Q6PD62: RNA polymerase-associated protein CTR9 homolog

General Information

Protein names	- RNA polymerase-associated protein CTR9 homolog - SH2 domain-binding protein 1
Gene names	CTR9
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6PD62

8 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRGSIEIPL RDTDEVIELD FDQLPEGDEV ISILKQEHTQ LHIWIALALE YYKQGKTEEF
        70         80         90        100        110        120
VKLLEAARID GNLDYRDHEK DQMTCLDTLA AYYVQQARKE KNKDNKKDLI TQATLLYTMA
       130        140        150        160        170        180
DKIIMYDQNH LLGRACFCLL EGDKMDQADA QFHFVLNQSP NNIPALLGKA CISFNKKDYR
       190        200        210        220        230        240
GALAYYKKAL RTNPGCPAEV RLGMGHCFVK LNKLEKARLA FSRALELNSK CVGALVGLAV
       250        260        270        280        290        300
LELNNKEADS IKNGVQLLSR AYTIDPSNPM VLNHLANHFF FKKDYSKVQH LALHAFHNTE
       310        320        330        340        350        360
VEAMQAESCY QLARSFHVQE DYDQAFQYYY QATQFASSSF VLPFFGLGQM YIYRGDKENA
       370        380        390        400        410        420
SQCFEKVLKA YPNNYETMKI LGSLYAASED QEKRDIAKGH LKKVTEQYPD DVEAWIELAQ
       430        440        450        460        470        480
ILEQTDIQGA LSAYGTATRI LQEKVQADVP PEILNNVGAL HFRLGNLGEA KKYFLASLDR
       490        500        510        520        530        540
AKAEAEHDEH YYNAISVTTS YNLARLYEAM CEFHEAEKLY KNILREHPNY VDCYLRLGAM
       550        560        570        580        590        600
ARDKGNFYEA SDWFKEALQI NQDHPDAWSL IGNLHLAKQE WGPGQKKFER ILKQPSTQSD
       610        620        630        640        650        660
TYSMLALGNV WLQTLHQPTR DREKEKRHQD RALAIYKQVL RNDAKNLYAA NGIGAVLAHK
       670        680        690        700        710        720
GYFREARDVF AQVREATADI SDVWLNLAHI YVEQKQYISA VQMYENCLRK FYKHQNTEVV
       730        740        750        760        770        780
LYLARALFKC GKLQECKQTL LKARHVAPSD TVLMFNVALV LQRLATSVLK DEKSNLKEVL
       790        800        810        820        830        840
NAVKELELAH RYFSYLSKVG DKMRFDLALA ATEARQCSDL LSQAQYHVAR ARKQDEEERE
       850        860        870        880        890        900
LRAKQEQEKE LLRQKLLKEQ EEKRLREKEE QKKLLEQRAQ YVEKTKNILM FTGETEATKE
       910        920        930        940        950        960
KKRGGGGGRR SKKGGEFDEF VNDDTDDDLP ISKKKKRRKG SGSEQEGEDE EGGERKKKKR
       970        980        990       1000       1010       1020
RRHPKGEEGS DDDETENGPK PKKRRPPKAE KKKAPKPERL PPSMKGKIKS KAIISSSDDS
      1030       1040       1050       1060       1070       1080
SDEDKLKIAD EGHPRNSNSN SDSDEDEQRK KCASSESDSD ENQNKSGSEA GSPRRPRRQR
      1090       1100       1110       1120       1130       1140
SDQDSDSDQP SRKRRPSGSE QSDNESVQSG RSHSGVSEND SRPASPSAES DHESERGSDN
      1150       1160       1170
EGSGQGSGNE SEPEGSNNEA SDRGSEHGSD DSD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6PD62-1-unknown	MSRGSI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6PD62-14-unknown	DEVIEL...	14	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431458
Q6PD62-890-unknown	MFTGET...	890	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14620
Q6PD62-895-unknown	TEATKE...	895	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12599
Q6PD62-1012-unknown	AIISSS...	1012		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q6PD62-1012-	AIISSS...	1012		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q6PD62-1012-	AIISSS...	1012		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q6PD62-1012-	AIISSS...	1012		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q6PD62-1121-	SRPASP...	1121		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q6PD62-1121-unknown	SRPASP...	1121		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FGLGQM	349	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431458
...TKNILM	889	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14620
...MFTGET	894	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12599
...SDDSD	1173	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	889	NILM.\|.MFTG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	894	TGET.\|.TEAT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)