Q86Y91: Kinesin-like protein KIF18B

General Information

Protein names	- Kinesin-like protein KIF18B
Gene names	KIF18B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86Y91

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Kinesin-like protein KIF18B - Isoform 3 of Kinesin-like protein KIF18B - Isoform 4 of Kinesin-like protein KIF18B - Isoform 2 of Kinesin-like protein KIF18B

Sequence View

        10         20         30         40         50         60
MAVEDSTLQV VVRVRPPTPR ELDSQRRPVV QVVDERVLVF NPEEPDGGFP GLKWGGTHDG
        70         80         90        100        110        120
PKKKGKDLTF VFDRVFGEAA TQQDVFQHTT HSVLDSFLQG YNCSVFAYGA TGAGKTHTML
       130        140        150        160        170        180
GREGDPGIMY LTTVELYRRL EARQQEKHFE VLISYQEVYN EQIHDLLEPK GPLAIREDPD
       190        200        210        220        230        240
KGVVVQGLSF HQPASAEQLL EILTRGNRNR TQHPTDANAT SSRSHAIFQI FVKQQDRVPG
       250        260        270        280        290        300
LTQAVQVAKM SLIDLAGSER ASSTHAKGER LREGANINRS LLALINVLNA LADAKGRKTH
       310        320        330        340        350        360
VPYRDSKLTR LLKDSLGGNC RTVMIAAISP SSLTYEDTYN TLKYADRAKE IRLSLKSNVT
       370        380        390        400        410        420
SLDCHISQYA TICQQLQAEV AALRKKLQVY EGGGQPPPQD LPGSPKSGPP PEHQPCTPEL
       430        440        450        460        470        480
PAGPRALQEE SLGMEAQVER AMEGNSSDQE QSPEDEDEGP AEEVPTQMPE QNPTHALPES
       490        500        510        520        530        540
PRLTLQPKPV VGHFSARELD GDRSKQLALK VLCVAQRQYS LLQAANLLTP DMITEFETLQ
       550        560        570        580        590        600
QLVQEEKIEP GAEALRTSGL ARGAPLAQEL CSESIPVPSP LCPEPPGYTG PVTRTMARRL
       610        620        630        640        650        660
SGPLHTLGIP PGPNCTPAQG SRWPMEKKRR RPSALEADSP MAPKRGTKRQ RQSFLPCLRR
       670        680        690        700        710        720
GSLPDTQPSQ GPSTPKGERA SSPCHSPRVC PATVIKSRVP LGPSAMQNCS TPLALPTRDL
       730        740        750        760        770        780
NATFDLSEEP PSKPSFHECI GWDKIPQELS RLDQPFIPRA PVPLFTMKGP KPTSSLPGTS
       790        800        810        820        830        840
ACKKKRVASS SVSHGRSRIA RLPSSTLKRP AGPLVLPELP LSPLCPSNRR NGKDLIRVGR
       850
ALSAGNGVTK VS         10         20         30         40         50         60
MAVEDSTLQV VVRVRPPTPR ELDSQRRPVV QVVDERVLVF NPEEPDGGFP GLKWGGTHDG
        70         80         90        100        110        120
PKKKGKDLTF VFDRVFGEAA TQQDVFQHTT HSVLDSFLQG YNCSVFAYGA TGAGKTHTML
       130        140        150        160        170        180
GREGDPGIMY LTTVELYRRL EARQQEKHFE VLISYQEVYN EQIHDLLEPK GPLAIREDPD
       190        200        210        220        230        240
KGVVVQGLSF HQPASAEQLL EILTRGNRNR TQHPTDANAT SSRSHAIFQI FVKQQDRVPG
       250        260        270        280        290        300
LTQAVQVAKM SLIDLAGSER ASSTHAKGER LREGANINRS LLALINVLNA LADAKGRKTH
       310        320        330        340        350        360
VPYRDSKLTR LLKDSLGGNC RTVMIAAISP SSLTYEDTYN TLKYADRAKE IRLSLKSNVT
       370        380        390        400        410        420
SLDCHISQYA TICQQLQAEV AALRKKLQVY EGGGQPPPQD LPGSPKSGPP PEHQPCTPEL
       430        440        450        460        470        480
PAGPRALQEE SLGMEAQVER AMEGNSSDQE QSPEDEDEGP AEEVPTQMPE QNPTHALPES
       490        500        510        520        530        540
PRLTLQPKPV VGHFSARELD GDRSKQLALK VLCVAQRQYS LLQAANLLTP DMITEFETLQ
       550        560        570        580        590        600
QLVQEEKIEP GAEALRTSGL ARGAPLAQEL CSESIPVPSP LCPEPPGYTG PVTRTMARRL
       610        620        630        640        650        660
SGPLHTLGIP PGPNCTPAQG SRWPMEKKRR RPSALEADSP MAPKRGTKRQ RQSFLPCLRR
       670        680        690        700        710        720
GSLPDTQPSQ GPSTPKGERA SSPCHSPRVC PATVIKSRVP LGPSAMQNCS TPLALPTRDL
       730        740        750        760        770        780
NATFDLSEEP PSKPSFHECI GWDKIPQELS RLDQPFIPRA PVPLFTMKGP KPTSSLPGTS
       790        800        810        820        830        840
ACKKKRVASS SVSHGRSRIA RLPSSTLKRP AGPLVLPELP LSPLCPSNRR NGKDLIRVGR
       850
ALSAGNGVTK VS         10         20         30         40         50         60
MAVEDSTLQV VVRVRPPTPR ELDSQRRPVV QVVDERVLVF NPEEPDGGFP GLKWGGTHDG
        70         80         90        100        110        120
PKKKGKDLTF VFDRVFGEAA TQQDVFQHTT HSVLDSFLQG YNCSVFAYGA TGAGKTHTML
       130        140        150        160        170        180
GREGDPGIMY LTTVELYRRL EARQQEKHFE VLISYQEVYN EQIHDLLEPK GPLAIREDPD
       190        200        210        220        230        240
KGVVVQGLSF HQPASAEQLL EILTRGNRNR TQHPTDANAT SSRSHAIFQI FVKQQDRVPG
       250        260        270        280        290        300
LTQAVQVAKM SLIDLAGSER ASSTHAKGER LREGANINRS LLALINVLNA LADAKGRKTH
       310        320        330        340        350        360
VPYRDSKLTR LLKDSLGGNC RTVMIAAISP SSLTYEDTYN TLKYADRAKE IRLSLKSNVT
       370        380        390        400        410        420
SLDCHISQYA TICQQLQAEV AALRKKLQVY EGGGQPPPQD LPGSPKSGPP PEHQPCTPEL
       430        440        450        460        470        480
PAGPRALQEE SLGMEAQVER AMEGNSSDQE QSPEDEDEGP AEEVPTQMPE QNPTHALPES
       490        500        510        520        530        540
PRLTLQPKPV VGHFSARELD GDRSKQLALK VLCVAQRQYS LLQAANLLTP DMITEFETLQ
       550        560        570        580        590        600
QLVQEEKIEP GAEALRTSGL ARGAPLAQEL CSESIPVPSP LCPEPPGYTG PVTRTMARRL
       610        620        630        640        650        660
SGPLHTLGIP PGPNCTPAQG SRWPMEKKRR RPSALEADSP MAPKRGTKRQ RQSFLPCLRR
       670        680        690        700        710        720
GSLPDTQPSQ GPSTPKGERA SSPCHSPRVC PATVIKSRVP LGPSAMQNCS TPLALPTRDL
       730        740        750        760        770        780
NATFDLSEEP PSKPSFHECI GWDKIPQELS RLDQPFIPRA PVPLFTMKGP KPTSSLPGTS
       790        800        810        820        830        840
ACKKKRVASS SVSHGRSRIA RLPSSTLKRP AGPLVLPELP LSPLCPSNRR NGKDLIRVGR
       850
ALSAGNGVTK VS         10         20         30         40         50         60
MAVEDSTLQV VVRVRPPTPR ELDSQRRPVV QVVDERVLVF NPEEPDGGFP GLKWGGTHDG
        70         80         90        100        110        120
PKKKGKDLTF VFDRVFGEAA TQQDVFQHTT HSVLDSFLQG YNCSVFAYGA TGAGKTHTML
       130        140        150        160        170        180
GREGDPGIMY LTTVELYRRL EARQQEKHFE VLISYQEVYN EQIHDLLEPK GPLAIREDPD
       190        200        210        220        230        240
KGVVVQGLSF HQPASAEQLL EILTRGNRNR TQHPTDANAT SSRSHAIFQI FVKQQDRVPG
       250        260        270        280        290        300
LTQAVQVAKM SLIDLAGSER ASSTHAKGER LREGANINRS LLALINVLNA LADAKGRKTH
       310        320        330        340        350        360
VPYRDSKLTR LLKDSLGGNC RTVMIAAISP SSLTYEDTYN TLKYADRAKE IRLSLKSNVT
       370        380        390        400        410        420
SLDCHISQYA TICQQLQAEV AALRKKLQVY EGGGQPPPQD LPGSPKSGPP PEHQPCTPEL
       430        440        450        460        470        480
PAGPRALQEE SLGMEAQVER AMEGNSSDQE QSPEDEDEGP AEEVPTQMPE QNPTHALPES
       490        500        510        520        530        540
PRLTLQPKPV VGHFSARELD GDRSKQLALK VLCVAQRQYS LLQAANLLTP DMITEFETLQ
       550        560        570        580        590        600
QLVQEEKIEP GAEALRTSGL ARGAPLAQEL CSESIPVPSP LCPEPPGYTG PVTRTMARRL
       610        620        630        640        650        660
SGPLHTLGIP PGPNCTPAQG SRWPMEKKRR RPSALEADSP MAPKRGTKRQ RQSFLPCLRR
       670        680        690        700        710        720
GSLPDTQPSQ GPSTPKGERA SSPCHSPRVC PATVIKSRVP LGPSAMQNCS TPLALPTRDL
       730        740        750        760        770        780
NATFDLSEEP PSKPSFHECI GWDKIPQELS RLDQPFIPRA PVPLFTMKGP KPTSSLPGTS
       790        800        810        820        830        840
ACKKKRVASS SVSHGRSRIA RLPSSTLKRP AGPLVLPELP LSPLCPSNRR NGKDLIRVGR
       850
ALSAGNGVTK VS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86Y91-1-unknown	MAVEDS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86Y91-1-unknown	MAVEDS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78924
Q86Y91-1-unknown	MAVEDS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78925
Q86Y91-1-unknown	MAVEDS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78926
Q86Y91-1-unknown	MAVEDS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131453
Q86Y91-1-unknown	MAVEDS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131454
Q86Y91-1-unknown	MAVEDS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131455
Q86Y91-2-acetylation	AVEDST...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q86Y91-2-acetylation	AVEDST...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178845
Q86Y91-2-acetylation	AVEDST...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178846
Q86Y91-2-acetylation	AVEDST...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178847
Q86Y91-10-unknown	VVVRVR...	10		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465377
Q86Y91-10-unknown	VVVRVR...	10		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465992
Q86Y91-10-unknown	VVVRVR...	10		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000341466
Q86Y91-10-unknown	VVVRVR...	10		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412798
Q86Y91-10-unknown	VVVRVR...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131453
Q86Y91-10-unknown	VVVRVR...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131454
Q86Y91-10-unknown	VVVRVR...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131455
Q86Y91-11-unknown	VVRVRP...	11		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168097
Q86Y91-11-unknown	VVRVRP...	11		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168098
Q86Y91-11-unknown	VVRVRP...	11		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168099
Q86Y91-11-	VVRVRP...	11			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q86Y91-11-	VVRVRP...	11			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86Y91-447-unknown	SDQEQS...	447		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10408
Q86Y91-447-unknown	SDQEQS...	447		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152555
Q86Y91-447-unknown	SDQEQS...	447		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152759
Q86Y91-447-unknown	SDQEQS...	447		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152760

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MEGNSS	446	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10408
...	864	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...	864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74543
...	864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74544

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	446	GNSS.\|.SDQE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)