Q86UK7: E3 ubiquitin-protein ligase ZNF598 {ECO:0000305}

General Information

Protein names	- E3 ubiquitin-protein ligase ZNF598 {ECO:0000305} - 2.3.2.27 {ECO:0000305\|PubMed:28065601, ECO:0000305\|PubMed:28132843} - Zinc finger protein 598 {ECO:0000312\|HGNC:HGNC:28079}
Gene names	ZNF598
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86UK7

8 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Zinc finger protein 598 - Isoform 3 of Zinc finger protein 598 - Isoform 4 of Zinc finger protein 598 - Isoform 2 of E3 ubiquitin-protein ligase ZNF598 - Isoform 3 of E3 ubiquitin-protein ligase ZNF598 - Isoform 4 of E3 ubiquitin-protein ligase ZNF598

Sequence View

        10         20         30         40         50         60
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY RCSTKMRVLC
        70         80         90        100        110        120
EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI YFADGKVYAL YRQLLQHECP
       130        140        150        160        170        180
RCPELPPFSL FGDLEQHMRR QHELFCCRLC LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD
       190        200        210        220        230        240
TSHRGHPLCK FCDERYLDND ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF
       250        260        270        280        290        300
LCEEGRCSTE QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV
       310        320        330        340        350        360
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR ASVAAQQQEE
       370        380        390        400        410        420
ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP GPKETSTNGP VSQEAFSVTG
       430        440        450        460        470        480
PAAPGCVGVP GALPPPSPKL KDEDFPSLSA STSSSCSTAA TPGPVGLALP YAIPARGRSA
       490        500        510        520        530        540
FQEEDFPALV SSVPKPGTAP TSLVSAWNSS SSSKKVAQPP LSAQATGSGQ PTRKAGKGSR
       550        560        570        580        590        600
GGRKGGPPFT QEEEEDGGPA LQELLSTRPT GSVSSTLGLA SIQPSKVGKK KKVGSEKPGT
       610        620        630        640        650        660
TLPQPPPATC PPGALQAPEA PASRAEGPVA VVVNGHTEGP APARSAPKEP PGLPRPLGSF
       670        680        690        700        710        720
PCPTPQEDFP ALGGPCPPRM PPPPGFSAVV LLKGTPPPPP PGLVPPISKP PPGFSGLLPS
       730        740        750        760        770        780
PHPACVPSPA TTTTTKAPRL LPAPRAYLVP ENFRERNLQL IQSIRDFLQS DEARFSEFKS
       790        800        810        820        830        840
HSGEFRQGLI SAAQYYKSCR DLLGENFQKV FNELLVLLPD TAKQQELLSA HTDFCNREKP
       850        860        870        880        890        900
LSTKSKKNKK SAWQATTQQA GLDCRVCPTC QQVLAHGDAS SHQALHAARD DDFPSLQAIA

RIIT         10         20         30         40         50         60
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY RCSTKMRVLC
        70         80         90        100        110        120
EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI YFADGKVYAL YRQLLQHECP
       130        140        150        160        170        180
RCPELPPFSL FGDLEQHMRR QHELFCCRLC LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD
       190        200        210        220        230        240
TSHRGHPLCK FCDERYLDND ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF
       250        260        270        280        290        300
LCEEGRCSTE QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV
       310        320        330        340        350        360
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR ASVAAQQQEE
       370        380        390        400        410        420
ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP GPKETSTNGP VSQEAFSVTG
       430        440        450        460        470        480
PAAPGCVGVP GALPPPSPKL KDEDFPSLSA STSSSCSTAA TPGPVGLALP YAIPARGRSA
       490        500        510        520        530        540
FQEEDFPALV SSVPKPGTAP TSLVSAWNSS SSSKKVAQPP LSAQATGSGQ PTRKAGKGSR
       550        560        570        580        590        600
GGRKGGPPFT QEEEEDGGPA LQELLSTRPT GSVSSTLGLA SIQPSKVGKK KKVGSEKPGT
       610        620        630        640        650        660
TLPQPPPATC PPGALQAPEA PASRAEGPVA VVVNGHTEGP APARSAPKEP PGLPRPLGSF
       670        680        690        700        710        720
PCPTPQEDFP ALGGPCPPRM PPPPGFSAVV LLKGTPPPPP PGLVPPISKP PPGFSGLLPS
       730        740        750        760        770        780
PHPACVPSPA TTTTTKAPRL LPAPRAYLVP ENFRERNLQL IQSIRDFLQS DEARFSEFKS
       790        800        810        820        830        840
HSGEFRQGLI SAAQYYKSCR DLLGENFQKV FNELLVLLPD TAKQQELLSA HTDFCNREKP
       850        860        870        880        890        900
LSTKSKKNKK SAWQATTQQA GLDCRVCPTC QQVLAHGDAS SHQALHAARD DDFPSLQAIA

RIIT         10         20         30         40         50         60
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY RCSTKMRVLC
        70         80         90        100        110        120
EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI YFADGKVYAL YRQLLQHECP
       130        140        150        160        170        180
RCPELPPFSL FGDLEQHMRR QHELFCCRLC LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD
       190        200        210        220        230        240
TSHRGHPLCK FCDERYLDND ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF
       250        260        270        280        290        300
LCEEGRCSTE QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV
       310        320        330        340        350        360
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR ASVAAQQQEE
       370        380        390        400        410        420
ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP GPKETSTNGP VSQEAFSVTG
       430        440        450        460        470        480
PAAPGCVGVP GALPPPSPKL KDEDFPSLSA STSSSCSTAA TPGPVGLALP YAIPARGRSA
       490        500        510        520        530        540
FQEEDFPALV SSVPKPGTAP TSLVSAWNSS SSSKKVAQPP LSAQATGSGQ PTRKAGKGSR
       550        560        570        580        590        600
GGRKGGPPFT QEEEEDGGPA LQELLSTRPT GSVSSTLGLA SIQPSKVGKK KKVGSEKPGT
       610        620        630        640        650        660
TLPQPPPATC PPGALQAPEA PASRAEGPVA VVVNGHTEGP APARSAPKEP PGLPRPLGSF
       670        680        690        700        710        720
PCPTPQEDFP ALGGPCPPRM PPPPGFSAVV LLKGTPPPPP PGLVPPISKP PPGFSGLLPS
       730        740        750        760        770        780
PHPACVPSPA TTTTTKAPRL LPAPRAYLVP ENFRERNLQL IQSIRDFLQS DEARFSEFKS
       790        800        810        820        830        840
HSGEFRQGLI SAAQYYKSCR DLLGENFQKV FNELLVLLPD TAKQQELLSA HTDFCNREKP
       850        860        870        880        890        900
LSTKSKKNKK SAWQATTQQA GLDCRVCPTC QQVLAHGDAS SHQALHAARD DDFPSLQAIA

RIIT         10         20         30         40         50         60
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY RCSTKMRVLC
        70         80         90        100        110        120
EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI YFADGKVYAL YRQLLQHECP
       130        140        150        160        170        180
RCPELPPFSL FGDLEQHMRR QHELFCCRLC LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD
       190        200        210        220        230        240
TSHRGHPLCK FCDERYLDND ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF
       250        260        270        280        290        300
LCEEGRCSTE QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV
       310        320        330        340        350        360
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR ASVAAQQQEE
       370        380        390        400        410        420
ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP GPKETSTNGP VSQEAFSVTG
       430        440        450        460        470        480
PAAPGCVGVP GALPPPSPKL KDEDFPSLSA STSSSCSTAA TPGPVGLALP YAIPARGRSA
       490        500        510        520        530        540
FQEEDFPALV SSVPKPGTAP TSLVSAWNSS SSSKKVAQPP LSAQATGSGQ PTRKAGKGSR
       550        560        570        580        590        600
GGRKGGPPFT QEEEEDGGPA LQELLSTRPT GSVSSTLGLA SIQPSKVGKK KKVGSEKPGT
       610        620        630        640        650        660
TLPQPPPATC PPGALQAPEA PASRAEGPVA VVVNGHTEGP APARSAPKEP PGLPRPLGSF
       670        680        690        700        710        720
PCPTPQEDFP ALGGPCPPRM PPPPGFSAVV LLKGTPPPPP PGLVPPISKP PPGFSGLLPS
       730        740        750        760        770        780
PHPACVPSPA TTTTTKAPRL LPAPRAYLVP ENFRERNLQL IQSIRDFLQS DEARFSEFKS
       790        800        810        820        830        840
HSGEFRQGLI SAAQYYKSCR DLLGENFQKV FNELLVLLPD TAKQQELLSA HTDFCNREKP
       850        860        870        880        890        900
LSTKSKKNKK SAWQATTQQA GLDCRVCPTC QQVLAHGDAS SHQALHAARD DDFPSLQAIA

RIIT         10         20         30         40         50         60
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY RCSTKMRVLC
        70         80         90        100        110        120
EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI YFADGKVYAL YRQLLQHECP
       130        140        150        160        170        180
RCPELPPFSL FGDLEQHMRR QHELFCCRLC LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD
       190        200        210        220        230        240
TSHRGHPLCK FCDERYLDND ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF
       250        260        270        280        290        300
LCEEGRCSTE QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV
       310        320        330        340        350        360
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR ASVAAQQQEE
       370        380        390        400        410        420
ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP GPKETSTNGP VSQEAFSVTG
       430        440        450        460        470        480
PAAPGCVGVP GALPPPSPKL KDEDFPSLSA STSSSCSTAA TPGPVGLALP YAIPARGRSA
       490        500        510        520        530        540
FQEEDFPALV SSVPKPGTAP TSLVSAWNSS SSSKKVAQPP LSAQATGSGQ PTRKAGKGSR
       550        560        570        580        590        600
GGRKGGPPFT QEEEEDGGPA LQELLSTRPT GSVSSTLGLA SIQPSKVGKK KKVGSEKPGT
       610        620        630        640        650        660
TLPQPPPATC PPGALQAPEA PASRAEGPVA VVVNGHTEGP APARSAPKEP PGLPRPLGSF
       670        680        690        700        710        720
PCPTPQEDFP ALGGPCPPRM PPPPGFSAVV LLKGTPPPPP PGLVPPISKP PPGFSGLLPS
       730        740        750        760        770        780
PHPACVPSPA TTTTTKAPRL LPAPRAYLVP ENFRERNLQL IQSIRDFLQS DEARFSEFKS
       790        800        810        820        830        840
HSGEFRQGLI SAAQYYKSCR DLLGENFQKV FNELLVLLPD TAKQQELLSA HTDFCNREKP
       850        860        870        880        890        900
LSTKSKKNKK SAWQATTQQA GLDCRVCPTC QQVLAHGDAS SHQALHAARD DDFPSLQAIA

RIIT         10         20         30         40         50         60
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY RCSTKMRVLC
        70         80         90        100        110        120
EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI YFADGKVYAL YRQLLQHECP
       130        140        150        160        170        180
RCPELPPFSL FGDLEQHMRR QHELFCCRLC LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD
       190        200        210        220        230        240
TSHRGHPLCK FCDERYLDND ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF
       250        260        270        280        290        300
LCEEGRCSTE QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV
       310        320        330        340        350        360
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR ASVAAQQQEE
       370        380        390        400        410        420
ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP GPKETSTNGP VSQEAFSVTG
       430        440        450        460        470        480
PAAPGCVGVP GALPPPSPKL KDEDFPSLSA STSSSCSTAA TPGPVGLALP YAIPARGRSA
       490        500        510        520        530        540
FQEEDFPALV SSVPKPGTAP TSLVSAWNSS SSSKKVAQPP LSAQATGSGQ PTRKAGKGSR
       550        560        570        580        590        600
GGRKGGPPFT QEEEEDGGPA LQELLSTRPT GSVSSTLGLA SIQPSKVGKK KKVGSEKPGT
       610        620        630        640        650        660
TLPQPPPATC PPGALQAPEA PASRAEGPVA VVVNGHTEGP APARSAPKEP PGLPRPLGSF
       670        680        690        700        710        720
PCPTPQEDFP ALGGPCPPRM PPPPGFSAVV LLKGTPPPPP PGLVPPISKP PPGFSGLLPS
       730        740        750        760        770        780
PHPACVPSPA TTTTTKAPRL LPAPRAYLVP ENFRERNLQL IQSIRDFLQS DEARFSEFKS
       790        800        810        820        830        840
HSGEFRQGLI SAAQYYKSCR DLLGENFQKV FNELLVLLPD TAKQQELLSA HTDFCNREKP
       850        860        870        880        890        900
LSTKSKKNKK SAWQATTQQA GLDCRVCPTC QQVLAHGDAS SHQALHAARD DDFPSLQAIA

RIIT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86UK7-1-unknown	MAAAGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86UK7-1-unknown	MAAAGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95461
Q86UK7-1-unknown	MAAAGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95462
Q86UK7-15-unknown	EAAAAA...	15	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14687
Q86UK7-15-unknown	EAAAAA...	15	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136538
Q86UK7-15-unknown	EAAAAA...	15	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136539
Q86UK7-56-unknown	MRVLCE...	56	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455882
Q86UK7-56-unknown	MRVLCE...	56	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455308
Q86UK7-56-unknown	MRVLCE...	56	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132732
Q86UK7-56-unknown	MRVLCE...	56	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132733
Q86UK7-351-unknown	ASVAAQ...	351	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10404
Q86UK7-351-unknown	ASVAAQ...	351	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150907
Q86UK7-351-unknown	ASVAAQ...	351	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150962
Q86UK7-458-	TAATPG...	458		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q86UK7-458-unknown	TAATPG...	458	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167849
Q86UK7-458-unknown	TAATPG...	458	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167851
Q86UK7-458-unknown	TAATPG...	458	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167850
Q86UK7-560-unknown	ALQELL...	560	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165608
Q86UK7-560-unknown	ALQELL...	560	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165610
Q86UK7-560-unknown	ALQELL...	560	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165609
Q86UK7-560-	ALQELL...	560		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRAALE	14	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14687
...AAAVRA	350	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10404
...AAAVRA	350	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134365
...TTTKAP	737	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91081
...TTTKAP	737	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92456
...TTTKAP	737	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92455
...ARIIT	904	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ARIIT	904	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91079
...ARIIT	904	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91080

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	14	AALE.\|.EAAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	350	AVRA.\|.ASVA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)