Q8IZL8: Proline-, glutamic acid- and leucine-rich protein 1
Protein names | - Proline-, glutamic acid- and leucine-rich protein 1 - Modulator of non-genomic activity of estrogen receptor - Transcription factor HMX3 |
---|---|
Gene names | PELP1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q8IZL8 |
7
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG SAVAPVHPPN
70 80 90 100 110 120
RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS SIKTRFEGLC LLSLLVGESP
130 140 150 160 170 180
TELFQQHCVS WLRSIQQVLQ TQDPPATMEL AVAVLRDLLR YAAQLPALFR DISMNHLPGL
190 200 210 220 230 240
LTSLLGLRPE CEQSALEGMK ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY
250 260 270 280 290 300
SRLPSLGAGF SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS
310 320 330 340 350 360
EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS VSSKNISLHG
370 380 390 400 410 420
DGPLRLLLLP SIHLEALDLL SALILACGSR LLRFGILIGR LLPQVLNSWS IGRDSLSPGQ
430 440 450 460 470 480
ERPYSTVRTK VYAILELWVQ VCGASAGMLQ GGASGEALLT HLLSDISPPA DALKLRSPRG
490 500 510 520 530 540
SPDGSLQTGK PSAPKKLKLD VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI
550 560 570 580 590 600
KEETHRRLHD LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC
610 620 630 640 650 660
ALQAFSLGQR EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP VPPPEAPSPF
670 680 690 700 710 720
RAPPFHPPGP MPSVGSMPSA GPMPSAGPMP SAGPVPSARP GPPTTANHLG LSVPGLVSVP
730 740 750 760 770 780
PRLLPGPENH RAGSNEDPIL APSGTPPPTI PPDETFGGRV PRPAFVHYDK EEASDVEISL
790 800 810 820 830 840
ESDSDDSVVI VPEGLPPLPP PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP
850 860 870 880 890 900
PPPPPPPPVP GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE
910 920 930 940 950 960
EEEEEEEEDF EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED EEEEEELEEV
970 980 990 1000 1010 1020
EDLEFGTAGG EVEEGAPPPP TLPPALPPPE SPPKVQPEPE PEPGLLLEVE EPGTEEERGA
1030 1040 1050 1060 1070 1080
DTAPTLAPEA LPSQGEVERE GESPAAGPPP QELVEEEPSA PPTLLEEETE DGSDKVQPPP
1090 1100 1110 1120 1130
ETPAEEEMET ETEAEALQEK EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS
Isoforms
- Isoform 2 of Proline-, glutamic acid- and leucine-rich protein 1Sequence View
10 20 30 40 50 60
MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG SAVAPVHPPN
70 80 90 100 110 120
RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS SIKTRFEGLC LLSLLVGESP
130 140 150 160 170 180
TELFQQHCVS WLRSIQQVLQ TQDPPATMEL AVAVLRDLLR YAAQLPALFR DISMNHLPGL
190 200 210 220 230 240
LTSLLGLRPE CEQSALEGMK ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY
250 260 270 280 290 300
SRLPSLGAGF SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS
310 320 330 340 350 360
EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS VSSKNISLHG
370 380 390 400 410 420
DGPLRLLLLP SIHLEALDLL SALILACGSR LLRFGILIGR LLPQVLNSWS IGRDSLSPGQ
430 440 450 460 470 480
ERPYSTVRTK VYAILELWVQ VCGASAGMLQ GGASGEALLT HLLSDISPPA DALKLRSPRG
490 500 510 520 530 540
SPDGSLQTGK PSAPKKLKLD VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI
550 560 570 580 590 600
KEETHRRLHD LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC
610 620 630 640 650 660
ALQAFSLGQR EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP VPPPEAPSPF
670 680 690 700 710 720
RAPPFHPPGP MPSVGSMPSA GPMPSAGPMP SAGPVPSARP GPPTTANHLG LSVPGLVSVP
730 740 750 760 770 780
PRLLPGPENH RAGSNEDPIL APSGTPPPTI PPDETFGGRV PRPAFVHYDK EEASDVEISL
790 800 810 820 830 840
ESDSDDSVVI VPEGLPPLPP PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP
850 860 870 880 890 900
PPPPPPPPVP GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE
910 920 930 940 950 960
EEEEEEEEDF EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED EEEEEELEEV
970 980 990 1000 1010 1020
EDLEFGTAGG EVEEGAPPPP TLPPALPPPE SPPKVQPEPE PEPGLLLEVE EPGTEEERGA
1030 1040 1050 1060 1070 1080
DTAPTLAPEA LPSQGEVERE GESPAAGPPP QELVEEEPSA PPTLLEEETE DGSDKVQPPP
1090 1100 1110 1120 1130
ETPAEEEMET ETEAEALQEK EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS
Protein Neighborhood
Domains & Features
7 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q8IZL8-2-unknown | MAAAVL... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q8IZL8-1-unknown | MAAAVL... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt84858 | |||
Q8IZL8-2-Acetylation | AAAVLS... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q8IZL8-2-Acetylation | AAAVLS... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q8IZL8-2-Acetylation | AAAVLS... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
Q8IZL8-2-Acetylation | AAAVLS... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q8IZL8-2-Acetylation | AAAVLS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111118 | ||
Q8IZL8-3-acetylation | AAVLSG... | 3 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
Q8IZL8-3-acetylation | AAVLSG... | 3 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt163344 | ||
Q8IZL8-7-unknown | SGPSAG... | 7 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14735 | |||
Q8IZL8-7-unknown | SGPSAG... | 7 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt194768 | |||
Q8IZL8-138-unknown | VLQTQD... | 138 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
Q8IZL8-138-unknown | VLQTQD... | 138 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197516 | |||
Q8IZL8-1030-unknown | ALPSQG... | 1030 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12839 | |||
Q8IZL8-1030-unknown | ALPSQG... | 1030 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157584 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AAAVLS | 6 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14735 | |||
...TLAPEA | 1029 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12839 | |||
...TLAPEA | 1029 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141083 | |||
...TEPDS | 1130 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...TEPDS | 1130 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt80476 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAM_HUMAN | 6 | AVLS.|.SGPS | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
GRAB_HUMAN | 1029 | APEA.|.ALPS | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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