Q8WUF5: RelA-associated inhibitor

General Information

Protein names	- RelA-associated inhibitor - Inhibitor of ASPP protein - Protein iASPP - NFkB-interacting protein 1 - PPP1R13B-like protein
Gene names	PPP1R13L
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WUF5

7 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDSEAFQSAR DFLDMNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW SDSPAPPGPQ
        70         80         90        100        110        120
AGPPSRPPRY SSSSIPEPFG SRGSPRKAAT DGADTPFGRS ESAPTLHPYS PLSPKGRPSS
       130        140        150        160        170        180
PRTPLYLQPD AYGSLDRATS PRPRAFDGAG SSLGRAPSPR PGPGPLRQQG PPTPFDFLGR
       190        200        210        220        230        240
AGSPRGSPLA EGPQAFFPER GPSPRPPATA YDAPASAFGS SLLGSGGSAF APPLRAQDDL
       250        260        270        280        290        300
TLRRRPPKAW NESDLDVAYE KKPSQTASYE RLDVFARPAS PSLQLLPWRE SSLDGLGGTG
       310        320        330        340        350        360
KDNLTSATLP RNYKVSPLAS DRRSDAGSYR RSLGSAGPSG TLPRSWQPVS RIPMPPSSPQ
       370        380        390        400        410        420
PRGAPRQRPI PLSMIFKLQN AFWEHGASRA MLPGSPLFTR APPPKLQPQP QPQPQPQSQP
       430        440        450        460        470        480
QPQLPPQPQT QPQTPTPAPQ HPQQTWPPVN EGPPKPPTEL EPEPEIEGLL TPVLEAGDVD
       490        500        510        520        530        540
EGPVARPLSP TRLQPALPPE AQSVPELEEV ARVLAEIPRP LKRRGSMEQA PAVALPPTHK
       550        560        570        580        590        600
KQYQQIISRL FHRHGGPGPG GPEPELSPIT EGSEARAGPP APAPPAPIPP PAPSQSSPPE
       610        620        630        640        650        660
QPQSMEMRSV LRKAGSPRKA RRARLNPLVL LLDAALTGEL EVVQQAVKEM NDPSQPNEEG
       670        680        690        700        710        720
ITALHNAICG ANYSIVDFLI TAGANVNSPD SHGWTPLHCA ASCNDTVICM ALVQHGAAIF
       730        740        750        760        770        780
ATTLSDGATA FEKCDPYREG YADCATYLAD VEQSMGLMNS GAVYALWDYS AEFGDELSFR
       790        800        810        820
EGESVTVLRR DGPEETDWWW AALHGQEGYV PRNYFGLFPR VKPQRSKV

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WUF5-1-Acetylation	MDSEAF...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WUF5-1-Acetylation	MDSEAF...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8WUF5-107-unknown	HPYSPL...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18060
Q8WUF5-295-	GLGGTG...	295			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8WUF5-295-	GLGGTG...	295			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WUF5-295-unknown	GLGGTG...	295			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8WUF5-332-unknown	SLGSAG...	332			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8WUF5-332-	SLGSAG...	332			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8WUF5-795-unknown	ETDWWW...	795		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466555

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPGPQA	60	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467471
...SAPTLH	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18060
...PLYLQP	128	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466730
...QRSKV	828	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	106	PTLH.\|.HPYS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)