Q8IX12: Cell division cycle and apoptosis regulator protein 1

General Information

Protein names	- Cell division cycle and apoptosis regulator protein 1 - Cell cycle and apoptosis regulatory protein 1 - CARP-1 - Death inducer with SAP domain
Gene names	CCAR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IX12

9 N-termini

9 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA AGLTTQTPAN
        70         80         90        100        110        120
YQLTQTAALQ QQAAAAAAAL QQQYSQPQQA LYSVQQQLQQ PQQTLLTQPA VALPTSLSLS
       130        140        150        160        170        180
TPQPTAQITV SYPTPRSSQQ QTQPQKQRVF TGVVTKLHDT FGFVDEDVFF QLSAVKGKTP
       190        200        210        220        230        240
QVGDRVLVEA TYNPNMPFKW NAQRIQTLPN QNQSQTQPLL KTPPAVLQPI APQTTFGVQT
       250        260        270        280        290        300
QPQPQSLLQA QISAASITPL LQTQPQPLLQ QPQQKAGLLQ PPVRIVSQPQ PARRLDPPSR
       310        320        330        340        350        360
FSGRNDRGDQ VPNRKDDRSR ERERERRRSR ERSPQRKRSR ERSPRRERER SPRRVRRVVP
       370        380        390        400        410        420
RYTVQFSKFS LDCPSCDMME LRRRYQNLYI PSDFFDAQFT WVDAFPLSRP FQLGNYCNFY
       430        440        450        460        470        480
VMHREVESLE KNMAILDPPD ADHLYSAKVM LMASPSMEDL YHKSCALAED PQELRDGFQH
       490        500        510        520        530        540
PARLVKFLVG MKGKDEAMAI GGHWSPSLDG PDPEKDPSVL IKTAIRCCKA LTGIDLSVCT
       550        560        570        580        590        600
QWYRFAEIRY HRPEETHKGR TVPAHVETVV LFFPDVWHCL PTRSEWETLS RGYKQQLVEK
       610        620        630        640        650        660
LQGERKEADG EQDEEEKDDG EAKEISTPTH WSKLDPKTMK VNDLRKELES RALSSKGLKS
       670        680        690        700        710        720
QLIARLTKQL KVEEQKEEQK ELEKSEKEED EDDDRKSEDD KEEEERKRQE EIERQRRERR
       730        740        750        760        770        780
YILPDEPAII VHPNWAAKSG KFDCSIMSLS VLLDYRLEDN KEHSFEVSLF AELFNEMLQR
       790        800        810        820        830        840
DFGVRIYKSL LSLPEKEDKK EKDKKSKKDE RKDKKEERDD ETDEPKPKRR KSGDDKDKKE
       850        860        870        880        890        900
DRDERKKEDK RKDDSKDDDE TEEDNNQDEY DPMEAEEAED EEDDRDEEEM TKRDDKRDIN
       910        920        930        940        950        960
RYCKERPSKD KEKEKTQMIT INRDLLMAFV YFDQSHCGYL LEKDLEEILY TLGLHLSRAQ
       970        980        990       1000       1010       1020
VKKLLNKVVL RESCFYRKLT DTSKDEENHE ESESLQEDML GNRLLLPTPT VKQESKDVEE
      1030       1040       1050       1060       1070       1080
NVGLIVYNGA MVDVGSLLQK LEKSEKVRAE VEQKLQLLEE KTDEDEKTIL NLENSNKSLS
      1090       1100       1110       1120       1130       1140
GELREVKKDL SQLQENLKIS ENMNLQFENQ MNKTIRNLST VMDEIHTVLK KDNVKNEDKD
      1150
QKSKENGASV

Isoforms

- Isoform 2 of Cell division cycle and apoptosis regulator protein 1

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 9 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IX12-1-unknown	MAQFGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IX12-1-unknown	MAQFGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69641
Q8IX12-118-unknown	SLSTPQ...	118	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174255
Q8IX12-118-	SLSTPQ...	118		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IX12-196-unknown	MPFKWN...	196	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439642
Q8IX12-196-unknown	MPFKWN...	196	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198018
Q8IX12-256-	SITPLL...	256		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IX12-256-unknown	SITPLL...	256	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171586
Q8IX12-262-unknown	QTQPQP...	262	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168300
Q8IX12-262-	QTQPQP...	262		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8IX12-269-unknown	LQQPQQ...	269	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14724
Q8IX12-269-unknown	LQQPQQ...	269	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148591

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PSLLGA	36	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000443808
...PSLLGA	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153780
...TSLSLS	119	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438881
...TSLSLS	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154563
...DVFFQL	171	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442410
...DVFFQL	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155277
...QPQPLL	268	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14724
...QPQPLL	268	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131965
...PEKEDK	798	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438610
...DKKEDR	841	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439642
...QEDMLG	1000	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438939
...KLQLLE	1058	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439252
...NGASV	1150	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NGASV	1150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65259

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	268	QPLL.\|.LQQP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)