Q8N4P3: Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

General Information

Protein names	- Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 - 3.1.7.2 - HD domain-containing protein 3 - Metazoan SpoT homolog 1 - MESH1 - Penta-phosphate guanosine-3'-pyrophosphohydrolase - (ppGpp)ase
Gene names	HDDC3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N4P3

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGSEAAQLLE AADFAARKHR QQRRKDPEGT PYINHPIGVA RILTHEAGIT DIVVLQAALL
        70         80         90        100        110        120
HDTVEDTDTT LDEVELHFGA QVRRLVEEVT DDKTLPKLER KRLQVEQAPH SSPGAKLVKL
       130        140        150        160        170
ADKLYNLRDL NRCTPEGWSE HRVQEYFEWA AQVVKGLQGT NRQLEEALKH LFKQRGLTI

Isoforms

- Isoform 2 of Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N4P3-1-unknown	MGSEAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80912
Q8N4P3-2-unknown	MGSEAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N4P3-2-unknown	MGSEAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173976
Q8N4P3-2-Acetylation	GSEAAQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N4P3-2-Acetylation	GSEAAQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8N4P3-2-Acetylation	GSEAAQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8N4P3-2-Acetylation	GSEAAQ...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q8N4P3-2-Acetylation	GSEAAQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110898
Q8N4P3-2-	GSEAAQ...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...RGLTI	179	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)