Q8N465: D-2-hydroxyglutarate dehydrogenase, mitochondrial

General Information

Protein names	- D-2-hydroxyglutarate dehydrogenase, mitochondrial - 1.1.99.-
Gene names	D2HGDH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N465

7 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of D-2-hydroxyglutarate dehydrogenase, mitochondrial - Isoform 3 of D-2-hydroxyglutarate dehydrogenase, mitochondrial

Sequence View

        10         20         30         40         50         60
MLPRRPLAWP AWLLRGAPGA AGSWGRPVGP LARRGCCSAP GTPEVPLTRE RYPVRRLPFS
        70         80         90        100        110        120
TVSKQDLAAF ERIVPGGVVT DPEALQAPNV DWLRTLRGCS KVLLRPRTSE EVSHILRHCH
       130        140        150        160        170        180
ERNLAVNPQG GNTGMVGGSV PVFDEIILST ARMNRVLSFH SVSGILVCQA GCVLEELSRY
       190        200        210        220        230        240
VEERDFIMPL DLGAKGSCHI GGNVATNAGG LRFLRYGSLH GTVLGLEVVL ADGTVLDCLT
       250        260        270        280        290        300
SLRKDNTGYD LKQLFIGSEG TLGIITTVSI LCPPKPRAVN VAFLGCPGFA EVLQTFSTCK
       310        320        330        340        350        360
GMLGEILSAF EFMDAVCMQL VGRHLHLASP VQESPFYVLI ETSGSNAGHD AEKLGHFLEH
       370        380        390        400        410        420
ALGSGLVTDG TMATDQRKVK MLWALRERIT EALSRDGYVY KYDLSLPVER LYDIVTDLRA
       430        440        450        460        470        480
RLGPHAKHVV GYGHLGDGNL HLNVTAEAFS PSLLAALEPH VYEWTAGQQG SVSAEHGVGF
       490        500        510        520
RKRDVLGYSK PPGALQLMQQ LKALLDPKGI LNPYKTLPSQ A         10         20         30         40         50         60
MLPRRPLAWP AWLLRGAPGA AGSWGRPVGP LARRGCCSAP GTPEVPLTRE RYPVRRLPFS
        70         80         90        100        110        120
TVSKQDLAAF ERIVPGGVVT DPEALQAPNV DWLRTLRGCS KVLLRPRTSE EVSHILRHCH
       130        140        150        160        170        180
ERNLAVNPQG GNTGMVGGSV PVFDEIILST ARMNRVLSFH SVSGILVCQA GCVLEELSRY
       190        200        210        220        230        240
VEERDFIMPL DLGAKGSCHI GGNVATNAGG LRFLRYGSLH GTVLGLEVVL ADGTVLDCLT
       250        260        270        280        290        300
SLRKDNTGYD LKQLFIGSEG TLGIITTVSI LCPPKPRAVN VAFLGCPGFA EVLQTFSTCK
       310        320        330        340        350        360
GMLGEILSAF EFMDAVCMQL VGRHLHLASP VQESPFYVLI ETSGSNAGHD AEKLGHFLEH
       370        380        390        400        410        420
ALGSGLVTDG TMATDQRKVK MLWALRERIT EALSRDGYVY KYDLSLPVER LYDIVTDLRA
       430        440        450        460        470        480
RLGPHAKHVV GYGHLGDGNL HLNVTAEAFS PSLLAALEPH VYEWTAGQQG SVSAEHGVGF
       490        500        510        520
RKRDVLGYSK PPGALQLMQQ LKALLDPKGI LNPYKTLPSQ A

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N465-1-unknown	MLPRRP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72274
Q8N465-1-unknown	MLPRRP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72275
Q8N465-14-unknown	LRGAPG...	14	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N465-14-unknown	LRGAPG...	14	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111769
Q8N465-14-unknown	LRGAPG...	14	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111770
Q8N465-38-unknown	SAPGTP...	38		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8N465-38-unknown	SAPGTP...	38		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8N465-38-unknown	SAPGTP...	38	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159577
Q8N465-38-unknown	SAPGTP...	38	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159578
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8N465-38-	SAPGTP...	38		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8N465-117-unknown	RHCHER...	117	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412511
Q8N465-117-unknown	RHCHER...	117	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197197
Q8N465-117-unknown	RHCHER...	117	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197198
Q8N465-131-unknown	GNTGMV...	131	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404596
Q8N465-131-unknown	GNTGMV...	131	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197424
Q8N465-131-unknown	GNTGMV...	131	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197425
Q8N465-135-unknown	MVGGSV...	135	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000384723
Q8N465-135-unknown	MVGGSV...	135	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197464
Q8N465-135-unknown	MVGGSV...	135	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197465

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GRHLHL	326	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412511
...ATDQRK	377	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404596
...GYGHLG	435	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395837
...KTLPSQ	519	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387479
...LPSQA	521	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)