Q71RC2: La-related protein 4

General Information

Protein names	- La-related protein 4 - La ribonucleoprotein domain family member 4
Gene names	LARP4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q71RC2

12 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of La-related protein 4 - Isoform 3 of La-related protein 4 - Isoform 4 of La-related protein 4 - Isoform 5 of La-related protein 4 - Isoform 6 of La-related protein 4 - Isoform 7 of La-related protein 4

Sequence View

        10         20         30         40         50         60
MLLFVEQVAS KGTGLNPNAK VWQEIAPGNT DATPVTHGTE SSWHEIAATS GAHPEGNAEL
        70         80         90        100        110        120
SEDICKEYEV MYSSSCETTR NTTGIEESTD GMILGPEDLS YQIYDVSGES NSAVSTEDLK
       130        140        150        160        170        180
ECLKKQLEFC FSRENLSKDL YLISQMDSDQ FIPIWTVANM EEIKKLTTDP DLILEVLRSS
       190        200        210        220        230        240
PMVQVDEKGE KVRPSHKRCI VILREIPETT PIEEVKGLFK SENCPKVISC EFAHNSNWYI
       250        260        270        280        290        300
TFQSDTDAQQ AFKYLREEVK TFQGKPIMAR IKAINTFFAK NGYRLMDSSI YSHPIQTQAQ
       310        320        330        340        350        360
YASPVFMQPV YNPHQQYSVY SIVPQSWSPN PTPYFETPLA PFPNGSFVNG FNSPGSYKTN
       370        380        390        400        410        420
AAAMNMGRPF QKNRVKPQFR SSGGSEHSTE GSVSLGDGQL NRYSSRNFPA ERHNPTVTGH
       430        440        450        460        470        480
QEQTYLQKET STLQVEQNGD YGRGRRTLFR GRRRREDDRI SRPHPSTAES KAPTPKFDLL
       490        500        510        520        530        540
ASNFPPLPGS SSRMPGELVL ENRMSDVVKG VYKEKDNEEL TISCPVPADE QTECTSAQQL
       550        560        570        580        590        600
NMSTSSPCAA ELTALSTTQQ EKDLIEDSSV QKDGLNQTTI PVSPPSTTKP SRASTASPCN
       610        620        630        640        650        660
NNINAATAVA LQEPRKLSYA EVCQKPPKEP SSVLVQPLRE LRSNVVSPTK NEDNGAPENS
       670        680        690        700        710        720
VEKPHEKPEA RASKDYSGFR GNIIPRGAAG KIREQRRQFS HRAIPQGVTR RNGKEQYVPP

RSPK         10         20         30         40         50         60
MLLFVEQVAS KGTGLNPNAK VWQEIAPGNT DATPVTHGTE SSWHEIAATS GAHPEGNAEL
        70         80         90        100        110        120
SEDICKEYEV MYSSSCETTR NTTGIEESTD GMILGPEDLS YQIYDVSGES NSAVSTEDLK
       130        140        150        160        170        180
ECLKKQLEFC FSRENLSKDL YLISQMDSDQ FIPIWTVANM EEIKKLTTDP DLILEVLRSS
       190        200        210        220        230        240
PMVQVDEKGE KVRPSHKRCI VILREIPETT PIEEVKGLFK SENCPKVISC EFAHNSNWYI
       250        260        270        280        290        300
TFQSDTDAQQ AFKYLREEVK TFQGKPIMAR IKAINTFFAK NGYRLMDSSI YSHPIQTQAQ
       310        320        330        340        350        360
YASPVFMQPV YNPHQQYSVY SIVPQSWSPN PTPYFETPLA PFPNGSFVNG FNSPGSYKTN
       370        380        390        400        410        420
AAAMNMGRPF QKNRVKPQFR SSGGSEHSTE GSVSLGDGQL NRYSSRNFPA ERHNPTVTGH
       430        440        450        460        470        480
QEQTYLQKET STLQVEQNGD YGRGRRTLFR GRRRREDDRI SRPHPSTAES KAPTPKFDLL
       490        500        510        520        530        540
ASNFPPLPGS SSRMPGELVL ENRMSDVVKG VYKEKDNEEL TISCPVPADE QTECTSAQQL
       550        560        570        580        590        600
NMSTSSPCAA ELTALSTTQQ EKDLIEDSSV QKDGLNQTTI PVSPPSTTKP SRASTASPCN
       610        620        630        640        650        660
NNINAATAVA LQEPRKLSYA EVCQKPPKEP SSVLVQPLRE LRSNVVSPTK NEDNGAPENS
       670        680        690        700        710        720
VEKPHEKPEA RASKDYSGFR GNIIPRGAAG KIREQRRQFS HRAIPQGVTR RNGKEQYVPP

RSPK         10         20         30         40         50         60
MLLFVEQVAS KGTGLNPNAK VWQEIAPGNT DATPVTHGTE SSWHEIAATS GAHPEGNAEL
        70         80         90        100        110        120
SEDICKEYEV MYSSSCETTR NTTGIEESTD GMILGPEDLS YQIYDVSGES NSAVSTEDLK
       130        140        150        160        170        180
ECLKKQLEFC FSRENLSKDL YLISQMDSDQ FIPIWTVANM EEIKKLTTDP DLILEVLRSS
       190        200        210        220        230        240
PMVQVDEKGE KVRPSHKRCI VILREIPETT PIEEVKGLFK SENCPKVISC EFAHNSNWYI
       250        260        270        280        290        300
TFQSDTDAQQ AFKYLREEVK TFQGKPIMAR IKAINTFFAK NGYRLMDSSI YSHPIQTQAQ
       310        320        330        340        350        360
YASPVFMQPV YNPHQQYSVY SIVPQSWSPN PTPYFETPLA PFPNGSFVNG FNSPGSYKTN
       370        380        390        400        410        420
AAAMNMGRPF QKNRVKPQFR SSGGSEHSTE GSVSLGDGQL NRYSSRNFPA ERHNPTVTGH
       430        440        450        460        470        480
QEQTYLQKET STLQVEQNGD YGRGRRTLFR GRRRREDDRI SRPHPSTAES KAPTPKFDLL
       490        500        510        520        530        540
ASNFPPLPGS SSRMPGELVL ENRMSDVVKG VYKEKDNEEL TISCPVPADE QTECTSAQQL
       550        560        570        580        590        600
NMSTSSPCAA ELTALSTTQQ EKDLIEDSSV QKDGLNQTTI PVSPPSTTKP SRASTASPCN
       610        620        630        640        650        660
NNINAATAVA LQEPRKLSYA EVCQKPPKEP SSVLVQPLRE LRSNVVSPTK NEDNGAPENS
       670        680        690        700        710        720
VEKPHEKPEA RASKDYSGFR GNIIPRGAAG KIREQRRQFS HRAIPQGVTR RNGKEQYVPP

RSPK         10         20         30         40         50         60
MLLFVEQVAS KGTGLNPNAK VWQEIAPGNT DATPVTHGTE SSWHEIAATS GAHPEGNAEL
        70         80         90        100        110        120
SEDICKEYEV MYSSSCETTR NTTGIEESTD GMILGPEDLS YQIYDVSGES NSAVSTEDLK
       130        140        150        160        170        180
ECLKKQLEFC FSRENLSKDL YLISQMDSDQ FIPIWTVANM EEIKKLTTDP DLILEVLRSS
       190        200        210        220        230        240
PMVQVDEKGE KVRPSHKRCI VILREIPETT PIEEVKGLFK SENCPKVISC EFAHNSNWYI
       250        260        270        280        290        300
TFQSDTDAQQ AFKYLREEVK TFQGKPIMAR IKAINTFFAK NGYRLMDSSI YSHPIQTQAQ
       310        320        330        340        350        360
YASPVFMQPV YNPHQQYSVY SIVPQSWSPN PTPYFETPLA PFPNGSFVNG FNSPGSYKTN
       370        380        390        400        410        420
AAAMNMGRPF QKNRVKPQFR SSGGSEHSTE GSVSLGDGQL NRYSSRNFPA ERHNPTVTGH
       430        440        450        460        470        480
QEQTYLQKET STLQVEQNGD YGRGRRTLFR GRRRREDDRI SRPHPSTAES KAPTPKFDLL
       490        500        510        520        530        540
ASNFPPLPGS SSRMPGELVL ENRMSDVVKG VYKEKDNEEL TISCPVPADE QTECTSAQQL
       550        560        570        580        590        600
NMSTSSPCAA ELTALSTTQQ EKDLIEDSSV QKDGLNQTTI PVSPPSTTKP SRASTASPCN
       610        620        630        640        650        660
NNINAATAVA LQEPRKLSYA EVCQKPPKEP SSVLVQPLRE LRSNVVSPTK NEDNGAPENS
       670        680        690        700        710        720
VEKPHEKPEA RASKDYSGFR GNIIPRGAAG KIREQRRQFS HRAIPQGVTR RNGKEQYVPP

RSPK         10         20         30         40         50         60
MLLFVEQVAS KGTGLNPNAK VWQEIAPGNT DATPVTHGTE SSWHEIAATS GAHPEGNAEL
        70         80         90        100        110        120
SEDICKEYEV MYSSSCETTR NTTGIEESTD GMILGPEDLS YQIYDVSGES NSAVSTEDLK
       130        140        150        160        170        180
ECLKKQLEFC FSRENLSKDL YLISQMDSDQ FIPIWTVANM EEIKKLTTDP DLILEVLRSS
       190        200        210        220        230        240
PMVQVDEKGE KVRPSHKRCI VILREIPETT PIEEVKGLFK SENCPKVISC EFAHNSNWYI
       250        260        270        280        290        300
TFQSDTDAQQ AFKYLREEVK TFQGKPIMAR IKAINTFFAK NGYRLMDSSI YSHPIQTQAQ
       310        320        330        340        350        360
YASPVFMQPV YNPHQQYSVY SIVPQSWSPN PTPYFETPLA PFPNGSFVNG FNSPGSYKTN
       370        380        390        400        410        420
AAAMNMGRPF QKNRVKPQFR SSGGSEHSTE GSVSLGDGQL NRYSSRNFPA ERHNPTVTGH
       430        440        450        460        470        480
QEQTYLQKET STLQVEQNGD YGRGRRTLFR GRRRREDDRI SRPHPSTAES KAPTPKFDLL
       490        500        510        520        530        540
ASNFPPLPGS SSRMPGELVL ENRMSDVVKG VYKEKDNEEL TISCPVPADE QTECTSAQQL
       550        560        570        580        590        600
NMSTSSPCAA ELTALSTTQQ EKDLIEDSSV QKDGLNQTTI PVSPPSTTKP SRASTASPCN
       610        620        630        640        650        660
NNINAATAVA LQEPRKLSYA EVCQKPPKEP SSVLVQPLRE LRSNVVSPTK NEDNGAPENS
       670        680        690        700        710        720
VEKPHEKPEA RASKDYSGFR GNIIPRGAAG KIREQRRQFS HRAIPQGVTR RNGKEQYVPP

RSPK         10         20         30         40         50         60
MLLFVEQVAS KGTGLNPNAK VWQEIAPGNT DATPVTHGTE SSWHEIAATS GAHPEGNAEL
        70         80         90        100        110        120
SEDICKEYEV MYSSSCETTR NTTGIEESTD GMILGPEDLS YQIYDVSGES NSAVSTEDLK
       130        140        150        160        170        180
ECLKKQLEFC FSRENLSKDL YLISQMDSDQ FIPIWTVANM EEIKKLTTDP DLILEVLRSS
       190        200        210        220        230        240
PMVQVDEKGE KVRPSHKRCI VILREIPETT PIEEVKGLFK SENCPKVISC EFAHNSNWYI
       250        260        270        280        290        300
TFQSDTDAQQ AFKYLREEVK TFQGKPIMAR IKAINTFFAK NGYRLMDSSI YSHPIQTQAQ
       310        320        330        340        350        360
YASPVFMQPV YNPHQQYSVY SIVPQSWSPN PTPYFETPLA PFPNGSFVNG FNSPGSYKTN
       370        380        390        400        410        420
AAAMNMGRPF QKNRVKPQFR SSGGSEHSTE GSVSLGDGQL NRYSSRNFPA ERHNPTVTGH
       430        440        450        460        470        480
QEQTYLQKET STLQVEQNGD YGRGRRTLFR GRRRREDDRI SRPHPSTAES KAPTPKFDLL
       490        500        510        520        530        540
ASNFPPLPGS SSRMPGELVL ENRMSDVVKG VYKEKDNEEL TISCPVPADE QTECTSAQQL
       550        560        570        580        590        600
NMSTSSPCAA ELTALSTTQQ EKDLIEDSSV QKDGLNQTTI PVSPPSTTKP SRASTASPCN
       610        620        630        640        650        660
NNINAATAVA LQEPRKLSYA EVCQKPPKEP SSVLVQPLRE LRSNVVSPTK NEDNGAPENS
       670        680        690        700        710        720
VEKPHEKPEA RASKDYSGFR GNIIPRGAAG KIREQRRQFS HRAIPQGVTR RNGKEQYVPP

RSPK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q71RC2-1-	MLLFVE...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q71RC2-1-	MLLFVE...	1			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q71RC2-1-	MLLFVE...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q71RC2-1-	MLLFVE...	1			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q71RC2-1-	MLLFVE...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q71RC2-1-	MLLFVE...	1			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q71RC2-1-Acetylation	MLLFVE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q71RC2-1-Acetylation	MLLFVE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101045
Q71RC2-1-Acetylation	MLLFVE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101046
Q71RC2-1-Acetylation	MLLFVE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101047
Q71RC2-1-Acetylation	MLLFVE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101048
Q71RC2-1-unknown	MLLFVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79384
Q71RC2-1-unknown	MLLFVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79385
Q71RC2-1-unknown	MLLFVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79386
Q71RC2-1-unknown	MLLFVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79387
Q71RC2-3-unknown	LFVEQV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164855
Q71RC2-3-unknown	LFVEQV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164856
Q71RC2-3-unknown	LFVEQV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164857
Q71RC2-3-unknown	LFVEQV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164858
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q71RC2-3-	LFVEQV...	3			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q71RC2-4-unknown	FVEQVA...	4		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166482
Q71RC2-4-unknown	FVEQVA...	4		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166483
Q71RC2-4-unknown	FVEQVA...	4		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166484
Q71RC2-4-unknown	FVEQVA...	4		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166485
Q71RC2-4-	FVEQVA...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q71RC2-4-	FVEQVA...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q71RC2-4-	FVEQVA...	4			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q71RC2-4-	FVEQVA...	4			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q71RC2-573-unknown	DGLNQT...	573			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q71RC2-573-unknown	DGLNQT...	573		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161753
Q71RC2-573-unknown	DGLNQT...	573		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161754
Q71RC2-573-unknown	DGLNQT...	573		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161756
Q71RC2-573-unknown	DGLNQT...	573		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161755
Q71RC2-574-unknown	GLNQTT...	574		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165189
Q71RC2-574-unknown	GLNQTT...	574		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165190
Q71RC2-574-unknown	GLNQTT...	574		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165192
Q71RC2-574-unknown	GLNQTT...	574		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165191
Q71RC2-574-	GLNQTT...	574			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q71RC2-574-	GLNQTT...	574			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q71RC2-574-	GLNQTT...	574			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q71RC2-574-	GLNQTT...	574			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q71RC2-574-	GLNQTT...	574			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q71RC2-574-	GLNQTT...	574			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q71RC2-574-	GLNQTT...	574			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q71RC2-574-	GLNQTT...	574			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q71RC2-574-	GLNQTT...	574			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q71RC2-660-	SVEKPH...	660			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q71RC2-660-unknown	SVEKPH...	660		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170263
Q71RC2-660-unknown	SVEKPH...	660		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170259
Q71RC2-660-unknown	SVEKPH...	660		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170260
Q71RC2-660-unknown	SVEKPH...	660		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170262
Q71RC2-660-unknown	SVEKPH...	660		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170261

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YGRGRR	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75005
...YGRGRR	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92796
...YGRGRR	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92793
...YGRGRR	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92795
...YGRGRR	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92794
...PRSPK	724	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PRSPK	724	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75000
...PRSPK	724	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75003
...PRSPK	724	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75004
...PRSPK	724	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75001
...PRSPK	724	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75002

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)