Q8IWS0: PHD finger protein 6

General Information

Protein names	- PHD finger protein 6 - PHD-like zinc finger protein
Gene names	PHF6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IWS0

10 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of PHD finger protein 6 - Isoform 3 of PHD finger protein 6 - Isoform 4 of PHD finger protein 6 - Isoform 5 of PHD finger protein 6

Sequence View

        10         20         30         40         50         60
MSSSVEQKKG PTRQRKCGFC KSNRDKECGQ LLISENQKVA AHHKCMLFSS ALVSSHSDNE
        70         80         90        100        110        120
SLGGFSIEDV QKEIKRGTKL MCSLCHCPGA TIGCDVKTCH RTYHYHCALH DKAQIREKPS
       130        140        150        160        170        180
QGIYMVYCRK HKKTAHNSEA DLEESFNEHE LEPSSPKSKK KSRKGRPRKT NFKGLSEDTR
       190        200        210        220        230        240
STSSHGTDEM ESSSYRDRSP HRSSPSDTRP KCGFCHVGEE ENEARGKLHI FNAKKAAAHY
       250        260        270        280        290        300
KCMLFSSGTV QLTTTSRAEF GDFDIKTVLQ EIKRGKRMKC TLCSQPGATI GCEIKACVKT
       310        320        330        340        350        360
YHYHCGVQDK AKYIENMSRG IYKLYCKNHS GNDERDEEDE ERESKSRGKV EIDQQQLTQQ

QLNGN         10         20         30         40         50         60
MSSSVEQKKG PTRQRKCGFC KSNRDKECGQ LLISENQKVA AHHKCMLFSS ALVSSHSDNE
        70         80         90        100        110        120
SLGGFSIEDV QKEIKRGTKL MCSLCHCPGA TIGCDVKTCH RTYHYHCALH DKAQIREKPS
       130        140        150        160        170        180
QGIYMVYCRK HKKTAHNSEA DLEESFNEHE LEPSSPKSKK KSRKGRPRKT NFKGLSEDTR
       190        200        210        220        230        240
STSSHGTDEM ESSSYRDRSP HRSSPSDTRP KCGFCHVGEE ENEARGKLHI FNAKKAAAHY
       250        260        270        280        290        300
KCMLFSSGTV QLTTTSRAEF GDFDIKTVLQ EIKRGKRMKC TLCSQPGATI GCEIKACVKT
       310        320        330        340        350        360
YHYHCGVQDK AKYIENMSRG IYKLYCKNHS GNDERDEEDE ERESKSRGKV EIDQQQLTQQ

QLNGN         10         20         30         40         50         60
MSSSVEQKKG PTRQRKCGFC KSNRDKECGQ LLISENQKVA AHHKCMLFSS ALVSSHSDNE
        70         80         90        100        110        120
SLGGFSIEDV QKEIKRGTKL MCSLCHCPGA TIGCDVKTCH RTYHYHCALH DKAQIREKPS
       130        140        150        160        170        180
QGIYMVYCRK HKKTAHNSEA DLEESFNEHE LEPSSPKSKK KSRKGRPRKT NFKGLSEDTR
       190        200        210        220        230        240
STSSHGTDEM ESSSYRDRSP HRSSPSDTRP KCGFCHVGEE ENEARGKLHI FNAKKAAAHY
       250        260        270        280        290        300
KCMLFSSGTV QLTTTSRAEF GDFDIKTVLQ EIKRGKRMKC TLCSQPGATI GCEIKACVKT
       310        320        330        340        350        360
YHYHCGVQDK AKYIENMSRG IYKLYCKNHS GNDERDEEDE ERESKSRGKV EIDQQQLTQQ

QLNGN         10         20         30         40         50         60
MSSSVEQKKG PTRQRKCGFC KSNRDKECGQ LLISENQKVA AHHKCMLFSS ALVSSHSDNE
        70         80         90        100        110        120
SLGGFSIEDV QKEIKRGTKL MCSLCHCPGA TIGCDVKTCH RTYHYHCALH DKAQIREKPS
       130        140        150        160        170        180
QGIYMVYCRK HKKTAHNSEA DLEESFNEHE LEPSSPKSKK KSRKGRPRKT NFKGLSEDTR
       190        200        210        220        230        240
STSSHGTDEM ESSSYRDRSP HRSSPSDTRP KCGFCHVGEE ENEARGKLHI FNAKKAAAHY
       250        260        270        280        290        300
KCMLFSSGTV QLTTTSRAEF GDFDIKTVLQ EIKRGKRMKC TLCSQPGATI GCEIKACVKT
       310        320        330        340        350        360
YHYHCGVQDK AKYIENMSRG IYKLYCKNHS GNDERDEEDE ERESKSRGKV EIDQQQLTQQ

QLNGN

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IWS0-2-unknown	MSSSVE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IWS0-1-unknown	MSSSVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85062
Q8IWS0-1-unknown	MSSSVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85063
Q8IWS0-1-unknown	MSSSVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85064
Q8IWS0-1-unknown	MSSSVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85065
Q8IWS0-2-Acetylation	SSSVEQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IWS0-2-Acetylation	SSSVEQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8IWS0-2-Acetylation	SSSVEQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8IWS0-2-Acetylation	SSSVEQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110484
Q8IWS0-2-Acetylation	SSSVEQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110485
Q8IWS0-2-Acetylation	SSSVEQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110486
Q8IWS0-2-Acetylation	SSSVEQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110487
Q8IWS0-48-unknown	FSSALV...	48		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14704
Q8IWS0-48-unknown	FSSALV...	48		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139004
Q8IWS0-48-unknown	FSSALV...	48		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139006
Q8IWS0-48-unknown	FSSALV...	48		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139007
Q8IWS0-49-unknown	SSALVS...	49		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169707
Q8IWS0-49-unknown	SSALVS...	49		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169708
Q8IWS0-49-unknown	SSALVS...	49		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169709
Q8IWS0-49-	SSALVS...	49			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8IWS0-53-unknown	VSSHSD...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14708
Q8IWS0-53-unknown	VSSHSD...	53		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139392
Q8IWS0-53-unknown	VSSHSD...	53		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139395
Q8IWS0-53-unknown	VSSHSD...	53		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139396
Q8IWS0-181-	STSSHG...	181			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8IWS0-181-unknown	STSSHG...	181		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169702
Q8IWS0-181-unknown	STSSHG...	181		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169703
Q8IWS0-181-unknown	STSSHG...	181		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169704
Q8IWS0-181-unknown	STSSHG...	181		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169705
Q8IWS0-189-unknown	EMESSS...	189		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12789
Q8IWS0-189-unknown	EMESSS...	189		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144963
Q8IWS0-189-unknown	EMESSS...	189		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146201
Q8IWS0-189-unknown	EMESSS...	189		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146202
Q8IWS0-189-unknown	EMESSS...	189		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146268

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...HKCMLF	47	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14704
...HKCMLF	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122073
...HKCMLF	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122075
...HKCMLF	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122076
...FSSALV	52	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14708
...FSSALV	52	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122473
...FSSALV	52	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122476
...FSSALV	52	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122477
...SHGTDE	188	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12789
...SHGTDE	188	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128240
...SHGTDE	188	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129503
...SHGTDE	188	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129504
...SHGTDE	188	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129572
...RGIYKL	323	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000359835
...QLNGN	365		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QLNGN	365	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QLNGN	365	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt80683
...QLNGN	365	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt80681
...QLNGN	365		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	47	CMLF.\|.FSSA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	52	SALV.\|.VSSH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	188	GTDE.\|.EMES	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)