Q8WW12: PEST proteolytic signal-containing nuclear protein

General Information

Protein names	- PEST proteolytic signal-containing nuclear protein - PCNP - PEST-containing nuclear protein
Gene names	PCNP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WW12

17 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of PEST proteolytic signal-containing nuclear protein - Isoform 3 of PEST proteolytic signal-containing nuclear protein

Sequence View

        10         20         30         40         50         60
MADGKAGDEK PEKSQRAGAA GGPEEEAEKP VKTKTVSSSN GGESSSRSAE KRSAEEEAAD
        70         80         90        100        110        120
LPTKPTKISK FGFAIGSQTT KKASAISIKL GSSKPKETVP TLAPKTLSVA AAFNEDEDSE
       130        140        150        160        170
PEEMPPEAKM RMKNIGRDTP TSAGPNSFNK GKHGFSDNQK LWERNIKSHL GNVHDQDN         10         20         30         40         50         60
MADGKAGDEK PEKSQRAGAA GGPEEEAEKP VKTKTVSSSN GGESSSRSAE KRSAEEEAAD
        70         80         90        100        110        120
LPTKPTKISK FGFAIGSQTT KKASAISIKL GSSKPKETVP TLAPKTLSVA AAFNEDEDSE
       130        140        150        160        170
PEEMPPEAKM RMKNIGRDTP TSAGPNSFNK GKHGFSDNQK LWERNIKSHL GNVHDQDN

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WW12-2-unknown	MADGKA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WW12-2-unknown	MADGKA...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8WW12-1-unknown	MADGKA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84580
Q8WW12-2-Acetylation	ADGKAG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WW12-2-Acetylation	ADGKAG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8WW12-2-Acetylation	ADGKAG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110100
Q8WW12-21-unknown	GGPEEE...	21		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164835
Q8WW12-21-	GGPEEE...	21			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8WW12-21-	GGPEEE...	21			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8WW12-21-	GGPEEE...	21			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q8WW12-68-unknown	ISKFGF...	68			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8WW12-68-unknown	ISKFGF...	68		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160057
Q8WW12-68-	ISKFGF...	68			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8WW12-68-	ISKFGF...	68			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q8WW12-72-unknown	GFAIGS...	72			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8WW12-72-unknown	GFAIGS...	72			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8WW12-72-unknown	GFAIGS...	72		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160055
Q8WW12-72-	GFAIGS...	72			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
Q8WW12-72-	GFAIGS...	72			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8WW12-72-	GFAIGS...	72			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8WW12-73-	FAIGSQ...	73			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q8WW12-73-unknown	FAIGSQ...	73		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177346
Q8WW12-92-	SSKPKE...	92			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WW12-92-	SSKPKE...	92			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8WW12-92-unknown	SSKPKE...	92		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172430
Q8WW12-108-	SVAAAF...	108			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WW12-108-	SVAAAF...	108			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8WW12-109-	VAAAFN...	109			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8WW12-109-	VAAAFN...	109			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8WW12-111-	AAFNED...	111			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8WW12-111-	AAFNED...	111			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8WW12-124-unknown	MPPEAK...	124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84581

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...HDQDN	178	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...HDQDN	178	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt80199

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)