Q86V48: Leucine zipper protein 1

General Information

Protein names	- Leucine zipper protein 1
Gene names	LUZP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86V48

10 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Leucine zipper protein 1 - Isoform 3 of Leucine zipper protein 1

Sequence View

        10         20         30         40         50         60
MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK VIQAEGSNSS
        70         80         90        100        110        120
MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE NLTRELKSEI ERLQKRMAEL
       130        140        150        160        170        180
EKLEEAFSRS KNDCTQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLA
       190        200        210        220        230        240
SELEKLKSLT LSFVSERKYL NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL
       250        260        270        280        290        300
RIEDGISSTL PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT
       310        320        330        340        350        360
QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ KELENGEVEG
       370        380        390        400        410        420
EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE RLRNREFALN NENYSLSNRQ
       430        440        450        460        470        480
VSSPSFTNRR AAKASHMGVS TDSGTQETKK TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA
       490        500        510        520        530        540
AQEHSKAWKG TSKPGTESGL KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG
       550        560        570        580        590        600
KRGHVLGNGS QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP
       610        620        630        640        650        660
VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK SSGREKPDSD
       670        680        690        700        710        720
DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP RTSLFENDKD AGMENESVKS
       730        740        750        760        770        780
VRASTNTMEL PDTNGAGVKS QRPFSPREAL RSRAIIKPVI VDKDVKKIMG GSGTETTLEK
       790        800        810        820        830        840
QKPVSKPGPN KVTSSITIYP SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS
       850        860        870        880        890        900
PFELSIHKHD ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR
       910        920        930        940        950        960
WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN AYTQRSSTDF
       970        980        990       1000       1010       1020
SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS EVLTRRNRVG DTITVAAWNH
      1030       1040       1050       1060       1070
SASMEEEGED CTLSVYRQLH NSLDPSELPG KQGLPESGRV RAEERLRPTR PCAEEN         10         20         30         40         50         60
MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK VIQAEGSNSS
        70         80         90        100        110        120
MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE NLTRELKSEI ERLQKRMAEL
       130        140        150        160        170        180
EKLEEAFSRS KNDCTQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLA
       190        200        210        220        230        240
SELEKLKSLT LSFVSERKYL NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL
       250        260        270        280        290        300
RIEDGISSTL PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT
       310        320        330        340        350        360
QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ KELENGEVEG
       370        380        390        400        410        420
EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE RLRNREFALN NENYSLSNRQ
       430        440        450        460        470        480
VSSPSFTNRR AAKASHMGVS TDSGTQETKK TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA
       490        500        510        520        530        540
AQEHSKAWKG TSKPGTESGL KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG
       550        560        570        580        590        600
KRGHVLGNGS QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP
       610        620        630        640        650        660
VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK SSGREKPDSD
       670        680        690        700        710        720
DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP RTSLFENDKD AGMENESVKS
       730        740        750        760        770        780
VRASTNTMEL PDTNGAGVKS QRPFSPREAL RSRAIIKPVI VDKDVKKIMG GSGTETTLEK
       790        800        810        820        830        840
QKPVSKPGPN KVTSSITIYP SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS
       850        860        870        880        890        900
PFELSIHKHD ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR
       910        920        930        940        950        960
WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN AYTQRSSTDF
       970        980        990       1000       1010       1020
SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS EVLTRRNRVG DTITVAAWNH
      1030       1040       1050       1060       1070
SASMEEEGED CTLSVYRQLH NSLDPSELPG KQGLPESGRV RAEERLRPTR PCAEEN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86V48-1-unknown	MAEFTS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80080
Q86V48-1-unknown	MAEFTS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80081
Q86V48-2-unknown	MAEFTS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86V48-2-Acetylation	AEFTSY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86V48-2-Acetylation	AEFTSY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q86V48-2-Acetylation	AEFTSY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q86V48-2-Acetylation	AEFTSY...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110740
Q86V48-2-Acetylation	AEFTSY...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110741
Q86V48-443-unknown	SGTQET...	443		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12758
Q86V48-443-unknown	SGTQET...	443		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152691
Q86V48-443-unknown	SGTQET...	443		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152692
Q86V48-512-unknown	SDTTHG...	512		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169871
Q86V48-512-unknown	SDTTHG...	512		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169872
Q86V48-512-	SDTTHG...	512			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86V48-905-	SAPSEV...	905			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q86V48-905-unknown	SAPSEV...	905		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178330
Q86V48-905-unknown	SAPSEV...	905		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178331
Q86V48-956-unknown	SSTDFS...	956		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172730
Q86V48-956-unknown	SSTDFS...	956		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172731
Q86V48-956-	SSTDFS...	956			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVSTDS	442	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12758
...GVSTDS	442	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136110
...GVSTDS	442	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136111
...CAEEN	1076	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	442	STDS.\|.SGTQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)