Q8IZ21: Phosphatase and actin regulator 4

General Information

Protein names	- Phosphatase and actin regulator 4
Gene names	PHACTR4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IZ21

11 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Phosphatase and actin regulator 4 - Isoform 3 of Phosphatase and actin regulator 4 - Isoform 4 of Phosphatase and actin regulator 4

Sequence View

        10         20         30         40         50         60
MEDPFEEADQ PTTEPGMVLD SVEAGDTTPP TKRKSKFSGF GKIFKPWKWR KKKSSDKFKE
        70         80         90        100        110        120
TSEVLERKIS MRKPREELVK RGVLLEDPEQ GGEDPGKPSD AMLKNGHTTP IGNARSSSPV
       130        140        150        160        170        180
QVEEEPVRLA SLRKAIPEED LKKRLGSTGS QPNSEAESVP ENVPKPPLLP PKRPLSSSHE
       190        200        210        220        230        240
ASEGQAKDAT SSGGTARFII STSITTAPAA TTAATSLAKT VNLSVTPSPA PRTLPAAPAS
       250        260        270        280        290        300
TNTTATPSLT HMVPAKQPPI PPPKPAHRNS NPVIAELSQA INSGTLLSKP SPPLPPKRGI
       310        320        330        340        350        360
PSTSVPTLES AAAITTKTPS DEREKSTCSM GSELLPMISP RSPSPPLPTH IPPEPPRTPP
       370        380        390        400        410        420
FPAKTFQVVP EIEFPPSLDL HQEIPQQEDQ KKEVPKRILD QNFGEPHIPS RLPPLPLHIR
       430        440        450        460        470        480
IQQALTSPLP MTPILEGSHR AHSLLFENSD SFSEDSSTLG RTRSLPITIE MLKVPDDEEE
       490        500        510        520        530        540
EEQTCPSTFS EEMTPTSVIP KLPQCLREEE EKESDSDSEG PIQYRDEEDE DESYQSALAN
       550        560        570        580        590        600
KVKRKDTLAM KLNHRPSEPE LNLNSWPCKS KEEWNEIRHQ IGNTLIRRLS QRPTPEELEQ
       610        620        630        640        650        660
RNILQPKNEA DRQAEKREIK RRLTRKLSQR PTVAELLARK ILRFNEYVEV TDAQDYDRRA
       670        680        690        700
DKPWTKLTPA DKAAIRKELN EFKSSEMEVH EESKHFTRYH RP         10         20         30         40         50         60
MEDPFEEADQ PTTEPGMVLD SVEAGDTTPP TKRKSKFSGF GKIFKPWKWR KKKSSDKFKE
        70         80         90        100        110        120
TSEVLERKIS MRKPREELVK RGVLLEDPEQ GGEDPGKPSD AMLKNGHTTP IGNARSSSPV
       130        140        150        160        170        180
QVEEEPVRLA SLRKAIPEED LKKRLGSTGS QPNSEAESVP ENVPKPPLLP PKRPLSSSHE
       190        200        210        220        230        240
ASEGQAKDAT SSGGTARFII STSITTAPAA TTAATSLAKT VNLSVTPSPA PRTLPAAPAS
       250        260        270        280        290        300
TNTTATPSLT HMVPAKQPPI PPPKPAHRNS NPVIAELSQA INSGTLLSKP SPPLPPKRGI
       310        320        330        340        350        360
PSTSVPTLES AAAITTKTPS DEREKSTCSM GSELLPMISP RSPSPPLPTH IPPEPPRTPP
       370        380        390        400        410        420
FPAKTFQVVP EIEFPPSLDL HQEIPQQEDQ KKEVPKRILD QNFGEPHIPS RLPPLPLHIR
       430        440        450        460        470        480
IQQALTSPLP MTPILEGSHR AHSLLFENSD SFSEDSSTLG RTRSLPITIE MLKVPDDEEE
       490        500        510        520        530        540
EEQTCPSTFS EEMTPTSVIP KLPQCLREEE EKESDSDSEG PIQYRDEEDE DESYQSALAN
       550        560        570        580        590        600
KVKRKDTLAM KLNHRPSEPE LNLNSWPCKS KEEWNEIRHQ IGNTLIRRLS QRPTPEELEQ
       610        620        630        640        650        660
RNILQPKNEA DRQAEKREIK RRLTRKLSQR PTVAELLARK ILRFNEYVEV TDAQDYDRRA
       670        680        690        700
DKPWTKLTPA DKAAIRKELN EFKSSEMEVH EESKHFTRYH RP         10         20         30         40         50         60
MEDPFEEADQ PTTEPGMVLD SVEAGDTTPP TKRKSKFSGF GKIFKPWKWR KKKSSDKFKE
        70         80         90        100        110        120
TSEVLERKIS MRKPREELVK RGVLLEDPEQ GGEDPGKPSD AMLKNGHTTP IGNARSSSPV
       130        140        150        160        170        180
QVEEEPVRLA SLRKAIPEED LKKRLGSTGS QPNSEAESVP ENVPKPPLLP PKRPLSSSHE
       190        200        210        220        230        240
ASEGQAKDAT SSGGTARFII STSITTAPAA TTAATSLAKT VNLSVTPSPA PRTLPAAPAS
       250        260        270        280        290        300
TNTTATPSLT HMVPAKQPPI PPPKPAHRNS NPVIAELSQA INSGTLLSKP SPPLPPKRGI
       310        320        330        340        350        360
PSTSVPTLES AAAITTKTPS DEREKSTCSM GSELLPMISP RSPSPPLPTH IPPEPPRTPP
       370        380        390        400        410        420
FPAKTFQVVP EIEFPPSLDL HQEIPQQEDQ KKEVPKRILD QNFGEPHIPS RLPPLPLHIR
       430        440        450        460        470        480
IQQALTSPLP MTPILEGSHR AHSLLFENSD SFSEDSSTLG RTRSLPITIE MLKVPDDEEE
       490        500        510        520        530        540
EEQTCPSTFS EEMTPTSVIP KLPQCLREEE EKESDSDSEG PIQYRDEEDE DESYQSALAN
       550        560        570        580        590        600
KVKRKDTLAM KLNHRPSEPE LNLNSWPCKS KEEWNEIRHQ IGNTLIRRLS QRPTPEELEQ
       610        620        630        640        650        660
RNILQPKNEA DRQAEKREIK RRLTRKLSQR PTVAELLARK ILRFNEYVEV TDAQDYDRRA
       670        680        690        700
DKPWTKLTPA DKAAIRKELN EFKSSEMEVH EESKHFTRYH RP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IZ21-1-unknown	MEDPFE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IZ21-17-unknown	MVLDSV...	17	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85018
Q8IZ21-17-unknown	MVLDSV...	17	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97372
Q8IZ21-18-unknown	VLDSVE...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169471
Q8IZ21-18-unknown	VLDSVE...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169472
Q8IZ21-18-	VLDSVE...	18		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8IZ21-21-unknown	SVEAGD...	21		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8IZ21-21-unknown	SVEAGD...	21	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161927
Q8IZ21-21-unknown	SVEAGD...	21	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161928
Q8IZ21-21-	SVEAGD...	21		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8IZ21-21-	SVEAGD...	21		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8IZ21-21-	SVEAGD...	21		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IZ21-21-	SVEAGD...	21		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8IZ21-21-	SVEAGD...	21		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8IZ21-176-unknown	SSSHEA...	176	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14732
Q8IZ21-176-unknown	SSSHEA...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145142
Q8IZ21-176-unknown	SSSHEA...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146109
Q8IZ21-310-	SAAAIT...	310		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8IZ21-310-unknown	SAAAIT...	310	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177803
Q8IZ21-310-unknown	SAAAIT...	310	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177804
Q8IZ21-451-unknown	SFSEDS...	451	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177800
Q8IZ21-451-unknown	SFSEDS...	451	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177801
Q8IZ21-451-	SFSEDS...	451		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PKRPLS	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14732
...PKRPLS	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128429
...PKRPLS	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129409
...RYHRP	702	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RYHRP	702	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80636
...RYHRP	702	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80635

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	175	RPLS.\|.SSSH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)