Q8WWY3: U4/U6 small nuclear ribonucleoprotein Prp31

General Information

Protein names	- U4/U6 small nuclear ribonucleoprotein Prp31 - Pre-mRNA-processing factor 31 - Serologically defined breast cancer antigen NY-BR-99 - U4/U6 snRNP 61 kDa protein - Protein 61K - hPrp31
Gene names	PRPF31
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WWY3

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp31 - Isoform 3 of U4/U6 small nuclear ribonucleoprotein Prp31 - Isoform 4 of U4/U6 small nuclear ribonucleoprotein Prp31

Sequence View

        10         20         30         40         50         60
MSLADELLAD LEEAAEEEEG GSYGEEEEEP AIEDVQEETQ LDLSGDSVKT IAKLWDSKMF
        70         80         90        100        110        120
AEIMMKIEEY ISKQAKASEV MGPVEAAPEY RVIVDANNLT VEIENELNII HKFIRDKYSK
       130        140        150        160        170        180
RFPELESLVP NALDYIRTVK ELGNSLDKCK NNENLQQILT NATIMVVSVT ASTTQGQQLS
       190        200        210        220        230        240
EEELERLEEA CDMALELNAS KHRIYEYVES RMSFIAPNLS IIIGASTAAK IMGVAGGLTN
       250        260        270        280        290        300
LSKMPACNIM LLGAQRKTLS GFSSTSVLPH TGYIYHSDIV QSLPPDLRRK AARLVAAKCT
       310        320        330        340        350        360
LAARVDSFHE STEGKVGYEL KDEIERKFDK WQEPPPVKQV KPLPAPLDGQ RKKRGGRRYR
       370        380        390        400        410        420
KMKERLGLTE IRKQANRMSF GEIEEDAYQE DLGFSLGHLG KSGSGRVRQT QVNEATKARI
       430        440        450        460        470        480
SKTLQRTLQK QSVVYGGKST IRDRSSGTAS SVAFTPLQGL EIVNPQAAEK KVAEANQKYF
       490
SSMAEFLKVK GEKSGLMST         10         20         30         40         50         60
MSLADELLAD LEEAAEEEEG GSYGEEEEEP AIEDVQEETQ LDLSGDSVKT IAKLWDSKMF
        70         80         90        100        110        120
AEIMMKIEEY ISKQAKASEV MGPVEAAPEY RVIVDANNLT VEIENELNII HKFIRDKYSK
       130        140        150        160        170        180
RFPELESLVP NALDYIRTVK ELGNSLDKCK NNENLQQILT NATIMVVSVT ASTTQGQQLS
       190        200        210        220        230        240
EEELERLEEA CDMALELNAS KHRIYEYVES RMSFIAPNLS IIIGASTAAK IMGVAGGLTN
       250        260        270        280        290        300
LSKMPACNIM LLGAQRKTLS GFSSTSVLPH TGYIYHSDIV QSLPPDLRRK AARLVAAKCT
       310        320        330        340        350        360
LAARVDSFHE STEGKVGYEL KDEIERKFDK WQEPPPVKQV KPLPAPLDGQ RKKRGGRRYR
       370        380        390        400        410        420
KMKERLGLTE IRKQANRMSF GEIEEDAYQE DLGFSLGHLG KSGSGRVRQT QVNEATKARI
       430        440        450        460        470        480
SKTLQRTLQK QSVVYGGKST IRDRSSGTAS SVAFTPLQGL EIVNPQAAEK KVAEANQKYF
       490
SSMAEFLKVK GEKSGLMST         10         20         30         40         50         60
MSLADELLAD LEEAAEEEEG GSYGEEEEEP AIEDVQEETQ LDLSGDSVKT IAKLWDSKMF
        70         80         90        100        110        120
AEIMMKIEEY ISKQAKASEV MGPVEAAPEY RVIVDANNLT VEIENELNII HKFIRDKYSK
       130        140        150        160        170        180
RFPELESLVP NALDYIRTVK ELGNSLDKCK NNENLQQILT NATIMVVSVT ASTTQGQQLS
       190        200        210        220        230        240
EEELERLEEA CDMALELNAS KHRIYEYVES RMSFIAPNLS IIIGASTAAK IMGVAGGLTN
       250        260        270        280        290        300
LSKMPACNIM LLGAQRKTLS GFSSTSVLPH TGYIYHSDIV QSLPPDLRRK AARLVAAKCT
       310        320        330        340        350        360
LAARVDSFHE STEGKVGYEL KDEIERKFDK WQEPPPVKQV KPLPAPLDGQ RKKRGGRRYR
       370        380        390        400        410        420
KMKERLGLTE IRKQANRMSF GEIEEDAYQE DLGFSLGHLG KSGSGRVRQT QVNEATKARI
       430        440        450        460        470        480
SKTLQRTLQK QSVVYGGKST IRDRSSGTAS SVAFTPLQGL EIVNPQAAEK KVAEANQKYF
       490
SSMAEFLKVK GEKSGLMST

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WWY3-1-unknown	MSLADE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WWY3-1-unknown	MSLADE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86265
Q8WWY3-81-unknown	MGPVEA...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86266
Q8WWY3-81-unknown	MGPVEA...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109776
Q8WWY3-387-unknown	AYQEDL...	387	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12950
Q8WWY3-387-	AYQEDL...	387		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8WWY3-387-	AYQEDL...	387		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WWY3-387-	AYQEDL...	387		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RGGRRY	358	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81884
...EIEEDA	386	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12950
...GLMST	499	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	386	EEDA.\|.AYQE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)