Q8C2B3: Histone deacetylase 7

General Information

Protein names	- Histone deacetylase 7 - HD7 - 3.5.1.98 - Histone deacetylase 7A - HD7a
Gene names	Hdac7
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8C2B3

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Histone deacetylase 7 - Isoform 3 of Histone deacetylase 7 - Isoform 4 of Histone deacetylase 7 - Isoform 5 of Histone deacetylase 7 - Isoform 6 of Histone deacetylase 7

Sequence View

        10         20         30         40         50         60
MHSPGAGCPA LQPDTPGSQP QPMDLRVGQR PTVEPPPEPA LLTLQHPQRL HRHLFLAGLH
        70         80         90        100        110        120
QQQRSAEPMR LSMDPPMPEL QGGQQEQELR QLLNKDKSKR SAVASSVVKQ KLAEVILKKQ
       130        140        150        160        170        180
QAALERTVHP SSPSIPYRTL EPLDTEGAAR SVLSSFLPPV PSLPTEPPEH FPLRKTVSEP
       190        200        210        220        230        240
NLKLRYKPKK SLERRKNPLL RKESAPPSLR RRPAETLGDS SPSSSSTPAS GCSSPNDSEH
       250        260        270        280        290        300
GPNPALGSEA DGDRRTHSTL GPRGPVLGNP HAPLFLHHGL EPEAGGTLPS RLQPILLLDP
       310        320        330        340        350        360
SVSHAPLWTV PGLGPLPFHF AQPLLTTERL SGSGLHRPLN RTRSEPLPPS ATASPLLAPL
       370        380        390        400        410        420
QPRQDRLKPH VQLIKPAISP PQRPAKPSEK PRLRQIPSAE DLETDGGGVG PMANDGLEHR
       430        440        450        460        470        480
ESGRGPPEGR GSISLQQHQQ VPPWEQQHLA GRLSQGSPGD SVLIPLAQVG HRPLSRTQSS
       490        500        510        520        530        540
PAAPVSLLSP EPTCQTQVLN SSETPATGLV YDSVMLKHQC SCGDNSKHPE HAGRIQSIWS
       550        560        570        580        590        600
RLQERGLRSQ CECLRGRKAS LEELQSVHSE RHVLLYGTNP LSRLKLDNGK LTGLLAQRTF
       610        620        630        640        650        660
VMLPCGGVGV DTDTIWNELH SSNAARWAAG SVTDLAFKVA SRELKNGFAV VRPPGHHADH
       670        680        690        700        710        720
STAMGFCFFN SVAIACRQLQ QHGKASKILI VDWDVHHGNG TQQTFYQDPS VLYISLHRHD
       730        740        750        760        770        780
DGNFFPGSGA VDEVGTGSGE GFNVNVAWAG GLDPPMGDPE YLAAFRIVVM PIAREFAPDL
       790        800        810        820        830        840
VLVSAGFDAA EGHPAPLGGY HVSAKCFGYM TQQLMNLAGG AVVLALEGGH DLTAICDASE
       850        860        870        880        890        900
ACVAALLGNK VDPLSEESWK QKPNLSAIRS LEAVVRVHRK YWGCMQRLAS CPDSWLPRVP
       910        920        930
GADAEVEAVT ALASLSVGIL AEDRPSERLV EEEEPMNL         10         20         30         40         50         60
MHSPGAGCPA LQPDTPGSQP QPMDLRVGQR PTVEPPPEPA LLTLQHPQRL HRHLFLAGLH
        70         80         90        100        110        120
QQQRSAEPMR LSMDPPMPEL QGGQQEQELR QLLNKDKSKR SAVASSVVKQ KLAEVILKKQ
       130        140        150        160        170        180
QAALERTVHP SSPSIPYRTL EPLDTEGAAR SVLSSFLPPV PSLPTEPPEH FPLRKTVSEP
       190        200        210        220        230        240
NLKLRYKPKK SLERRKNPLL RKESAPPSLR RRPAETLGDS SPSSSSTPAS GCSSPNDSEH
       250        260        270        280        290        300
GPNPALGSEA DGDRRTHSTL GPRGPVLGNP HAPLFLHHGL EPEAGGTLPS RLQPILLLDP
       310        320        330        340        350        360
SVSHAPLWTV PGLGPLPFHF AQPLLTTERL SGSGLHRPLN RTRSEPLPPS ATASPLLAPL
       370        380        390        400        410        420
QPRQDRLKPH VQLIKPAISP PQRPAKPSEK PRLRQIPSAE DLETDGGGVG PMANDGLEHR
       430        440        450        460        470        480
ESGRGPPEGR GSISLQQHQQ VPPWEQQHLA GRLSQGSPGD SVLIPLAQVG HRPLSRTQSS
       490        500        510        520        530        540
PAAPVSLLSP EPTCQTQVLN SSETPATGLV YDSVMLKHQC SCGDNSKHPE HAGRIQSIWS
       550        560        570        580        590        600
RLQERGLRSQ CECLRGRKAS LEELQSVHSE RHVLLYGTNP LSRLKLDNGK LTGLLAQRTF
       610        620        630        640        650        660
VMLPCGGVGV DTDTIWNELH SSNAARWAAG SVTDLAFKVA SRELKNGFAV VRPPGHHADH
       670        680        690        700        710        720
STAMGFCFFN SVAIACRQLQ QHGKASKILI VDWDVHHGNG TQQTFYQDPS VLYISLHRHD
       730        740        750        760        770        780
DGNFFPGSGA VDEVGTGSGE GFNVNVAWAG GLDPPMGDPE YLAAFRIVVM PIAREFAPDL
       790        800        810        820        830        840
VLVSAGFDAA EGHPAPLGGY HVSAKCFGYM TQQLMNLAGG AVVLALEGGH DLTAICDASE
       850        860        870        880        890        900
ACVAALLGNK VDPLSEESWK QKPNLSAIRS LEAVVRVHRK YWGCMQRLAS CPDSWLPRVP
       910        920        930
GADAEVEAVT ALASLSVGIL AEDRPSERLV EEEEPMNL         10         20         30         40         50         60
MHSPGAGCPA LQPDTPGSQP QPMDLRVGQR PTVEPPPEPA LLTLQHPQRL HRHLFLAGLH
        70         80         90        100        110        120
QQQRSAEPMR LSMDPPMPEL QGGQQEQELR QLLNKDKSKR SAVASSVVKQ KLAEVILKKQ
       130        140        150        160        170        180
QAALERTVHP SSPSIPYRTL EPLDTEGAAR SVLSSFLPPV PSLPTEPPEH FPLRKTVSEP
       190        200        210        220        230        240
NLKLRYKPKK SLERRKNPLL RKESAPPSLR RRPAETLGDS SPSSSSTPAS GCSSPNDSEH
       250        260        270        280        290        300
GPNPALGSEA DGDRRTHSTL GPRGPVLGNP HAPLFLHHGL EPEAGGTLPS RLQPILLLDP
       310        320        330        340        350        360
SVSHAPLWTV PGLGPLPFHF AQPLLTTERL SGSGLHRPLN RTRSEPLPPS ATASPLLAPL
       370        380        390        400        410        420
QPRQDRLKPH VQLIKPAISP PQRPAKPSEK PRLRQIPSAE DLETDGGGVG PMANDGLEHR
       430        440        450        460        470        480
ESGRGPPEGR GSISLQQHQQ VPPWEQQHLA GRLSQGSPGD SVLIPLAQVG HRPLSRTQSS
       490        500        510        520        530        540
PAAPVSLLSP EPTCQTQVLN SSETPATGLV YDSVMLKHQC SCGDNSKHPE HAGRIQSIWS
       550        560        570        580        590        600
RLQERGLRSQ CECLRGRKAS LEELQSVHSE RHVLLYGTNP LSRLKLDNGK LTGLLAQRTF
       610        620        630        640        650        660
VMLPCGGVGV DTDTIWNELH SSNAARWAAG SVTDLAFKVA SRELKNGFAV VRPPGHHADH
       670        680        690        700        710        720
STAMGFCFFN SVAIACRQLQ QHGKASKILI VDWDVHHGNG TQQTFYQDPS VLYISLHRHD
       730        740        750        760        770        780
DGNFFPGSGA VDEVGTGSGE GFNVNVAWAG GLDPPMGDPE YLAAFRIVVM PIAREFAPDL
       790        800        810        820        830        840
VLVSAGFDAA EGHPAPLGGY HVSAKCFGYM TQQLMNLAGG AVVLALEGGH DLTAICDASE
       850        860        870        880        890        900
ACVAALLGNK VDPLSEESWK QKPNLSAIRS LEAVVRVHRK YWGCMQRLAS CPDSWLPRVP
       910        920        930
GADAEVEAVT ALASLSVGIL AEDRPSERLV EEEEPMNL         10         20         30         40         50         60
MHSPGAGCPA LQPDTPGSQP QPMDLRVGQR PTVEPPPEPA LLTLQHPQRL HRHLFLAGLH
        70         80         90        100        110        120
QQQRSAEPMR LSMDPPMPEL QGGQQEQELR QLLNKDKSKR SAVASSVVKQ KLAEVILKKQ
       130        140        150        160        170        180
QAALERTVHP SSPSIPYRTL EPLDTEGAAR SVLSSFLPPV PSLPTEPPEH FPLRKTVSEP
       190        200        210        220        230        240
NLKLRYKPKK SLERRKNPLL RKESAPPSLR RRPAETLGDS SPSSSSTPAS GCSSPNDSEH
       250        260        270        280        290        300
GPNPALGSEA DGDRRTHSTL GPRGPVLGNP HAPLFLHHGL EPEAGGTLPS RLQPILLLDP
       310        320        330        340        350        360
SVSHAPLWTV PGLGPLPFHF AQPLLTTERL SGSGLHRPLN RTRSEPLPPS ATASPLLAPL
       370        380        390        400        410        420
QPRQDRLKPH VQLIKPAISP PQRPAKPSEK PRLRQIPSAE DLETDGGGVG PMANDGLEHR
       430        440        450        460        470        480
ESGRGPPEGR GSISLQQHQQ VPPWEQQHLA GRLSQGSPGD SVLIPLAQVG HRPLSRTQSS
       490        500        510        520        530        540
PAAPVSLLSP EPTCQTQVLN SSETPATGLV YDSVMLKHQC SCGDNSKHPE HAGRIQSIWS
       550        560        570        580        590        600
RLQERGLRSQ CECLRGRKAS LEELQSVHSE RHVLLYGTNP LSRLKLDNGK LTGLLAQRTF
       610        620        630        640        650        660
VMLPCGGVGV DTDTIWNELH SSNAARWAAG SVTDLAFKVA SRELKNGFAV VRPPGHHADH
       670        680        690        700        710        720
STAMGFCFFN SVAIACRQLQ QHGKASKILI VDWDVHHGNG TQQTFYQDPS VLYISLHRHD
       730        740        750        760        770        780
DGNFFPGSGA VDEVGTGSGE GFNVNVAWAG GLDPPMGDPE YLAAFRIVVM PIAREFAPDL
       790        800        810        820        830        840
VLVSAGFDAA EGHPAPLGGY HVSAKCFGYM TQQLMNLAGG AVVLALEGGH DLTAICDASE
       850        860        870        880        890        900
ACVAALLGNK VDPLSEESWK QKPNLSAIRS LEAVVRVHRK YWGCMQRLAS CPDSWLPRVP
       910        920        930
GADAEVEAVT ALASLSVGIL AEDRPSERLV EEEEPMNL         10         20         30         40         50         60
MHSPGAGCPA LQPDTPGSQP QPMDLRVGQR PTVEPPPEPA LLTLQHPQRL HRHLFLAGLH
        70         80         90        100        110        120
QQQRSAEPMR LSMDPPMPEL QGGQQEQELR QLLNKDKSKR SAVASSVVKQ KLAEVILKKQ
       130        140        150        160        170        180
QAALERTVHP SSPSIPYRTL EPLDTEGAAR SVLSSFLPPV PSLPTEPPEH FPLRKTVSEP
       190        200        210        220        230        240
NLKLRYKPKK SLERRKNPLL RKESAPPSLR RRPAETLGDS SPSSSSTPAS GCSSPNDSEH
       250        260        270        280        290        300
GPNPALGSEA DGDRRTHSTL GPRGPVLGNP HAPLFLHHGL EPEAGGTLPS RLQPILLLDP
       310        320        330        340        350        360
SVSHAPLWTV PGLGPLPFHF AQPLLTTERL SGSGLHRPLN RTRSEPLPPS ATASPLLAPL
       370        380        390        400        410        420
QPRQDRLKPH VQLIKPAISP PQRPAKPSEK PRLRQIPSAE DLETDGGGVG PMANDGLEHR
       430        440        450        460        470        480
ESGRGPPEGR GSISLQQHQQ VPPWEQQHLA GRLSQGSPGD SVLIPLAQVG HRPLSRTQSS
       490        500        510        520        530        540
PAAPVSLLSP EPTCQTQVLN SSETPATGLV YDSVMLKHQC SCGDNSKHPE HAGRIQSIWS
       550        560        570        580        590        600
RLQERGLRSQ CECLRGRKAS LEELQSVHSE RHVLLYGTNP LSRLKLDNGK LTGLLAQRTF
       610        620        630        640        650        660
VMLPCGGVGV DTDTIWNELH SSNAARWAAG SVTDLAFKVA SRELKNGFAV VRPPGHHADH
       670        680        690        700        710        720
STAMGFCFFN SVAIACRQLQ QHGKASKILI VDWDVHHGNG TQQTFYQDPS VLYISLHRHD
       730        740        750        760        770        780
DGNFFPGSGA VDEVGTGSGE GFNVNVAWAG GLDPPMGDPE YLAAFRIVVM PIAREFAPDL
       790        800        810        820        830        840
VLVSAGFDAA EGHPAPLGGY HVSAKCFGYM TQQLMNLAGG AVVLALEGGH DLTAICDASE
       850        860        870        880        890        900
ACVAALLGNK VDPLSEESWK QKPNLSAIRS LEAVVRVHRK YWGCMQRLAS CPDSWLPRVP
       910        920        930
GADAEVEAVT ALASLSVGIL AEDRPSERLV EEEEPMNL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8C2B3-1-unknown	MHSPGA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8C2B3-1-unknown	MHSPGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76816
Q8C2B3-1-unknown	MHSPGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76818
Q8C2B3-23-unknown	MDLRVG...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76814
Q8C2B3-23-unknown	MDLRVG...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76815
Q8C2B3-23-unknown	MDLRVG...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76817
Q8C2B3-23-unknown	MDLRVG...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt96624
Q8C2B3-23-unknown	MDLRVG...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt96625
Q8C2B3-406-unknown	GGGVGP...	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28610
Q8C2B3-406-unknown	GGGVGP...	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151678
Q8C2B3-406-unknown	GGGVGP...	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151721
Q8C2B3-406-unknown	GGGVGP...	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152196
Q8C2B3-406-unknown	GGGVGP...	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152235
Q8C2B3-406-unknown	GGGVGP...	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152356

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DLETDG	405	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28610
...DLETDG	405	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135081
...DLETDG	405	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135125
...DLETDG	405	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135606
...DLETDG	405	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135645
...DLETDG	405	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135767
...EPMNL	938	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EPMNL	938	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72436
...EPMNL	938	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72435
...EPMNL	938	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72434
...EPMNL	938	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72432
...EPMNL	938	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72433

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_MOUSE	405	ETDG.\|.GGGV	inferred from experiment	unknown	MEROPS	Salvesen GS	Scott FL et al.:Caspase-8 cleaves histone deace... (C14.009)	18458084,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)