Q8WXA9: Splicing regulatory glutamine/lysine-rich protein 1

General Information

Protein names	- Splicing regulatory glutamine/lysine-rich protein 1 - Serine/arginine-rich-splicing regulatory protein 86 - SRrp86 - Splicing factor, arginine/serine-rich 12 - Splicing regulatory protein 508 - SRrp508
Gene names	SREK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WXA9

10 N-termini

7 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTSLMPGAGL LPIPTPNPLT TLGVSLSSLG AIPAAALDPN IATLGEIPQP PLMGNVDPSK
        70         80         90        100        110        120
IDEIRRTVYV GNLNSQTTTA DQLLEFFKQV GEVKFVRMAG DETQPTRFAF VEFADQNSVP
       130        140        150        160        170        180
RALAFNGVMF GDRPLKINHS NNAIVKPPEM TPQAAAKELE EVMKRVREAQ SFISAAIEPE
       190        200        210        220        230        240
SGKSNERKGG RSRSHTRSKS RSSSKSHSRR KRSQSKHRSR SHNRSRSRQK DRRRSKSPHK
       250        260        270        280        290        300
KRSKSRERRK SRSRSHSRDK RKDTREKIKE KERVKEKDRE KEREREKERE KEKERGKNKD
       310        320        330        340        350        360
RDKEREKDRE KDKEKDRERE REKEHEKDRD KEKEKEQDKE KEREKDRSKE IDEKRKKDKK
       370        380        390        400        410        420
SRTPPRSYNA SRRSRSSSRE RRRRRSRSSS RSPRTSKTIK RKSSRSPSPR SRNKKDKKRE
       430        440        450        460        470        480
KERDHISERR ERERSTSMRK SSNDRDGKEK LEKNSTSLKE KEHNKEPDSS VSKEVDDKDA
       490        500
PRTEENKIQH NGNCQLNEEN LSTKTEAV

Isoforms

- Isoform 2 of Splicing regulatory glutamine/lysine-rich protein 1

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 7 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WXA9-1-unknown	MTSLMP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WXA9-1-unknown	MTSLMP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105797
Q8WXA9-31-	AIPAAA...	31		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8WXA9-31-unknown	AIPAAA...	31	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178043
Q8WXA9-171-	SFISAA...	171		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8WXA9-171-	SFISAA...	171		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8WXA9-171-unknown	SFISAA...	171	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14791
Q8WXA9-171-unknown	SFISAA...	171	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149529
Q8WXA9-174-unknown	SAAIEP...	174	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14793
Q8WXA9-174-unknown	SAAIEP...	174	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149587
Q8WXA9-181-unknown	SGKSNE...	181	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12951
Q8WXA9-181-unknown	SGKSNE...	181	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149798
Q8WXA9-469-unknown	SSVSKE...	469	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12953
Q8WXA9-469-unknown	SSVSKE...	469	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14795
Q8WXA9-469-unknown	SSVSKE...	469	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154394
Q8WXA9-472-unknown	SKEVDD...	472	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12955
Q8WXA9-472-unknown	SKEVDD...	472	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154436
Q8WXA9-490-unknown	HNGNCQ...	490	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12957
Q8WXA9-490-unknown	HNGNCQ...	490	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154661

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VREAQS	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14791
...VREAQS	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132914
...AQSFIS	173	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14793
...AQSFIS	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132975
...AIEPES	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12951
...AIEPES	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133189
...NKEPDS	468	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12953
...NKEPDS	468	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14795
...NKEPDS	468	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137815
...PDSSVS	471	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12955
...PDSSVS	471	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137857
...ENKIQH	489	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12957
...ENKIQH	489	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138086
...KTEAV	508	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KTEAV	508	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86291

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	170	EAQS.\|.SFIS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	173	SFIS.\|.SAAI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	180	EPES.\|.SGKS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	468	EPDS.\|.SSVS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	468	EPDS.\|.SSVS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	471	SSVS.\|.SKEV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	489	KIQH.\|.HNGN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)