Q7Z417: Nuclear fragile X mental retardation-interacting protein 2

General Information

Protein names	- Nuclear fragile X mental retardation-interacting protein 2 - 82 kDa FMRP-interacting protein - 82-FIP - Cell proliferation-inducing gene 1 protein - FMRP-interacting protein 2
Gene names	NUFIP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7Z417

9 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEEKPGQPQP QHHHSHHHPH HHPQQQQQQP HHHHHYYFYN HSHNHHHHHH HQQPHQYLQH
        70         80         90        100        110        120
GAEGSPKAQP KPLKHEQKHT LQQHQETPKK KTGYGELNGN AGEREISLKN LSSDEATNPI
       130        140        150        160        170        180
SRVLNGNQQV VDTSLKQTVK ANTFGKAGIK TKNFIQKNSM DKKNGKSYEN KSGENQSVDK
       190        200        210        220        230        240
SDTIPIPNGV VTNNSGYITN GYMGKGADND GSGSESGYTT PKKRKARRNS AKGCENLNIV
       250        260        270        280        290        300
QDKIMQQETS VPTLKQGLET FKPDYSEQKG NRVDGSKPIW KYETGPGGTS RGKPAVGDML
       310        320        330        340        350        360
RKSSDSKPGV SSKKFDDRPK GKHASAVASK EDSWTLFKPP PVFPVDNSSA KIVPKISYAS
       370        380        390        400        410        420
KVKENLNKTI QNSSVSPTSS SSSSSSTGET QTQSSSRLSQ VPMSALKSVT SANFSNGPVL
       430        440        450        460        470        480
AGTDGNVYPP GGQPLLTTAA NTLTPISSGT DSVLQDMSLT SAAVEQIKTS LFIYPSNMQT
       490        500        510        520        530        540
MLLSTAQVDL PSQTDQQNLG DIFQNQWGLS FINEPSAGPE TVTGKSSEHK VMEVTFQGEY
       550        560        570        580        590        600
PATLVSQGAE IIPSGTEHPV FPKAYELEKR TSPQVLGSIL KSGTTSESGA LSLEPSHIGD
       610        620        630        640        650        660
LQKADTSSQG ALVFLSKDYE IESQNPLASP TNTLLGSAKE QRYQRGLERN DSWGSFDLRA
       670        680        690
AIVYHTKEME SIWNLQKQDP KRIITYNEAM DSPDQ

Isoforms

- Isoform 2 of Nuclear fragile X mental retardation-interacting protein 2

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7Z417-1-unknown	MEEKPG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7Z417-110-unknown	NLSSDE...	110		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q7Z417-110-	NLSSDE...	110		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q7Z417-259-unknown	ETFKPD...	259	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14669
Q7Z417-275-	GSKPIW...	275		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7Z417-292-	GKPAVG...	292		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q7Z417-379-unknown	SSSSSS...	379	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14670
Q7Z417-452-	SVLQDM...	452		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7Z417-452-	SVLQDM...	452		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7Z417-578-	SILKSG...	578		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q7Z417-578-	SILKSG...	578		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LKQGLE	258	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14669
...SVSPTS	378	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14670
...DSPDQ	695		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DSPDQ	695		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DSPDQ	695	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DSPDQ	695		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DSPDQ	695		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	258	QGLE.\|.ETFK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	378	SPTS.\|.SSSS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)