Q7Z4Q2: HEAT repeat-containing protein 3

General Information

Protein names	- HEAT repeat-containing protein 3
Gene names	HEATR3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7Z4Q2

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of HEAT repeat-containing protein 3 - Isoform 3 of HEAT repeat-containing protein 3

Sequence View

        10         20         30         40         50         60
MGKSRTKRFK RPQFSPTGDC QAEAAAAANG TGGEEDDGPA AELLEKLQHP SAEVRECACA
        70         80         90        100        110        120
GLARLVQQRP ALPGLARRDA VRRLGPLLLD PSLAVRETAA GALRNLSACG GFEVCDDMVT
       130        140        150        160        170        180
KDIMTPLVAL LKECSAGLDS NEMSLQEKKD QNRNSIENIA NETVNVLWNI CECSSRAVSI
       190        200        210        220        230        240
FNKEGCLEIV LKYLSRFPTN VDLAISVAYC LQTVTEDNPE LLKSFSATAL NMLESALLSP
       250        260        270        280        290        300
VSSMESLLLK TLVAGTIWNL KDIIPCKSQA EIINALLKIL SEVLGMDAGE MVIQMKEAET
       310        320        330        340        350        360
QRLKTAAEAE EILENTNGDD LIEDDEMEGI SHKRRVRRKT FVSDLLPPTD KELRETIALL
       370        380        390        400        410        420
TAQQTALEII VNMCCNEDPS DDEWEELSSS DESDAFMENS FSECGGQLFS PLCLSHEVHT
       430        440        450        460        470        480
ALTNYLIPKK IFEKTAFPNS IAVDLCSRNP TWKPLIRKMN TIQCRALFCL QSLVSLLDVE
       490        500        510        520        530        540
HLGGAAALQT LAQHLSQLLF SQPDFAKHVD FLEAISSALR ALLQTMASKN ISQCMTPDQL
       550        560        570        580        590        600
MTLCKAGIHS SNVGVRVNVV SILGITGSVL AKEDGTLETL KNIGCFLLEV TTKDPSLVVA
       610        620        630        640        650        660
GEALDALFDV FADGKEAERA SIQIKLLSAL KEFQPVFKMK IRKEGRGNYS TDQLCVLDNV
       670        680
KMNLRRFIAY QETVEKRLTS         10         20         30         40         50         60
MGKSRTKRFK RPQFSPTGDC QAEAAAAANG TGGEEDDGPA AELLEKLQHP SAEVRECACA
        70         80         90        100        110        120
GLARLVQQRP ALPGLARRDA VRRLGPLLLD PSLAVRETAA GALRNLSACG GFEVCDDMVT
       130        140        150        160        170        180
KDIMTPLVAL LKECSAGLDS NEMSLQEKKD QNRNSIENIA NETVNVLWNI CECSSRAVSI
       190        200        210        220        230        240
FNKEGCLEIV LKYLSRFPTN VDLAISVAYC LQTVTEDNPE LLKSFSATAL NMLESALLSP
       250        260        270        280        290        300
VSSMESLLLK TLVAGTIWNL KDIIPCKSQA EIINALLKIL SEVLGMDAGE MVIQMKEAET
       310        320        330        340        350        360
QRLKTAAEAE EILENTNGDD LIEDDEMEGI SHKRRVRRKT FVSDLLPPTD KELRETIALL
       370        380        390        400        410        420
TAQQTALEII VNMCCNEDPS DDEWEELSSS DESDAFMENS FSECGGQLFS PLCLSHEVHT
       430        440        450        460        470        480
ALTNYLIPKK IFEKTAFPNS IAVDLCSRNP TWKPLIRKMN TIQCRALFCL QSLVSLLDVE
       490        500        510        520        530        540
HLGGAAALQT LAQHLSQLLF SQPDFAKHVD FLEAISSALR ALLQTMASKN ISQCMTPDQL
       550        560        570        580        590        600
MTLCKAGIHS SNVGVRVNVV SILGITGSVL AKEDGTLETL KNIGCFLLEV TTKDPSLVVA
       610        620        630        640        650        660
GEALDALFDV FADGKEAERA SIQIKLLSAL KEFQPVFKMK IRKEGRGNYS TDQLCVLDNV
       670        680
KMNLRRFIAY QETVEKRLTS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7Z4Q2-1-unknown	MGKSRT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7Z4Q2-30-	GTGGEE...	30		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7Z4Q2-320-unknown	DLIEDD...	320	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12684
Q7Z4Q2-320-unknown	DLIEDD...	320	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147880
Q7Z4Q2-320-unknown	DLIEDD...	320	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147881

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NTNGDD	319	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12684
...NTNGDD	319	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131239
...NTNGDD	319	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131240
...KRLTS	680	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KRLTS	680	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72478

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	319	NGDD.\|.DLIE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)