Q92499: ATP-dependent RNA helicase DDX1

General Information

Protein names	- ATP-dependent RNA helicase DDX1 - 3.6.4.13 - DEAD box protein 1 - DEAD box protein retinoblastoma - DBP-RB
Gene names	DDX1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92499

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of ATP-dependent RNA helicase DDX1 - Isoform 3 of ATP-dependent RNA helicase DDX1

Sequence View

        10         20         30         40         50         60
MAAFSEMGVM PEIAQAVEEM DWLLPTDIQA ESIPLILGGG DVLMAAETGS GKTGAFSIPV
        70         80         90        100        110        120
IQIVYETLKD QQEGKKGKTT IKTGASVLNK WQMNPYDRGS AFAIGSDGLC CQSREVKEWH
       130        140        150        160        170        180
GCRATKGLMK GKHYYEVSCH DQGLCRVGWS TMQASLDLGT DKFGFGFGGT GKKSHNKQFD
       190        200        210        220        230        240
NYGEEFTMHD TIGCYLDIDK GHVKFSKNGK DLGLAFEIPP HMKNQALFPA CVLKNAELKF
       250        260        270        280        290        300
NFGEEEFKFP PKDGFVALSK APDGYIVKSQ HSGNAQVTQT KFLPNAPKAL IVEPSRELAE
       310        320        330        340        350        360
QTLNNIKQFK KYIDNPKLRE LLIIGGVAAR DQLSVLENGV DIVVGTPGRL DDLVSTGKLN
       370        380        390        400        410        420
LSQVRFLVLD EADGLLSQGY SDFINRMHNQ IPQVTSDGKR LQVIVCSATL HSFDVKKLSE
       430        440        450        460        470        480
KIMHFPTWVD LKGEDSVPDT VHHVVVPVNP KTDRLWERLG KSHIRTDDVH AKDNTRPGAN
       490        500        510        520        530        540
SPEMWSEAIK ILKGEYAVRA IKEHKMDQAI IFCRTKIDCD NLEQYFIQQG GGPDKKGHQF
       550        560        570        580        590        600
SCVCLHGDRK PHERKQNLER FKKGDVRFLI CTDVAARGID IHGVPYVINV TLPDEKQNYV
       610        620        630        640        650        660
HRIGRVGRAE RMGLAISLVA TEKEKVWYHV CSSRGKGCYN TRLKEDGGCT IWYNEMQLLS
       670        680        690        700        710        720
EIEEHLNCTI SQVEPDIKVP VDEFDGKVTY GQKRAAGGGS YKGHVDILAP TVQELAALEK
       730        740
EAQTSFLHLG YLPNQLFRTF         10         20         30         40         50         60
MAAFSEMGVM PEIAQAVEEM DWLLPTDIQA ESIPLILGGG DVLMAAETGS GKTGAFSIPV
        70         80         90        100        110        120
IQIVYETLKD QQEGKKGKTT IKTGASVLNK WQMNPYDRGS AFAIGSDGLC CQSREVKEWH
       130        140        150        160        170        180
GCRATKGLMK GKHYYEVSCH DQGLCRVGWS TMQASLDLGT DKFGFGFGGT GKKSHNKQFD
       190        200        210        220        230        240
NYGEEFTMHD TIGCYLDIDK GHVKFSKNGK DLGLAFEIPP HMKNQALFPA CVLKNAELKF
       250        260        270        280        290        300
NFGEEEFKFP PKDGFVALSK APDGYIVKSQ HSGNAQVTQT KFLPNAPKAL IVEPSRELAE
       310        320        330        340        350        360
QTLNNIKQFK KYIDNPKLRE LLIIGGVAAR DQLSVLENGV DIVVGTPGRL DDLVSTGKLN
       370        380        390        400        410        420
LSQVRFLVLD EADGLLSQGY SDFINRMHNQ IPQVTSDGKR LQVIVCSATL HSFDVKKLSE
       430        440        450        460        470        480
KIMHFPTWVD LKGEDSVPDT VHHVVVPVNP KTDRLWERLG KSHIRTDDVH AKDNTRPGAN
       490        500        510        520        530        540
SPEMWSEAIK ILKGEYAVRA IKEHKMDQAI IFCRTKIDCD NLEQYFIQQG GGPDKKGHQF
       550        560        570        580        590        600
SCVCLHGDRK PHERKQNLER FKKGDVRFLI CTDVAARGID IHGVPYVINV TLPDEKQNYV
       610        620        630        640        650        660
HRIGRVGRAE RMGLAISLVA TEKEKVWYHV CSSRGKGCYN TRLKEDGGCT IWYNEMQLLS
       670        680        690        700        710        720
EIEEHLNCTI SQVEPDIKVP VDEFDGKVTY GQKRAAGGGS YKGHVDILAP TVQELAALEK
       730        740
EAQTSFLHLG YLPNQLFRTF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q92499-1-unknown	MAAFSE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92499-79-	TTIKTG...	79		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q92499-79-	TTIKTG...	79		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q92499-79-unknown	TTIKTG...	79		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92499-139-unknown	CHDQGL...	139	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7972
Q92499-374-	GLLSQG...	374		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92499-436-	SVPDTV...	436		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92499-440-	TVHHVV...	440		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92499-440-	TVHHVV...	440		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92499-686-unknown	GKVTYG...	686	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2276

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YYEVSC	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7972
...VDEFDG	685	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2276
...LFRTF	740	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	138	EVSC.\|.CHDQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP3_HUMAN	685	EFDG.\|.GKVT	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> DDX1_HUMAN @685

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)