK EMDEAATAEE RGRLKEELEE ARDIARRRSL
910 920 930 940 950 960
GNIKFIGELF KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFAKAKPRMD
970 980 990 1000 1010 1020
QYFNQMEKII KEKKTSSRIR FMLQDVLDLR QSNWVPRRGD QGPKTIDQIH KEAEMEEHRE
1030 1040 1050 1060 1070 1080
HIKVQQLMAK GSDKRRGGPP GPPINRGLPL VDDGGWNTVP ISKGSRPIDT SRLTKITKPG
1090 1100 1110 1120 1130 1140
SIDSNNQLFA PGGRLSWGKG SSGGSGAKPS DTASEATRPA TLNRFSALQQ TLPAENTDNR
1150 1160 1170 1180 1190 1200
RVVQRSSLSR ERGEKAGDRG DRLERSERGG DRGDRLDRAR TPATKRSFSK EVEERSRERP
1210 1220 1230 1240 1250 1260
SQPEGLRKAA SLTEDRGRDP VKREATLPPV SPPKAALSVD EVEKKSKAII EEYLHLNDMK
1270 1280 1290 1300 1310 1320
EAVQCVQELA SPSLLFIFVR LGIESTLERS TIAREHMGRL LHQLLCAGHL STAQYYQGLY
1330 1340 1350 1360 1370 1380
ETLELAEDME IDIPHVWLYL AELITPILQE DGVPMGELFR EITKPLRPMG KATSLLLEIL
1390 1400 1410 1420 1430 1440
GLLCKSMGPK KVGMLWREAG LSWREFLAEG QDVGSFVAEK KVEYTLGEES EAPGQRTLAF
1450 1460 1470 1480 1490 1500
EELRRQLEKL LKDGGSNQRV FDWIDANLNE QQIASNTLVR ALMTTVCYSA IIFETPLRVD
1510 1520 1530 1540 1550 1560
VQVLKVRARL LQKYLCDEQK ELQALYALQA LVVTLEQPAN LLRMFFDALY DEDVVKEDAF
1570 1580 1590 1600
YSWESSKDPA EQQGKGVALK SVTAFFNWLR EAEDEESDHN
Isoforms
- Isoform 2 of Eukaryotic translation initiation factor 4 gamma 1Sequence View
10 20 30 40 50 60
MNKAPQPTGP PPARSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG GFRSLQHFYP
70 80 90 100 110 120
SRAQPPSSAA SRVQSAAPAR PGPAPHVYPA GSQVMMIPSQ ISYSASQGAY YIPGQGRSTY
130 140 150 160 170 180
VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG AYYPAQGVQQ FPASVAPAPV LMNQPPQIAP
190 200 210 220 230 240
KRERKTIRIR DPNQGGKDIT EEIMSGARTA STPTPPQTGG SLEPQPNGES PQVAVIIRPD
250 260 270 280 290 300
DRSQGAAIGG RPGLPGPEHS PGTESQPSSP SPTPSPPPIL EPGSESNLGV LSIPGDTMTT
310 320 330 340 350 360
GMIPMSVEES TPISCETGEP YCLSPEPTLA EPILEVEVTL SKPIPESEFS SSPLQVSTAL
370 380 390 400 410 420
VPHKVETHEP NGVIPSEDLE PEVESSTEPA PPPLSPCASE SLVPIAPTAQ PEELLNGAPS
430 440 450 460 470 480
PPAVDLSPVS EPEEQAKKVS SAALASILSP APPVAPSDTS PAQEEEMEED DDDEEGGEAE
490 500 510 520 530 540
SEKGGEDVPL DSTPVPAQLS QNLEVAAATQ VAVSVPKRRR KIKELNKKEA VGDLLDAFKE
550 560 570 580 590 600
VDPAVPEVEN QPPTGSNPSP ESEGSMVPTQ PEETEETWDS KEDKIHNAEN IQPGEQKYEY
610 620 630 640 650 660
KSDQWKPLNL EEKKRYDREF LLGFQFIFAS MQKPEGLPHI TDVVLDKANK TPLRQLDPSR
670 680 690 700 710 720
LPGINCGPDF TPSFANLGRP ALSNRGPPRG GPGGELPRGP AGLGPRRSQQ GPRKETRKII
730 740 750 760 770 780
SSVIMTEDIK LNKAEKAWKP SSKRTAADKD RGEEDADGSK TQDLFRRVRS ILNKLTPQMF
790 800 810 820 830 840
QQLMKQVTQL AIDTEERLKG VIDLIFEKAI SEPNFSVAYA NMCRCLMALK VPTTEKPTVT
850 860 870 880 890 900
VNFRKLLLNR CQKEFEKDKD DDEVFEKKQK EMDEAATAEE RGRLKEELEE ARDIARRRSL
910 920 930 940 950 960
GNIKFIGELF KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFAKAKPRMD
970 980 990 1000 1010 1020
QYFNQMEKII KEKKTSSRIR FMLQDVLDLR QSNWVPRRGD QGPKTIDQIH KEAEMEEHRE
1030 1040 1050 1060 1070 1080
HIKVQQLMAK GSDKRRGGPP GPPINRGLPL VDDGGWNTVP ISKGSRPIDT SRLTKITKPG
1090 1100 1110 1120 1130 1140
SIDSNNQLFA PGGRLSWGKG SSGGSGAKPS DTASEATRPA TLNRFSALQQ TLPAENTDNR
1150 1160 1170 1180 1190 1200
RVVQRSSLSR ERGEKAGDRG DRLERSERGG DRGDRLDRAR TPATKRSFSK EVEERSRERP
1210 1220 1230 1240 1250 1260
SQPEGLRKAA SLTEDRGRDP VKREATLPPV SPPKAALSVD EVEKKSKAII EEYLHLNDMK
1270 1280 1290 1300 1310 1320
EAVQCVQELA SPSLLFIFVR LGIESTLERS TIAREHMGRL LHQLLCAGHL STAQYYQGLY
1330 1340 1350 1360 1370 1380
ETLELAEDME IDIPHVWLYL AELITPILQE DGVPMGELFR EITKPLRPMG KATSLLLEIL
1390 1400 1410 1420 1430 1440
GLLCKSMGPK KVGMLWREAG LSWREFLAEG QDVGSFVAEK KVEYTLGEES EAPGQRTLAF
1450 1460 1470 1480 1490 1500
EELRRQLEKL LKDGGSNQRV FDWIDANLNE QQIASNTLVR ALMTTVCYSA IIFETPLRVD
1510 1520 1530 1540 1550 1560
VQVLKVRARL LQKYLCDEQK ELQALYALQA LVVTLEQPAN LLRMFFDALY DEDVVKEDAF
1570 1580 1590 1600
YSWESSKDPA EQQGKGVALK SVTAFFNWLR EAEDEESDHN
Protein Neighborhood
Domains & Features
4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q6NZJ6-1-unknown | MNKAPQ... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q6NZJ6-1-unknown | MNKAPQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt77557 | |||
Q6NZJ6-173-unknown | NQPPQI... | 173 | N-TAILS | Overall CM. | auf dem Keller U.: A statistics-based platform for quantitative N-terminome... | 20305283 | |||
Q6NZJ6-173-unknown | NQPPQI... | 173 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160597 | |||
Q6NZJ6-643-unknown | VVLDKA... | 643 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30611 | |||
Q6NZJ6-643-unknown | VVLDKA... | 643 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155163 | |||
Q6NZJ6-670-unknown | FTPSFA... | 670 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32474 | |||
Q6NZJ6-670-unknown | FTPSFA... | 670 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155454 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...PHITDV | 642 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30611 | |||
...PHITDV | 642 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138593 | |||
...NCGPDF | 669 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32474 | |||
...NCGPDF | 669 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138888 | |||
...ESDHN | 1600 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...ESDHN | 1600 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73175 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATE_MOUSE | 642 | ITDV.|.VVLD | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> IF4G1_MOUSE @642 | ||
GRAB_MOUSE | 669 | GPDF.|.FTPS | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|