Q8WUA4: General transcription factor 3C polypeptide 2

General Information

Protein names	- General transcription factor 3C polypeptide 2 - TF3C-beta - Transcription factor IIIC 110 kDa subunit - TFIIIC 110 kDa subunit - TFIIIC110 - Transcription factor IIIC subunit beta
Gene names	GTF3C2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WUA4

7 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDTCGVGYVA LGEAGPVGNM TVVDSPGQEV LNQLDVKTSS EMTSAEASVE MSLPTPLPGF
        70         80         90        100        110        120
EDSPDQRRLP PEQESLSRLE QPDLSSEMSK VSKPRASKPG RKRGGRTRKG PKRPQQPNPP
       130        140        150        160        170        180
SAPLVPGLLD QSNPLSTPMP KKRGRKSKAE LLLLKLSKDL DRPESQSPKR PPEDFETPSG
       190        200        210        220        230        240
ERPRRRAAQV ALLYLQELAE ELSTALPAPV SCPEGPKVSS PTKPKKIRQP AACPGGEEVD
       250        260        270        280        290        300
GAPRDEDFFL QVEAEDVEES EGPSESSSEP EPVVPRSTPR GSTSGKQKPH CRGMAPNGLP
       310        320        330        340        350        360
NHIMAPVWKC LHLTKDFREQ KHSYWEFAEW IPLAWKWHLL SELEAAPYLP QEEKSPLFSV
       370        380        390        400        410        420
QREGLPEDGT LYRINRFSSI TAHPERWDVS FFTGGPLWAL DWCPVPEGAG ASQYVALFSS
       430        440        450        460        470        480
PDMNETHPLS QLHSGPGLLQ LWGLGTLQQE SCPGNRAHFV YGIACDNGCI WDLKFCPSGA
       490        500        510        520        530        540
WELPGTPRKA PLLPRLGLLA LACSDGKVLL FSLPHPEALL AQQPPDAVKP AIYKVQCVAT
       550        560        570        580        590        600
LQVGSMQATD PSECGQCLSL AWMPTRPHQH LAAGYYNGMV VFWNLPTNSP LQRIRLSDGS
       610        620        630        640        650        660
LKLYPFQCFL AHDQAVRTLQ WCKANSHFLV SAGSDRKIKF WDLRRPYEPI NSIKRFLSTE
       670        680        690        700        710        720
LAWLLPYNGV TVAQDNCYAS YGLCGIHYID AGYLGFKAYF TAPRKGTVWS LSGSDWLGTI
       730        740        750        760        770        780
AAGDISGELI AAILPDMALN PINVKRPVER RFPIYKADLI PYQDSPEGPD HSSASSGVPN
       790        800        810        820        830        840
PPKARTYTET VNHHYLLFQD TDLGSFHDLL RREPMLRMQE GEGHSQLCLD RLQLEAIHKV
       850        860        870        880        890        900
RFSPNLDSYG WLVSGGQSGL VRIHFVRGLA SPLGHRMQLE SRAHFNAMFQ PSSPTRRPGF
       910
SPTSHRLLPT P

Isoforms

- Isoform 2 of General transcription factor 3C polypeptide 2

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WUA4-1-unknown	MDTCGV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WUA4-1-unknown	MDTCGV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91938
Q8WUA4-27-unknown	GQEVLN...	27	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171752
Q8WUA4-27-	GQEVLN...	27		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WUA4-52-	SLPTPL...	52		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WUA4-52-unknown	SLPTPL...	52	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173840
Q8WUA4-254-unknown	AEDVEE...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12941
Q8WUA4-254-unknown	AEDVEE...	254	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148593
Q8WUA4-256-unknown	DVEESE...	256	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12943
Q8WUA4-256-unknown	DVEESE...	256	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148688

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FLQVEA	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12941
...FLQVEA	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131967
...QVEAED	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12943
...QVEAED	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132063
...LLPTP	911	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	253	QVEA.\|.AEDV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	255	EAED.\|.DVEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)