Q86TI2: Dipeptidyl peptidase 9

General Information

Protein names	- Dipeptidyl peptidase 9 - DP9 - 3.4.14.5 {ECO:0000269\|PubMed:12662155, ECO:0000269\|PubMed:16475979, ECO:0000269\|PubMed:29382749} - Dipeptidyl peptidase IV-related protein 2 - DPRP-2 - Dipeptidyl peptidase IX - DPP IX - Dipeptidyl peptidase-like protein 9 - DPLP9
Gene names	DPP9
Organism	Homo sapiens
Protease Family	S09.019
Protease ID	S09.019
Chromosome location
UniProt ID	Q86TI2

5 N-termini

1 C-termini

0 Cleavages

2 Substrates

Sequence

Isoforms

- Isoform 2 of Dipeptidyl peptidase 9 - Isoform 3 of Dipeptidyl peptidase 9

Sequence View

        10         20         30         40         50         60
MATTGTPTAD RGDAAATDDP AARFQVQKHS WDGLRSIIHG SRKYSGLIVN KAPHDFQFVQ
        70         80         90        100        110        120
KTDESGPHSH RLYYLGMPYG SRENSLLYSE IPKKVRKEAL LLLSWKQMLD HFQATPHHGV
       130        140        150        160        170        180
YSREEELLRE RKRLGVFGIT SYDFHSESGL FLFQASNSLF HCRDGGKNGF MVSPMKPLEI
       190        200        210        220        230        240
KTQCSGPRMD PKICPADPAF FSFINNSDLW VANIETGEER RLTFCHQGLS NVLDDPKSAG
       250        260        270        280        290        300
VATFVIQEEF DRFTGYWWCP TASWEGSEGL KTLRILYEEV DESEVEVIHV PSPALEERKT
       310        320        330        340        350        360
DSYRYPRTGS KNPKIALKLA EFQTDSQGKI VSTQEKELVQ PFSSLFPKVE YIARAGWTRD
       370        380        390        400        410        420
GKYAWAMFLD RPQQWLQLVL LPPALFIPST ENEEQRLASA RAVPRNVQPY VVYEEVTNVW
       430        440        450        460        470        480
INVHDIFYPF PQSEGEDELC FLRANECKTG FCHLYKVTAV LKSQGYDWSE PFSPGEDEFK
       490        500        510        520        530        540
CPIKEEIALT SGEWEVLARH GSKIWVNEET KLVYFQGTKD TPLEHHLYVV SYEAAGEIVR
       550        560        570        580        590        600
LTTPGFSHSC SMSQNFDMFV SHYSSVSTPP CVHVYKLSGP DDDPLHKQPR FWASMMEAAS
       610        620        630        640        650        660
CPPDYVPPEI FHFHTRSDVR LYGMIYKPHA LQPGKKHPTV LFVYGGPQVQ LVNNSFKGIK
       670        680        690        700        710        720
YLRLNTLASL GYAVVVIDGR GSCQRGLRFE GALKNQMGQV EIEDQVEGLQ FVAEKYGFID
       730        740        750        760        770        780
LSRVAIHGWS YGGFLSLMGL IHKPQVFKVA IAGAPVTVWM AYDTGYTERY MDVPENNQHG
       790        800        810        820        830        840
YEAGSVALHV EKLPNEPNRL LILHGFLDEN VHFFHTNFLV SQLIRAGKPY QLQIYPNERH
       850        860
SIRCPESGEH YEVTLLHFLQ EYL         10         20         30         40         50         60
MATTGTPTAD RGDAAATDDP AARFQVQKHS WDGLRSIIHG SRKYSGLIVN KAPHDFQFVQ
        70         80         90        100        110        120
KTDESGPHSH RLYYLGMPYG SRENSLLYSE IPKKVRKEAL LLLSWKQMLD HFQATPHHGV
       130        140        150        160        170        180
YSREEELLRE RKRLGVFGIT SYDFHSESGL FLFQASNSLF HCRDGGKNGF MVSPMKPLEI
       190        200        210        220        230        240
KTQCSGPRMD PKICPADPAF FSFINNSDLW VANIETGEER RLTFCHQGLS NVLDDPKSAG
       250        260        270        280        290        300
VATFVIQEEF DRFTGYWWCP TASWEGSEGL KTLRILYEEV DESEVEVIHV PSPALEERKT
       310        320        330        340        350        360
DSYRYPRTGS KNPKIALKLA EFQTDSQGKI VSTQEKELVQ PFSSLFPKVE YIARAGWTRD
       370        380        390        400        410        420
GKYAWAMFLD RPQQWLQLVL LPPALFIPST ENEEQRLASA RAVPRNVQPY VVYEEVTNVW
       430        440        450        460        470        480
INVHDIFYPF PQSEGEDELC FLRANECKTG FCHLYKVTAV LKSQGYDWSE PFSPGEDEFK
       490        500        510        520        530        540
CPIKEEIALT SGEWEVLARH GSKIWVNEET KLVYFQGTKD TPLEHHLYVV SYEAAGEIVR
       550        560        570        580        590        600
LTTPGFSHSC SMSQNFDMFV SHYSSVSTPP CVHVYKLSGP DDDPLHKQPR FWASMMEAAS
       610        620        630        640        650        660
CPPDYVPPEI FHFHTRSDVR LYGMIYKPHA LQPGKKHPTV LFVYGGPQVQ LVNNSFKGIK
       670        680        690        700        710        720
YLRLNTLASL GYAVVVIDGR GSCQRGLRFE GALKNQMGQV EIEDQVEGLQ FVAEKYGFID
       730        740        750        760        770        780
LSRVAIHGWS YGGFLSLMGL IHKPQVFKVA IAGAPVTVWM AYDTGYTERY MDVPENNQHG
       790        800        810        820        830        840
YEAGSVALHV EKLPNEPNRL LILHGFLDEN VHFFHTNFLV SQLIRAGKPY QLQIYPNERH
       850        860
SIRCPESGEH YEVTLLHFLQ EYL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86TI2-1-unknown	MATTGT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73216
Q86TI2-1-unknown	MATTGT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95753
Q86TI2-2-unknown	MATTGT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86TI2-2-Acetylation	ATTGTP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86TI2-2-Acetylation	ATTGTP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q86TI2-2-Acetylation	ATTGTP...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q86TI2-2-Acetylation	ATTGTP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110366
Q86TI2-2-Acetylation	ATTGTP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110367
Q86TI2-14-	AAATDD...	14			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q86TI2-14-unknown	AAATDD...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165297
Q86TI2-14-unknown	AAATDD...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165298

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LQEYL	863	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...LQEYL	863	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68833

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
SMBT1_HUMAN	35	AVPY.\|.YGSF	inferred from experiment	unknown	MEROPS	Melchior F	Geiss-Friedlander R et al.:The cytoplasmic peptidase DPP9 ... (S09.019)	19667070,
SMBT1-Isoform2_HUMAN	35	AVPY.\|.YGSF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8512