Q86YP4: Transcriptional repressor p66-alpha
Protein names | - Transcriptional repressor p66-alpha - Hp66alpha - GATA zinc finger domain-containing protein 2A |
---|---|
Gene names | GATAD2A |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q86YP4 |
8
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MTEEACRTRS QKRALERDPT EDDVESKKIK MERGLLASDL NTDGDMRVTP EPGAGPTQGL
70 80 90 100 110 120
LRATEATAMA MGRGEGLVGD GPVDMRTSHS DMKSERRPPS PDVIVLSDNE QPSSPRVNGL
130 140 150 160 170 180
TTVALKETST EALMKSSPEE RERMIKQLKE ELRLEEAKLV LLKKLRQSQI QKEATAQKPT
190 200 210 220 230 240
GSVGSTVTTP PPLVRGTQNI PAGKPSLQTS SARMPGSVIP PPLVRGGQQA SSKLGPQASS
250 260 270 280 290 300
QVVMPPLVRG AQQIHSIRQH SSTGPPPLLL APRASVPSVQ IQGQRIIQQG LIRVANVPNT
310 320 330 340 350 360
SLLVNIPQPT PASLKGTTAT SAQANSTPTS VASVVTSAES PASRQAAAKL ALRKQLEKTL
370 380 390 400 410 420
LEIPPPKPPA PEMNFLPSAA NNEFIYLVGL EEVVQNLLET QGRMSAATVL SREPYMCAQC
430 440 450 460 470 480
KTDFTCRWRE EKSGAIMCEN CMTTNQKKAL KVEHTSRLKA AFVKALQQEQ EIEQRLLQQG
490 500 510 520 530 540
TAPAQAKAEP TAAPHPVLKQ VIKPRRKLAF RSGEARDWSN GAVLQASSQL SRGSATTPRG
550 560 570 580 590 600
VLHTFSPSPK LQNSASATAL VSRTGRHSER TVSAGKGSAT SNWKKTPLST GGTLAFVSPS
610 620 630
LAVHKSSSAV DRQREYLLDM IPPRSIPQSA TWK
Isoforms
- Isoform 2 of Transcriptional repressor p66-alpha - Isoform 3 of Transcriptional repressor p66-alphaSequence View
10 20 30 40 50 60
MTEEACRTRS QKRALERDPT EDDVESKKIK MERGLLASDL NTDGDMRVTP EPGAGPTQGL
70 80 90 100 110 120
LRATEATAMA MGRGEGLVGD GPVDMRTSHS DMKSERRPPS PDVIVLSDNE QPSSPRVNGL
130 140 150 160 170 180
TTVALKETST EALMKSSPEE RERMIKQLKE ELRLEEAKLV LLKKLRQSQI QKEATAQKPT
190 200 210 220 230 240
GSVGSTVTTP PPLVRGTQNI PAGKPSLQTS SARMPGSVIP PPLVRGGQQA SSKLGPQASS
250 260 270 280 290 300
QVVMPPLVRG AQQIHSIRQH SSTGPPPLLL APRASVPSVQ IQGQRIIQQG LIRVANVPNT
310 320 330 340 350 360
SLLVNIPQPT PASLKGTTAT SAQANSTPTS VASVVTSAES PASRQAAAKL ALRKQLEKTL
370 380 390 400 410 420
LEIPPPKPPA PEMNFLPSAA NNEFIYLVGL EEVVQNLLET QGRMSAATVL SREPYMCAQC
430 440 450 460 470 480
KTDFTCRWRE EKSGAIMCEN CMTTNQKKAL KVEHTSRLKA AFVKALQQEQ EIEQRLLQQG
490 500 510 520 530 540
TAPAQAKAEP TAAPHPVLKQ VIKPRRKLAF RSGEARDWSN GAVLQASSQL SRGSATTPRG
550 560 570 580 590 600
VLHTFSPSPK LQNSASATAL VSRTGRHSER TVSAGKGSAT SNWKKTPLST GGTLAFVSPS
610 620 630
LAVHKSSSAV DRQREYLLDM IPPRSIPQSA TWK
10 20 30 40 50 60
MTEEACRTRS QKRALERDPT EDDVESKKIK MERGLLASDL NTDGDMRVTP EPGAGPTQGL
70 80 90 100 110 120
LRATEATAMA MGRGEGLVGD GPVDMRTSHS DMKSERRPPS PDVIVLSDNE QPSSPRVNGL
130 140 150 160 170 180
TTVALKETST EALMKSSPEE RERMIKQLKE ELRLEEAKLV LLKKLRQSQI QKEATAQKPT
190 200 210 220 230 240
GSVGSTVTTP PPLVRGTQNI PAGKPSLQTS SARMPGSVIP PPLVRGGQQA SSKLGPQASS
250 260 270 280 290 300
QVVMPPLVRG AQQIHSIRQH SSTGPPPLLL APRASVPSVQ IQGQRIIQQG LIRVANVPNT
310 320 330 340 350 360
SLLVNIPQPT PASLKGTTAT SAQANSTPTS VASVVTSAES PASRQAAAKL ALRKQLEKTL
370 380 390 400 410 420
LEIPPPKPPA PEMNFLPSAA NNEFIYLVGL EEVVQNLLET QGRMSAATVL SREPYMCAQC
430 440 450 460 470 480
KTDFTCRWRE EKSGAIMCEN CMTTNQKKAL KVEHTSRLKA AFVKALQQEQ EIEQRLLQQG
490 500 510 520 530 540
TAPAQAKAEP TAAPHPVLKQ VIKPRRKLAF RSGEARDWSN GAVLQASSQL SRGSATTPRG
550 560 570 580 590 600
VLHTFSPSPK LQNSASATAL VSRTGRHSER TVSAGKGSAT SNWKKTPLST GGTLAFVSPS
610 620 630
LAVHKSSSAV DRQREYLLDM IPPRSIPQSA TWK
Protein Neighborhood
Domains & Features
8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q86YP4-1-unknown | MTEEAC... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q86YP4-1-unknown | MTEEAC... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt84093 | |||
Q86YP4-1-unknown | MTEEAC... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt84094 | |||
Q86YP4-72-unknown | GRGEGL... | 72 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173824 | |||
Q86YP4-72-unknown | GRGEGL... | 72 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173825 | |||
Q86YP4-72- | GRGEGL... | 72 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q86YP4-76- | GLVGDG... | 76 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q86YP4-76- | GLVGDG... | 76 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q86YP4-76-unknown | GLVGDG... | 76 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168058 | |||
Q86YP4-76-unknown | GLVGDG... | 76 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168059 | |||
Q86YP4-103-unknown | VIVLSD... | 103 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12771 | |||
Q86YP4-103-unknown | VIVLSD... | 103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142574 | |||
Q86YP4-103-unknown | VIVLSD... | 103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142575 | |||
Q86YP4-589-unknown | STGGTL... | 589 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q86YP4-589-unknown | STGGTL... | 589 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160031 | |||
Q86YP4-589-unknown | STGGTL... | 589 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160030 | |||
Q86YP4-589- | STGGTL... | 589 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...PPSPDV | 102 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12771 | |||
...PPSPDV | 102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125768 | |||
...PPSPDV | 102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125769 | |||
...SATWK | 633 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SATWK | 633 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt79711 | |||
...SATWK | 633 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt79712 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 102 | SPDV.|.VIVL | inferred from experiment | unknown | MEROPS | Merops GRAB_HUMAN -> P66A_HUMAN @102 | ||
GRAB_HUMAN | 102 | SPDV.|.VIVL | inferred from experiment | unknown | MEROPS | Gevaert K | Plasman K et al.:Probing the efficiency of prote... (S01.010) | 21048194, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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