Q8NBS9: Thioredoxin domain-containing protein 5
Protein names | - Thioredoxin domain-containing protein 5 - Endoplasmic reticulum resident protein 46 - ER protein 46 - ERp46 - Thioredoxin-like protein p46 |
---|---|
Gene names | TXNDC5 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q8NBS9 |
18
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPARPGRLLP LLARPAALTA LLLLLLGHGG GGRWGARAQE AAAAAADGPP AADGEDGQDP
70 80 90 100 110 120
HSKHLYTADM FTHGIQSAAH FVMFFAPWCG HCQRLQPTWN DLGDKYNSME DAKVYVAKVD
130 140 150 160 170 180
CTAHSDVCSA QGVRGYPTLK LFKPGQEAVK YQGPRDFQTL ENWMLQTLNE EPVTPEPEVE
190 200 210 220 230 240
PPSAPELKQG LYELSASNFE LHVAQGDHFI KFFAPWCGHC KALAPTWEQL ALGLEHSETV
250 260 270 280 290 300
KIGKVDCTQH YELCSGNQVR GYPTLLWFRD GKKVDQYKGK RDLESLREYV ESQLQRTETG
310 320 330 340 350 360
ATETVTPSEA PVLAAEPEAD KGTVLALTEN NFDDTIAEGI TFIKFYAPWC GHCKTLAPTW
370 380 390 400 410 420
EELSKKEFPG LAGVKIAEVD CTAERNICSK YSVRGYPTLL LFRGGKKVSE HSGGRDLDSL
430
HRFVLSQAKD EL
Isoforms
- Isoform 2 of Thioredoxin domain-containing protein 5Sequence View
10 20 30 40 50 60
MPARPGRLLP LLARPAALTA LLLLLLGHGG GGRWGARAQE AAAAAADGPP AADGEDGQDP
70 80 90 100 110 120
HSKHLYTADM FTHGIQSAAH FVMFFAPWCG HCQRLQPTWN DLGDKYNSME DAKVYVAKVD
130 140 150 160 170 180
CTAHSDVCSA QGVRGYPTLK LFKPGQEAVK YQGPRDFQTL ENWMLQTLNE EPVTPEPEVE
190 200 210 220 230 240
PPSAPELKQG LYELSASNFE LHVAQGDHFI KFFAPWCGHC KALAPTWEQL ALGLEHSETV
250 260 270 280 290 300
KIGKVDCTQH YELCSGNQVR GYPTLLWFRD GKKVDQYKGK RDLESLREYV ESQLQRTETG
310 320 330 340 350 360
ATETVTPSEA PVLAAEPEAD KGTVLALTEN NFDDTIAEGI TFIKFYAPWC GHCKTLAPTW
370 380 390 400 410 420
EELSKKEFPG LAGVKIAEVD CTAERNICSK YSVRGYPTLL LFRGGKKVSE HSGGRDLDSL
430
HRFVLSQAKD EL
Protein Neighborhood
Domains & Features
18 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q8NBS9-33-unknown | RWGARA... | 33 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q8NBS9-40- | EAAAAA... | 40 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q8NBS9-40- | EAAAAA... | 40 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q8NBS9-40- | EAAAAA... | 40 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q8NBS9-42- | AAAAAD... | 42 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q8NBS9-42- | AAAAAD... | 42 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q8NBS9-42- | AAAAAD... | 42 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q8NBS9-42- | AAAAAD... | 42 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q8NBS9-43- | AAAADG... | 43 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | RMPI_untreated | 23264352 | |||
Q8NBS9-44- | AAADGP... | 44 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q8NBS9-44-unknown | AAADGP... | 44 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q8NBS9-44-unknown | AAADGP... | 44 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q8NBS9-45- | AADGPP... | 45 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q8NBS9-45- | AADGPP... | 45 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q8NBS9-45- | AADGPP... | 45 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q8NBS9-45- | AADGPP... | 45 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q8NBS9-45- | AADGPP... | 45 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q8NBS9-45- | AADGPP... | 45 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q8NBS9-45- | AADGPP... | 45 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q8NBS9-45- | AADGPP... | 45 | Subtiligase Based Positive Selection | Wells | RMPI_untreated | 23264352 | |||
Q8NBS9-45- | AADGPP... | 45 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q8NBS9-45-unknown | AADGPP... | 45 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q8NBS9-45-unknown | AADGPP... | 45 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q8NBS9-46- | ADGPPA... | 46 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q8NBS9-46- | ADGPPA... | 46 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q8NBS9-109-unknown | MEDAKV... | 109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt93476 | |||
Q8NBS9-164- | MLQTLN... | 164 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q8NBS9-164-unknown | MLQTLN... | 164 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174643 | |||
Q8NBS9-315- | AEPEAD... | 315 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q8NBS9-315-unknown | AEPEAD... | 315 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177679 | |||
Q8NBS9-326- | ALTENN... | 326 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q8NBS9-326- | ALTENN... | 326 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q8NBS9-326-unknown | ALTENN... | 326 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174645 | |||
Q8NBS9-387-unknown | ICSKYS... | 387 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176709 | |||
Q8NBS9-387- | ICSKYS... | 387 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AKDEL | 432 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
...AKDEL | 432 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...AKDEL | 432 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89094 | |||
...AKDEL | 432 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...AKDEL | 432 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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