Q8TCY9: Up-regulator of cell proliferation

General Information

Protein names	- Up-regulator of cell proliferation - HBV X protein up-regulated gene 4 protein - HBxAg up-regulated gene 4 protein
Gene names	URGCP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TCY9

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Up-regulator of cell proliferation - Isoform 3 of Up-regulator of cell proliferation - Isoform 4 of Up-regulator of cell proliferation

Sequence View

        10         20         30         40         50         60
MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE FRYGDGTNEA
        70         80         90        100        110        120
QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF DSMKNWAPQV PKDLPWNFLR
       130        140        150        160        170        180
KLQALNADAR NTTMVLDVLP DARPVEKESQ MEEEIIYWDP ADDLAADIYS FSELPTPDTP
       190        200        210        220        230        240
VNPLDLLCAL LLSSDSFLQQ EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIVRTWW
       250        260        270        280        290        300
SQPPRGMGSF REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL
       310        320        330        340        350        360
GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL LTEISSAVFI
       370        380        390        400        410        420
LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF LNKLIPVLKI DHSHVLVKVS
       430        440        450        460        470        480
STDSDSFVKR IRAIVGNVLR APCRRVSVED MAHAARKLGL KVDEDCEECQ KAKDRMERIT
       490        500        510        520        530        540
RKIKDSDAYR RDELRLQGDP WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQN
       550        560        570        580        590        600
GHDPSSGVQE FISGISSPSL SEKQYFLRWM EWGLARVAQP RLRQPPETLL TLRPKHGGTT
       610        620        630        640        650        660
DVGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA SELLLTGLPL
       670        680        690        700        710        720
ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV PGTGKSTLLN TMFGLRFATG
       730        740        750        760        770        780
KSCGPRGAFM QLITVAEGFS QDLGCDHILV IDSGGLIGGA LTSAGDRFEL EASLATLLMG
       790        800        810        820        830        840
LSNVTVISLA ETKDIPAAIL HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD
       850        860        870        880        890        900
PPGDLSRAAA QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF
       910        920        930
ELKRCLLENI RNGLSNQNKN IQQLIELVRR L         10         20         30         40         50         60
MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE FRYGDGTNEA
        70         80         90        100        110        120
QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF DSMKNWAPQV PKDLPWNFLR
       130        140        150        160        170        180
KLQALNADAR NTTMVLDVLP DARPVEKESQ MEEEIIYWDP ADDLAADIYS FSELPTPDTP
       190        200        210        220        230        240
VNPLDLLCAL LLSSDSFLQQ EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIVRTWW
       250        260        270        280        290        300
SQPPRGMGSF REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL
       310        320        330        340        350        360
GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL LTEISSAVFI
       370        380        390        400        410        420
LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF LNKLIPVLKI DHSHVLVKVS
       430        440        450        460        470        480
STDSDSFVKR IRAIVGNVLR APCRRVSVED MAHAARKLGL KVDEDCEECQ KAKDRMERIT
       490        500        510        520        530        540
RKIKDSDAYR RDELRLQGDP WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQN
       550        560        570        580        590        600
GHDPSSGVQE FISGISSPSL SEKQYFLRWM EWGLARVAQP RLRQPPETLL TLRPKHGGTT
       610        620        630        640        650        660
DVGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA SELLLTGLPL
       670        680        690        700        710        720
ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV PGTGKSTLLN TMFGLRFATG
       730        740        750        760        770        780
KSCGPRGAFM QLITVAEGFS QDLGCDHILV IDSGGLIGGA LTSAGDRFEL EASLATLLMG
       790        800        810        820        830        840
LSNVTVISLA ETKDIPAAIL HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD
       850        860        870        880        890        900
PPGDLSRAAA QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF
       910        920        930
ELKRCLLENI RNGLSNQNKN IQQLIELVRR L         10         20         30         40         50         60
MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE FRYGDGTNEA
        70         80         90        100        110        120
QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF DSMKNWAPQV PKDLPWNFLR
       130        140        150        160        170        180
KLQALNADAR NTTMVLDVLP DARPVEKESQ MEEEIIYWDP ADDLAADIYS FSELPTPDTP
       190        200        210        220        230        240
VNPLDLLCAL LLSSDSFLQQ EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIVRTWW
       250        260        270        280        290        300
SQPPRGMGSF REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL
       310        320        330        340        350        360
GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL LTEISSAVFI
       370        380        390        400        410        420
LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF LNKLIPVLKI DHSHVLVKVS
       430        440        450        460        470        480
STDSDSFVKR IRAIVGNVLR APCRRVSVED MAHAARKLGL KVDEDCEECQ KAKDRMERIT
       490        500        510        520        530        540
RKIKDSDAYR RDELRLQGDP WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQN
       550        560        570        580        590        600
GHDPSSGVQE FISGISSPSL SEKQYFLRWM EWGLARVAQP RLRQPPETLL TLRPKHGGTT
       610        620        630        640        650        660
DVGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA SELLLTGLPL
       670        680        690        700        710        720
ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV PGTGKSTLLN TMFGLRFATG
       730        740        750        760        770        780
KSCGPRGAFM QLITVAEGFS QDLGCDHILV IDSGGLIGGA LTSAGDRFEL EASLATLLMG
       790        800        810        820        830        840
LSNVTVISLA ETKDIPAAIL HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD
       850        860        870        880        890        900
PPGDLSRAAA QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF
       910        920        930
ELKRCLLENI RNGLSNQNKN IQQLIELVRR L

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8TCY9-1-unknown	MASPGI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8TCY9-44-unknown	MEGDDC...	44	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93956
Q8TCY9-44-unknown	MEGDDC...	44	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt96032
Q8TCY9-53-unknown	YGDGTN...	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10442
Q8TCY9-53-unknown	YGDGTN...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138684
Q8TCY9-53-unknown	YGDGTN...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195980
Q8TCY9-76-unknown	MLSLLG...	76	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93955
Q8TCY9-76-unknown	MLSLLG...	76	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt95947
Q8TCY9-76-unknown	MLSLLG...	76	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt95948
Q8TCY9-695-unknown	LSTVGV...	695	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18056
Q8TCY9-695-unknown	LSTVGV...	695	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154919
Q8TCY9-695-unknown	LSTVGV...	695	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155342
Q8TCY9-695-unknown	LSTVGV...	695	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155715

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DCEFRY	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10442
...DCEFRY	52	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121738
...SRLVVL	694	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18056
...SRLVVL	694	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138346
...SRLVVL	694	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138775
...SRLVVL	694	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139161
...LVRRL	931	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LVRRL	931	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89573
...LVRRL	931	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89574
...LVRRL	931	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89572

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	52	EFRY.\|.YGDG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1A_HUMAN	694	LVVL.\|.LSTV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)