Q8WUD4: Coiled-coil domain-containing protein 12

General Information

Protein names	- Coiled-coil domain-containing protein 12
Gene names	CCDC12
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WUD4

3 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE GEKHRELRLR
        70         80         90        100        110        120
NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE EVDLANLAPR KPDWDLKRDV
       130        140        150        160
AKKLEKLKKR TQRAIAELIR ERLKGQEDSL ASAVDAATEQ KTCDSD

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WUD4-1-Acetylation	MEATTA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WUD4-1-Acetylation	MEATTA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8WUD4-1-Acetylation	MEATTA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8WUD4-92-	AAKPEP...	92			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WUD4-92-	AAKPEP...	92			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q8WUD4-156-unknown	AATEQK...	156		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12945

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AKPVAV	81	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000473887
...KVKEQL	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387490
...ASAVDA	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12945
...TCDSD	166	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	155	AVDA.\|.AATE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)