Q7KZI7: Serine/threonine-protein kinase MARK2

General Information

Protein names	- Serine/threonine-protein kinase MARK2 - 2.7.11.1 - 2.7.11.26 - ELKL motif kinase 1 - EMK-1 - MAP/microtubule affinity-regulating kinase 2 - PAR1 homolog - PAR1 homolog b - Par-1b - Par1b
Gene names	MARK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7KZI7

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein kinase MARK2 - Isoform 3 of Serine/threonine-protein kinase MARK2 - Isoform 4 of Serine/threonine-protein kinase MARK2 - Isoform 5 of Serine/threonine-protein kinase MARK2 - Isoform 6 of Serine/threonine-protein kinase MARK2 - Isoform 7 of Serine/threonine-protein kinase MARK2 - Isoform 8 of Serine/threonine-protein kinase MARK2 - Isoform 9 of Serine/threonine-protein kinase MARK2 - Isoform 10 of Serine/threonine-protein kinase MARK2 - Isoform 11 of Serine/threonine-protein kinase MARK2 - Isoform 12 of Serine/threonine-protein kinase MARK2 - Isoform 13 of Serine/threonine-protein kinase MARK2 - Isoform 14 of Serine/threonine-protein kinase MARK2 - Isoform 15 of Serine/threonine-protein kinase MARK2 - Isoform 16 of Serine/threonine-protein kinase MARK2

Sequence View

        10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS
       430        440        450        460        470        480
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST
       490        500        510        520        530        540
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP
       550        560        570        580        590        600
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
       610        620        630        640        650        660
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE
       670        680        690        700        710        720
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA
       730        740        750        760        770        780
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS

KIANELKL

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7KZI7-1-unknown	MSSART...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7KZI7-1-unknown	MSSART...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80427
Q7KZI7-1-unknown	MSSART...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80428
Q7KZI7-1-unknown	MSSART...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80431
Q7KZI7-1-unknown	MSSART...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80432
Q7KZI7-34-unknown	MIRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80425
Q7KZI7-34-unknown	MIRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80426
Q7KZI7-34-unknown	MIRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80429
Q7KZI7-34-unknown	MIRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80430
Q7KZI7-34-unknown	MIRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98188
Q7KZI7-34-unknown	MIRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98189
Q7KZI7-34-unknown	MIRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98190
Q7KZI7-34-unknown	MIRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98191
Q7KZI7-474-unknown	SVLSTS...	474	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172806
Q7KZI7-474-unknown	SVLSTS...	474	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172807
Q7KZI7-474-unknown	SVLSTS...	474	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172810
Q7KZI7-474-unknown	SVLSTS...	474	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172811
Q7KZI7-474-unknown	SVLSTS...	474	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172804
Q7KZI7-474-unknown	SVLSTS...	474	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172805
Q7KZI7-474-unknown	SVLSTS...	474	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172808
Q7KZI7-474-unknown	SVLSTS...	474	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172809
Q7KZI7-474-	SVLSTS...	474		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7KZI7-568-unknown	ASPSAH...	568	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14650
Q7KZI7-568-unknown	ASPSAH...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153815
Q7KZI7-568-unknown	ASPSAH...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153816
Q7KZI7-568-unknown	ASPSAH...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154199
Q7KZI7-568-unknown	ASPSAH...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199806
Q7KZI7-568-unknown	ASPSAH...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199809
Q7KZI7-568-unknown	ASPSAH...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199805
Q7KZI7-568-unknown	ASPSAH...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199807
Q7KZI7-568-unknown	ASPSAH...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199808
Q7KZI7-614-	GVTPAS...	614		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q7KZI7-614-unknown	GVTPAS...	614	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169780
Q7KZI7-614-unknown	GVTPAS...	614	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169785
Q7KZI7-614-unknown	GVTPAS...	614	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169778
Q7KZI7-614-unknown	GVTPAS...	614	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169782
Q7KZI7-614-unknown	GVTPAS...	614	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169783
Q7KZI7-614-unknown	GVTPAS...	614	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169781
Q7KZI7-614-unknown	GVTPAS...	614	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169784
Q7KZI7-614-unknown	GVTPAS...	614	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169779

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QRVPVA	567	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14650
...QRVPVA	567	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137237
...QRVPVA	567	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137238
...QRVPVA	567	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137619
...NELKL	788	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NELKL	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76048
...NELKL	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76043
...NELKL	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76046
...NELKL	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76045
...NELKL	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76050
...NELKL	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76044
...NELKL	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76047
...NELKL	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76049

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	567	VPVA.\|.ASPS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)