Q8IUE6: Histone H2A type 2-B

General Information

Protein names	- Histone H2A type 2-B
Gene names	HIST2H2AB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IUE6

7 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGRGKQGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT
        70         80         90        100        110        120
AEILELAGNA ARDNKKTRII PRHLQLAVRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK
       130
TESHKPGKNK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IUE6-2-unknown	MSGRGK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IUE6-2-Acetylation	SGRGKQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IUE6-22-unknown	AGLQFP...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10414
Q8IUE6-60-unknown	TAEILE...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14698
Q8IUE6-60-unknown	TAEILE...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10415
Q8IUE6-61-unknown	AEILEL...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10416
Q8IUE6-83-	HLQLAV...	83			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8IUE6-106-	GGVLPN...	106			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRSSRA	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10414
...VLEYLT	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14698
...VLEYLT	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10415
...LEYLTA	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10416
...PGKNK	130	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	21	SSRA.\|.AGLQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	59	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	59	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	60	YLTA.\|.AEIL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)