Q6WKZ4: Rab11 family-interacting protein 1

General Information

Protein names	- Rab11 family-interacting protein 1 - Rab11-FIP1 - Rab-coupling protein
Gene names	RAB11FIP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6WKZ4

6 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Rab11 family-interacting protein 1 - Isoform 3 of Rab11 family-interacting protein 1 - Isoform 4 of Rab11 family-interacting protein 1 - Isoform 5 of Rab11 family-interacting protein 1

Sequence View

        10         20         30         40         50         60
MSLMVSAGRG LGAVWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE KYATSVSERS
        70         80         90        100        110        120
LGAPVWREEA TFELPSLLSS GPAAAATLQL TVLHRALLGL DKFLGRAEVD LRDLHRDQGR
       130        140        150        160        170        180
RKTQWYKLKS KPGKKDKERG EIEVDIQFMR NNMTASMFDL SMKDKSRNPF GKLKDKIKGK
       190        200        210        220        230        240
NKDSGSDTAS AIIPSTTPSV DSDDESVVKD KKKKSKIKTL LSKSNLQKTP LSQSMSVLPT
       250        260        270        280        290        300
SKPEKVLLRP GDFQSQWDED DNEDESSSAS DVMSHKRTAS TDLKQLNQVN FTLPKKEGLS
       310        320        330        340        350        360
FLGGLRSKND VLSRSNVCIN GNHVYLEQPE AKGEIKDSSP SSSPSPKGFR KKHLFSSTEN
       370        380        390        400        410        420
LAAGSWKEPA EGGGLSSDRQ LSESSTKDSL KSMTLPSYRP APLVSGDLRE NMAPANSEAT
       430        440        450        460        470        480
KEAKESKKPE SRRSSLLSLM TGKKDVAKGS EGENPLTVPG REKEGMLMGV KPGEDASGPA
       490        500        510        520        530        540
EDLVRRSEKD TAAVVSRQGS SLNLFEDVQI TEPEAEPESK SEPRPPISSP RAPQTRAVKP
       550        560        570        580        590        600
RLEVSPEAQP TARLPSPTDS PSSLPPLPSS SGQASVPSEL GHGADTQSSE SPSVFSSLSS
       610        620        630        640        650        660
PIAAPISTST PIESWPLVDR GQAKSEGPPL LPKAELQTES LTPVPNSGSS ALGSLFKQPS
       670        680        690        700        710        720
FPANKGTEDS LMGRTRETGT EKNTSSLELE ESLPEQPETG RQEEELPRFP CKKQDYSPSS
       730        740        750        760        770        780
GEAQEVPFAL SLSSDGAVSP VGELAAGGDR DLESQAGSLV ESKARDAAEE VAPPLPMGAS
       790        800        810        820        830        840
VPSIDSMMRK LEEMGLNLRK DQKKTKKRVS FSEQLFTEEA VAGAALLVEG HSSCPQELNP
       850        860        870        880        890        900
AWSVAGNASD GEPPESPHAE DSERESVTTP GPATCGAPAS PADHLLLPSQ EESFSEVPMS
       910        920        930        940        950        960
EASSAKDTPL FRMEGEDALV TQYQSKASDH EGLLSDPLSD LQLVSDFKSP IMADLNLSLP
       970        980        990       1000       1010       1020
SIPEVASDDE RIDQVEDDGD QVEDDGETAK SSTLDIGALS LGLVVPCPER GKGPSGEADR
      1030       1040       1050       1060       1070       1080
LVLGEGLCDF RLQAPQASVT APSEQTTEFG IHKPHLGKSS SLDKQLPGPS GGEEEKPMGN
      1090       1100       1110       1120       1130       1140
GSPSPPPGTS LDNPVPSPSP SEIFPVTHSF PSSAHSDTHH TSTAESQKKA TAEGSAGRVE
      1150       1160       1170       1180       1190       1200
NFGKRKPLLQ AWVSPSETHP VSAQPGAGTG SAKHRLHPVK PMNAMATKVA NCSLGTATII
      1210       1220       1230       1240       1250       1260
SENLNNEVMM KKYSPSDPAF AYAQLTHDEL IQLVLKQKET ISKKEFQVRE LEDYIDNLLV
      1270       1280
RVMEETPNIL RIPTQVGKKA GKM         10         20         30         40         50         60
MSLMVSAGRG LGAVWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE KYATSVSERS
        70         80         90        100        110        120
LGAPVWREEA TFELPSLLSS GPAAAATLQL TVLHRALLGL DKFLGRAEVD LRDLHRDQGR
       130        140        150        160        170        180
RKTQWYKLKS KPGKKDKERG EIEVDIQFMR NNMTASMFDL SMKDKSRNPF GKLKDKIKGK
       190        200        210        220        230        240
NKDSGSDTAS AIIPSTTPSV DSDDESVVKD KKKKSKIKTL LSKSNLQKTP LSQSMSVLPT
       250        260        270        280        290        300
SKPEKVLLRP GDFQSQWDED DNEDESSSAS DVMSHKRTAS TDLKQLNQVN FTLPKKEGLS
       310        320        330        340        350        360
FLGGLRSKND VLSRSNVCIN GNHVYLEQPE AKGEIKDSSP SSSPSPKGFR KKHLFSSTEN
       370        380        390        400        410        420
LAAGSWKEPA EGGGLSSDRQ LSESSTKDSL KSMTLPSYRP APLVSGDLRE NMAPANSEAT
       430        440        450        460        470        480
KEAKESKKPE SRRSSLLSLM TGKKDVAKGS EGENPLTVPG REKEGMLMGV KPGEDASGPA
       490        500        510        520        530        540
EDLVRRSEKD TAAVVSRQGS SLNLFEDVQI TEPEAEPESK SEPRPPISSP RAPQTRAVKP
       550        560        570        580        590        600
RLEVSPEAQP TARLPSPTDS PSSLPPLPSS SGQASVPSEL GHGADTQSSE SPSVFSSLSS
       610        620        630        640        650        660
PIAAPISTST PIESWPLVDR GQAKSEGPPL LPKAELQTES LTPVPNSGSS ALGSLFKQPS
       670        680        690        700        710        720
FPANKGTEDS LMGRTRETGT EKNTSSLELE ESLPEQPETG RQEEELPRFP CKKQDYSPSS
       730        740        750        760        770        780
GEAQEVPFAL SLSSDGAVSP VGELAAGGDR DLESQAGSLV ESKARDAAEE VAPPLPMGAS
       790        800        810        820        830        840
VPSIDSMMRK LEEMGLNLRK DQKKTKKRVS FSEQLFTEEA VAGAALLVEG HSSCPQELNP
       850        860        870        880        890        900
AWSVAGNASD GEPPESPHAE DSERESVTTP GPATCGAPAS PADHLLLPSQ EESFSEVPMS
       910        920        930        940        950        960
EASSAKDTPL FRMEGEDALV TQYQSKASDH EGLLSDPLSD LQLVSDFKSP IMADLNLSLP
       970        980        990       1000       1010       1020
SIPEVASDDE RIDQVEDDGD QVEDDGETAK SSTLDIGALS LGLVVPCPER GKGPSGEADR
      1030       1040       1050       1060       1070       1080
LVLGEGLCDF RLQAPQASVT APSEQTTEFG IHKPHLGKSS SLDKQLPGPS GGEEEKPMGN
      1090       1100       1110       1120       1130       1140
GSPSPPPGTS LDNPVPSPSP SEIFPVTHSF PSSAHSDTHH TSTAESQKKA TAEGSAGRVE
      1150       1160       1170       1180       1190       1200
NFGKRKPLLQ AWVSPSETHP VSAQPGAGTG SAKHRLHPVK PMNAMATKVA NCSLGTATII
      1210       1220       1230       1240       1250       1260
SENLNNEVMM KKYSPSDPAF AYAQLTHDEL IQLVLKQKET ISKKEFQVRE LEDYIDNLLV
      1270       1280
RVMEETPNIL RIPTQVGKKA GKM         10         20         30         40         50         60
MSLMVSAGRG LGAVWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE KYATSVSERS
        70         80         90        100        110        120
LGAPVWREEA TFELPSLLSS GPAAAATLQL TVLHRALLGL DKFLGRAEVD LRDLHRDQGR
       130        140        150        160        170        180
RKTQWYKLKS KPGKKDKERG EIEVDIQFMR NNMTASMFDL SMKDKSRNPF GKLKDKIKGK
       190        200        210        220        230        240
NKDSGSDTAS AIIPSTTPSV DSDDESVVKD KKKKSKIKTL LSKSNLQKTP LSQSMSVLPT
       250        260        270        280        290        300
SKPEKVLLRP GDFQSQWDED DNEDESSSAS DVMSHKRTAS TDLKQLNQVN FTLPKKEGLS
       310        320        330        340        350        360
FLGGLRSKND VLSRSNVCIN GNHVYLEQPE AKGEIKDSSP SSSPSPKGFR KKHLFSSTEN
       370        380        390        400        410        420
LAAGSWKEPA EGGGLSSDRQ LSESSTKDSL KSMTLPSYRP APLVSGDLRE NMAPANSEAT
       430        440        450        460        470        480
KEAKESKKPE SRRSSLLSLM TGKKDVAKGS EGENPLTVPG REKEGMLMGV KPGEDASGPA
       490        500        510        520        530        540
EDLVRRSEKD TAAVVSRQGS SLNLFEDVQI TEPEAEPESK SEPRPPISSP RAPQTRAVKP
       550        560        570        580        590        600
RLEVSPEAQP TARLPSPTDS PSSLPPLPSS SGQASVPSEL GHGADTQSSE SPSVFSSLSS
       610        620        630        640        650        660
PIAAPISTST PIESWPLVDR GQAKSEGPPL LPKAELQTES LTPVPNSGSS ALGSLFKQPS
       670        680        690        700        710        720
FPANKGTEDS LMGRTRETGT EKNTSSLELE ESLPEQPETG RQEEELPRFP CKKQDYSPSS
       730        740        750        760        770        780
GEAQEVPFAL SLSSDGAVSP VGELAAGGDR DLESQAGSLV ESKARDAAEE VAPPLPMGAS
       790        800        810        820        830        840
VPSIDSMMRK LEEMGLNLRK DQKKTKKRVS FSEQLFTEEA VAGAALLVEG HSSCPQELNP
       850        860        870        880        890        900
AWSVAGNASD GEPPESPHAE DSERESVTTP GPATCGAPAS PADHLLLPSQ EESFSEVPMS
       910        920        930        940        950        960
EASSAKDTPL FRMEGEDALV TQYQSKASDH EGLLSDPLSD LQLVSDFKSP IMADLNLSLP
       970        980        990       1000       1010       1020
SIPEVASDDE RIDQVEDDGD QVEDDGETAK SSTLDIGALS LGLVVPCPER GKGPSGEADR
      1030       1040       1050       1060       1070       1080
LVLGEGLCDF RLQAPQASVT APSEQTTEFG IHKPHLGKSS SLDKQLPGPS GGEEEKPMGN
      1090       1100       1110       1120       1130       1140
GSPSPPPGTS LDNPVPSPSP SEIFPVTHSF PSSAHSDTHH TSTAESQKKA TAEGSAGRVE
      1150       1160       1170       1180       1190       1200
NFGKRKPLLQ AWVSPSETHP VSAQPGAGTG SAKHRLHPVK PMNAMATKVA NCSLGTATII
      1210       1220       1230       1240       1250       1260
SENLNNEVMM KKYSPSDPAF AYAQLTHDEL IQLVLKQKET ISKKEFQVRE LEDYIDNLLV
      1270       1280
RVMEETPNIL RIPTQVGKKA GKM         10         20         30         40         50         60
MSLMVSAGRG LGAVWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE KYATSVSERS
        70         80         90        100        110        120
LGAPVWREEA TFELPSLLSS GPAAAATLQL TVLHRALLGL DKFLGRAEVD LRDLHRDQGR
       130        140        150        160        170        180
RKTQWYKLKS KPGKKDKERG EIEVDIQFMR NNMTASMFDL SMKDKSRNPF GKLKDKIKGK
       190        200        210        220        230        240
NKDSGSDTAS AIIPSTTPSV DSDDESVVKD KKKKSKIKTL LSKSNLQKTP LSQSMSVLPT
       250        260        270        280        290        300
SKPEKVLLRP GDFQSQWDED DNEDESSSAS DVMSHKRTAS TDLKQLNQVN FTLPKKEGLS
       310        320        330        340        350        360
FLGGLRSKND VLSRSNVCIN GNHVYLEQPE AKGEIKDSSP SSSPSPKGFR KKHLFSSTEN
       370        380        390        400        410        420
LAAGSWKEPA EGGGLSSDRQ LSESSTKDSL KSMTLPSYRP APLVSGDLRE NMAPANSEAT
       430        440        450        460        470        480
KEAKESKKPE SRRSSLLSLM TGKKDVAKGS EGENPLTVPG REKEGMLMGV KPGEDASGPA
       490        500        510        520        530        540
EDLVRRSEKD TAAVVSRQGS SLNLFEDVQI TEPEAEPESK SEPRPPISSP RAPQTRAVKP
       550        560        570        580        590        600
RLEVSPEAQP TARLPSPTDS PSSLPPLPSS SGQASVPSEL GHGADTQSSE SPSVFSSLSS
       610        620        630        640        650        660
PIAAPISTST PIESWPLVDR GQAKSEGPPL LPKAELQTES LTPVPNSGSS ALGSLFKQPS
       670        680        690        700        710        720
FPANKGTEDS LMGRTRETGT EKNTSSLELE ESLPEQPETG RQEEELPRFP CKKQDYSPSS
       730        740        750        760        770        780
GEAQEVPFAL SLSSDGAVSP VGELAAGGDR DLESQAGSLV ESKARDAAEE VAPPLPMGAS
       790        800        810        820        830        840
VPSIDSMMRK LEEMGLNLRK DQKKTKKRVS FSEQLFTEEA VAGAALLVEG HSSCPQELNP
       850        860        870        880        890        900
AWSVAGNASD GEPPESPHAE DSERESVTTP GPATCGAPAS PADHLLLPSQ EESFSEVPMS
       910        920        930        940        950        960
EASSAKDTPL FRMEGEDALV TQYQSKASDH EGLLSDPLSD LQLVSDFKSP IMADLNLSLP
       970        980        990       1000       1010       1020
SIPEVASDDE RIDQVEDDGD QVEDDGETAK SSTLDIGALS LGLVVPCPER GKGPSGEADR
      1030       1040       1050       1060       1070       1080
LVLGEGLCDF RLQAPQASVT APSEQTTEFG IHKPHLGKSS SLDKQLPGPS GGEEEKPMGN
      1090       1100       1110       1120       1130       1140
GSPSPPPGTS LDNPVPSPSP SEIFPVTHSF PSSAHSDTHH TSTAESQKKA TAEGSAGRVE
      1150       1160       1170       1180       1190       1200
NFGKRKPLLQ AWVSPSETHP VSAQPGAGTG SAKHRLHPVK PMNAMATKVA NCSLGTATII
      1210       1220       1230       1240       1250       1260
SENLNNEVMM KKYSPSDPAF AYAQLTHDEL IQLVLKQKET ISKKEFQVRE LEDYIDNLLV
      1270       1280
RVMEETPNIL RIPTQVGKKA GKM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6WKZ4-1-unknown	MSLMVS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6WKZ4-1-unknown	MSLMVS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87340
Q6WKZ4-1-unknown	MSLMVS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87343
Q6WKZ4-2-acetylation	SLMVSA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q6WKZ4-2-acetylation	SLMVSA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162910
Q6WKZ4-2-acetylation	SLMVSA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162911
Q6WKZ4-149-unknown	MRNNMT...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87342
Q6WKZ4-149-unknown	MRNNMT...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98454
Q6WKZ4-296-unknown	KEGLSF...	296			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q6WKZ4-296-unknown	KEGLSF...	296		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160107
Q6WKZ4-296-unknown	KEGLSF...	296		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160108
Q6WKZ4-476-unknown	ASGPAE...	476		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12634
Q6WKZ4-476-unknown	ASGPAE...	476		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150480
Q6WKZ4-476-unknown	ASGPAE...	476		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153146
Q6WKZ4-736-	GAVSPV...	736			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q6WKZ4-736-	GAVSPV...	736			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KPGEDA	475	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12634
...KPGEDA	475	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133875
...KPGEDA	475	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136572
...KAGKM	1283	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KAGKM	1283	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82958
...KAGKM	1283		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KAGKM	1283		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KAGKM	1283		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KAGKM	1283		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	475	GEDA.\|.ASGP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)