Q7L2J0: 7SK snRNA methylphosphate capping enzyme

General Information

Protein names	- 7SK snRNA methylphosphate capping enzyme - MePCE - 2.1.1.- - Bicoid-interacting protein 3 homolog - Bin3 homolog
Gene names	MEPCE
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7L2J0

7 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MIEMAAEKEP FLVPAPPPPL KDESGGGGGP TVPPHQEAAS GELRGGTERG PGRCAPSAGS
        70         80         90        100        110        120
PAAAVGRESP GAAATSSSGP QAQQHRGGGP QAQSHGEARL SDPPGRAAPP DVGEERRGGG
       130        140        150        160        170        180
GTELGPPAPP RPRNGYQPHR PPGGGGGKRR NSCNVGGGGG GFKHPAFKRR RRVNSDCDSV
       190        200        210        220        230        240
LPSNFLLGGN IFDPLNLNSL LDEEVSRTLN AETPKSSPLP AKGRDPVEIL IPKDITDPLS
       250        260        270        280        290        300
LNTCTDEGHV VLASPLKTGR KRHRHRGQHH QQQQAAGGSE SHPVPPTAPL TPLLHGEGAS
       310        320        330        340        350        360
QQPRHRGQNR DAPQPYELNT AINCRDEVVS PLPSALQGPS GSLSAPPAAS VISAPPSSSS
       370        380        390        400        410        420
RHRKRRRTSS KSEAGARGGG QGSKEKGRGS WGGRHHHHHP LPAAGFKKQQ RKFQYGNYCK
       430        440        450        460        470        480
YYGYRNPSCE DGRLRVLKPE WFRGRDVLDL GCNVGHLTLS IACKWGPSRM VGLDIDSRLI
       490        500        510        520        530        540
HSARQNIRHY LSEELRLPPQ TLEGDPGAEG EEGTTTVRKR SCFPASLTAS RGPIAAPQVP
       550        560        570        580        590        600
LDGADTSVFP NNVVFVTGNY VLDRDDLVEA QTPEYDVVLC LSLTKWVHLN WGDEGLKRMF
       610        620        630        640        650        660
RRIYRHLRPG GILVLEPQPW SSYGKRKTLT ETIYKNYYRI QLKPEQFSSY LTSPDVGFSS
       670        680
YELVATPHNT SKGFQRPVYL FHKARSPSH

Isoforms

- Isoform 2 of 7SK snRNA methylphosphate capping enzyme

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7L2J0-1-Acetylation	MIEMAA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7L2J0-199-	SLLDEE...	199			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7L2J0-240-unknown	SLNTCT...	240		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14658
Q7L2J0-337-unknown	QGPSGS...	337		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14659
Q7L2J0-470-unknown	MVGLDI...	470		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80897
Q7L2J0-503-unknown	EGDPGA...	503		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14660
Q7L2J0-503-unknown	EGDPGA...	503		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137860
Q7L2J0-542-unknown	DGADTS...	542		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14662
Q7L2J0-542-unknown	DGADTS...	542		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140823

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ITDPLS	239	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14658
...LPSALQ	336	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14659
...PPQTLE	502	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14660
...PPQTLE	502	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120865
...PQVPLD	541	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14662
...PQVPLD	541	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123962
...RSPSH	689	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RSPSH	689	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76515

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	239	DPLS.\|.SLNT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	336	SALQ.\|.QGPS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	502	QTLE.\|.EGDP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	541	VPLD.\|.DGAD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)