Q86YS7: C2 domain-containing protein 5

General Information

Protein names	- C2 domain-containing protein 5 - C2 domain-containing phosphoprotein of 138 kDa
Gene names	C2CD5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86YS7

5 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of C2 domain-containing protein 5 - Isoform 3 of C2 domain-containing protein 5 - Isoform 4 of C2 domain-containing protein 5 - Isoform 5 of C2 domain-containing protein 5

Sequence View

        10         20         30         40         50         60
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ WNSEWFKFEV
        70         80         90        100        110        120
DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE AATVISGWFP IYDTIHGIRG
       130        140        150        160        170        180
EINVVVKVDL FNDLNRFRQS SCGVKFFCTT SIPKCYRAVI IHGFVEELVV NEDPEYQWID
       190        200        210        220        230        240
RIRTPRASNE ARQRLISLMS GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG
       250        260        270        280        290        300
TACTLDKLSS PAAFLPACNS PSKEMKEIPF NEDPNPNTHS SGPSTPLKNQ TYSFSPSKSY
       310        320        330        340        350        360
SRQSSSSDTD LSLTPKTGMG SGSAGKEGGP FKALLRQQTQ SALEQREFPF FTLTAFPPGF
       370        380        390        400        410        420
LVHVGGVVSA RSVKLLDRIH NPDEPETRDA WWAEIRQEIK SHAKALGCHA VVGYSESTSI
       430        440        450        460        470        480
CEEVCILSAS GTAAVLNPRF LQDGTVEGCL EQRLEENLPT RCGFCHIPYD ELNMPFPAHL
       490        500        510        520        530        540
TYCYNCRKQK VPDVLFTTID LPTDATVIGK GCLIQARLCR LKKKAQAEAN ATAISNLLPF
       550        560        570        580        590        600
MEYEVHTQLM NKLKLKGMNA LFGLRIQITV GENMLMGLAS ATGVYLAALP TPGGIQIAGK
       610        620        630        640        650        660
TPNDGSYEQH ISHMQKKIND TIAKNKELYE INPPEISEEI IGSPIPEPRQ RSRLLRSQSE
       670        680        690        700        710        720
SSDEVTELDL SHGKKDAFVL EIDDTDAMED VHSLLTDVPP PSGFYSCNTE IMPGINNWTS
       730        740        750        760        770        780
EIQMFTSVRV IRLSSLNLTN QALNKNFNDL CENLLKSLYF KLRSMIPCCL CHVNFTVSLP
       790        800        810        820        830        840
EDELIQVTVT AVAITFDKNQ ALQTTKTPVE KSLQRASTDN EELLQFPLEL CSDSLPSHPF
       850        860        870        880        890        900
PPAKAMTVEK ASPVGDGNFR NRSAPPCANS TVGVVKMTPL SFIPGAKITK YLGIINMFFI
       910        920        930        940        950        960
RETTSLREEG GVSGFLHAFI AEVFAMVRAH VAALGGNAVV SYIMKQCVFM ENPNKNQAQC
       970        980        990       1000
LINVSGDAVV FVRESDLEVV SSQQPTTNCQ SSCTEGEVTT         10         20         30         40         50         60
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ WNSEWFKFEV
        70         80         90        100        110        120
DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE AATVISGWFP IYDTIHGIRG
       130        140        150        160        170        180
EINVVVKVDL FNDLNRFRQS SCGVKFFCTT SIPKCYRAVI IHGFVEELVV NEDPEYQWID
       190        200        210        220        230        240
RIRTPRASNE ARQRLISLMS GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG
       250        260        270        280        290        300
TACTLDKLSS PAAFLPACNS PSKEMKEIPF NEDPNPNTHS SGPSTPLKNQ TYSFSPSKSY
       310        320        330        340        350        360
SRQSSSSDTD LSLTPKTGMG SGSAGKEGGP FKALLRQQTQ SALEQREFPF FTLTAFPPGF
       370        380        390        400        410        420
LVHVGGVVSA RSVKLLDRIH NPDEPETRDA WWAEIRQEIK SHAKALGCHA VVGYSESTSI
       430        440        450        460        470        480
CEEVCILSAS GTAAVLNPRF LQDGTVEGCL EQRLEENLPT RCGFCHIPYD ELNMPFPAHL
       490        500        510        520        530        540
TYCYNCRKQK VPDVLFTTID LPTDATVIGK GCLIQARLCR LKKKAQAEAN ATAISNLLPF
       550        560        570        580        590        600
MEYEVHTQLM NKLKLKGMNA LFGLRIQITV GENMLMGLAS ATGVYLAALP TPGGIQIAGK
       610        620        630        640        650        660
TPNDGSYEQH ISHMQKKIND TIAKNKELYE INPPEISEEI IGSPIPEPRQ RSRLLRSQSE
       670        680        690        700        710        720
SSDEVTELDL SHGKKDAFVL EIDDTDAMED VHSLLTDVPP PSGFYSCNTE IMPGINNWTS
       730        740        750        760        770        780
EIQMFTSVRV IRLSSLNLTN QALNKNFNDL CENLLKSLYF KLRSMIPCCL CHVNFTVSLP
       790        800        810        820        830        840
EDELIQVTVT AVAITFDKNQ ALQTTKTPVE KSLQRASTDN EELLQFPLEL CSDSLPSHPF
       850        860        870        880        890        900
PPAKAMTVEK ASPVGDGNFR NRSAPPCANS TVGVVKMTPL SFIPGAKITK YLGIINMFFI
       910        920        930        940        950        960
RETTSLREEG GVSGFLHAFI AEVFAMVRAH VAALGGNAVV SYIMKQCVFM ENPNKNQAQC
       970        980        990       1000
LINVSGDAVV FVRESDLEVV SSQQPTTNCQ SSCTEGEVTT         10         20         30         40         50         60
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ WNSEWFKFEV
        70         80         90        100        110        120
DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE AATVISGWFP IYDTIHGIRG
       130        140        150        160        170        180
EINVVVKVDL FNDLNRFRQS SCGVKFFCTT SIPKCYRAVI IHGFVEELVV NEDPEYQWID
       190        200        210        220        230        240
RIRTPRASNE ARQRLISLMS GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG
       250        260        270        280        290        300
TACTLDKLSS PAAFLPACNS PSKEMKEIPF NEDPNPNTHS SGPSTPLKNQ TYSFSPSKSY
       310        320        330        340        350        360
SRQSSSSDTD LSLTPKTGMG SGSAGKEGGP FKALLRQQTQ SALEQREFPF FTLTAFPPGF
       370        380        390        400        410        420
LVHVGGVVSA RSVKLLDRIH NPDEPETRDA WWAEIRQEIK SHAKALGCHA VVGYSESTSI
       430        440        450        460        470        480
CEEVCILSAS GTAAVLNPRF LQDGTVEGCL EQRLEENLPT RCGFCHIPYD ELNMPFPAHL
       490        500        510        520        530        540
TYCYNCRKQK VPDVLFTTID LPTDATVIGK GCLIQARLCR LKKKAQAEAN ATAISNLLPF
       550        560        570        580        590        600
MEYEVHTQLM NKLKLKGMNA LFGLRIQITV GENMLMGLAS ATGVYLAALP TPGGIQIAGK
       610        620        630        640        650        660
TPNDGSYEQH ISHMQKKIND TIAKNKELYE INPPEISEEI IGSPIPEPRQ RSRLLRSQSE
       670        680        690        700        710        720
SSDEVTELDL SHGKKDAFVL EIDDTDAMED VHSLLTDVPP PSGFYSCNTE IMPGINNWTS
       730        740        750        760        770        780
EIQMFTSVRV IRLSSLNLTN QALNKNFNDL CENLLKSLYF KLRSMIPCCL CHVNFTVSLP
       790        800        810        820        830        840
EDELIQVTVT AVAITFDKNQ ALQTTKTPVE KSLQRASTDN EELLQFPLEL CSDSLPSHPF
       850        860        870        880        890        900
PPAKAMTVEK ASPVGDGNFR NRSAPPCANS TVGVVKMTPL SFIPGAKITK YLGIINMFFI
       910        920        930        940        950        960
RETTSLREEG GVSGFLHAFI AEVFAMVRAH VAALGGNAVV SYIMKQCVFM ENPNKNQAQC
       970        980        990       1000
LINVSGDAVV FVRESDLEVV SSQQPTTNCQ SSCTEGEVTT         10         20         30         40         50         60
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ WNSEWFKFEV
        70         80         90        100        110        120
DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE AATVISGWFP IYDTIHGIRG
       130        140        150        160        170        180
EINVVVKVDL FNDLNRFRQS SCGVKFFCTT SIPKCYRAVI IHGFVEELVV NEDPEYQWID
       190        200        210        220        230        240
RIRTPRASNE ARQRLISLMS GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG
       250        260        270        280        290        300
TACTLDKLSS PAAFLPACNS PSKEMKEIPF NEDPNPNTHS SGPSTPLKNQ TYSFSPSKSY
       310        320        330        340        350        360
SRQSSSSDTD LSLTPKTGMG SGSAGKEGGP FKALLRQQTQ SALEQREFPF FTLTAFPPGF
       370        380        390        400        410        420
LVHVGGVVSA RSVKLLDRIH NPDEPETRDA WWAEIRQEIK SHAKALGCHA VVGYSESTSI
       430        440        450        460        470        480
CEEVCILSAS GTAAVLNPRF LQDGTVEGCL EQRLEENLPT RCGFCHIPYD ELNMPFPAHL
       490        500        510        520        530        540
TYCYNCRKQK VPDVLFTTID LPTDATVIGK GCLIQARLCR LKKKAQAEAN ATAISNLLPF
       550        560        570        580        590        600
MEYEVHTQLM NKLKLKGMNA LFGLRIQITV GENMLMGLAS ATGVYLAALP TPGGIQIAGK
       610        620        630        640        650        660
TPNDGSYEQH ISHMQKKIND TIAKNKELYE INPPEISEEI IGSPIPEPRQ RSRLLRSQSE
       670        680        690        700        710        720
SSDEVTELDL SHGKKDAFVL EIDDTDAMED VHSLLTDVPP PSGFYSCNTE IMPGINNWTS
       730        740        750        760        770        780
EIQMFTSVRV IRLSSLNLTN QALNKNFNDL CENLLKSLYF KLRSMIPCCL CHVNFTVSLP
       790        800        810        820        830        840
EDELIQVTVT AVAITFDKNQ ALQTTKTPVE KSLQRASTDN EELLQFPLEL CSDSLPSHPF
       850        860        870        880        890        900
PPAKAMTVEK ASPVGDGNFR NRSAPPCANS TVGVVKMTPL SFIPGAKITK YLGIINMFFI
       910        920        930        940        950        960
RETTSLREEG GVSGFLHAFI AEVFAMVRAH VAALGGNAVV SYIMKQCVFM ENPNKNQAQC
       970        980        990       1000
LINVSGDAVV FVRESDLEVV SSQQPTTNCQ SSCTEGEVTT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86YS7-1-unknown	MPGKLK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86YS7-1-unknown	MPGKLK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68826
Q86YS7-1-unknown	MPGKLK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68827
Q86YS7-199-unknown	MSGELQ...	199	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445288
Q86YS7-199-unknown	MSGELQ...	199	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198042
Q86YS7-199-unknown	MSGELQ...	199	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198043
Q86YS7-202-unknown	ELQRKI...	202	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443479
Q86YS7-202-unknown	ELQRKI...	202	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198065
Q86YS7-202-unknown	ELQRKI...	202	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198066
Q86YS7-834-	SLPSHP...	834		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86YS7-834-unknown	SLPSHP...	834	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12774

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SVKLLD	376	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000443479
...LTYCYN	484	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444857
...ELCSDS	833	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12774
...ELCSDS	833	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140070
...ELCSDS	833	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140112
...EVVSSQ	982	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437935
...GEVTT	1000	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GEVTT	1000	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64444
...GEVTT	1000	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64445

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	833	CSDS.\|.SLPS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)