Q6P1J9: Parafibromin

General Information

Protein names	- Parafibromin - Cell division cycle protein 73 homolog - Hyperparathyroidism 2 protein
Gene names	CDC73
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6P1J9

11 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADVLSVLRQ YNIQKKEIVV KGDEVIFGEF SWPKNVKTNY VVWGTGKEGQ PREYYTLDSI
        70         80         90        100        110        120
LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLGYLNG EASTSASIDR SAPLEIGLQR
       130        140        150        160        170        180
STQVKRAADE VLAEAKKPRI EDEECVRLDK ERLAARLEGH KEGIVQTEQI RSLSEAMSVE
       190        200        210        220        230        240
KIAAIKAKIM AKKRSTIKTD LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS
       250        260        270        280        290        300
TGKNFSKNIF AILQSVKARE EGRAPEQRPA PNAAPVDPTL RTKQPIPAAY NRYDQERFKG
       310        320        330        340        350        360
KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP PNQKKGSRTP
       370        380        390        400        410        420
IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE NETLIQRRKD QMQPGGTAIS
       430        440        450        460        470        480
VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY
       490        500        510        520        530
DEVRLDPNVQ KWDVTVLELS YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F

Isoforms

Sequence View

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Directness:

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

11 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6P1J9-2-unknown	MADVLS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6P1J9-2-Acetylation	ADVLSV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6P1J9-2-Acetylation	ADVLSV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q6P1J9-2-Acetylation	ADVLSV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q6P1J9-2-Acetylation	ADVLSV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q6P1J9-127-	AADEVL...	127			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6P1J9-159-	GHKEGI...	159			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q6P1J9-195-	STIKTD...	195			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6P1J9-195-	STIKTD...	195			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q6P1J9-201-unknown	LDDDIT...	201		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12591
Q6P1J9-212-	SFVDAE...	212			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6P1J9-273-	AAPVDP...	273			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q6P1J9-273-unknown	AAPVDP...	273		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12592
Q6P1J9-322-unknown	SVTEGA...	322			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q6P1J9-322-	SVTEGA...	322			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q6P1J9-322-	SVTEGA...	322			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6P1J9-322-	SVTEGA...	322			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TIKTDL	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12591
...RPAPNA	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12592
...SHLRF	531	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	200	KTDL.\|.LDDD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	272	APNA.\|.AAPV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)