Q92608: Dedicator of cytokinesis protein 2

General Information

Protein names	- Dedicator of cytokinesis protein 2
Gene names	DOCK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92608

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPWRKADKE RHGVAIYNFQ GSGAPQLSLQ IGDVVRIQET CGDWYRGYLI KHKMLQGIFP
        70         80         90        100        110        120
KSFIHIKEVT VEKRRNTENI IPAEIPLAQE VTTTLWEWGS IWKQLYVASK KERFLQVQSM
       130        140        150        160        170        180
MYDLMEWRSQ LLSGTLPKDE LKELKQKVTS KIDYGNKILE LDLIVRDEDG NILDPDNTSV
       190        200        210        220        230        240
ISLFHAHEEA TDKITERIKE EMSKDQPDYA MYSRISSSPT HSLYVFVRNF VCRIGEDAEL
       250        260        270        280        290        300
FMSLYDPNKQ TVISENYLVR WGSRGFPKEI EMLNNLKVVF TDLGNKDLNR DKIYLICQIV
       310        320        330        340        350        360
RVGKMDLKDT GAKKCTQGLR RPFGVAVMDI TDIIKGKAES DEEKQHFIPF HPVTAENDFL
       370        380        390        400        410        420
HSLLGKVIAS KGDSGGQGLW VTMKMLVGDI IQIRKDYPHL VDRTTVVARK LGFPEIIMPG
       430        440        450        460        470        480
DVRNDIYITL LQGDFDKYNK TTQRNVEVIM CVCAEDGKTL PNAICVGAGD KPMNEYRSVV
       490        500        510        520        530        540
YYQVKQPRWM ETVKVAVPIE DMQRIHLRFM FRHRSSLESK DKGEKNFAMS YVKLMKEDGT
       550        560        570        580        590        600
TLHDGFHDLV VLKGDSKKME DASAYLTLPS YRHHVENKGA TLSRSSSSVG GLSVSSRDVF
       610        620        630        640        650        660
SISTLVCSTK LTQNVGLLGL LKWRMKPQLL QENLEKLKIV DGEEVVKFLQ DTLDALFNIM
       670        680        690        700        710        720
MEHSQSDEYD ILVFDALIYI IGLIADRKFQ HFNTVLEAYI QQHFSATLAY KKLMTVLKTY
       730        740        750        760        770        780
LDTSSRGEQC EPILRTLKAL EYVFKFIVRS RTLFSQLYEG KEQMEFEESM RRLFESINNL
       790        800        810        820        830        840
MKSQYKTTIL LQVAALKYIP SVLHDVEMVF DAKLLSQLLY EFYTCIPPVK LQKQKVQSMN
       850        860        870        880        890        900
EIVQSNLFKK QECRDILLPV ITKELKELLE QKDDMQHQVL ERKYCVELLN SILEVLSYQD
       910        920        930        940        950        960
AAFTYHHIQE IMVQLLRTVN RTVITMGRDH ILISHFVACM TAILNQMGDQ HYSFYIETFQ
       970        980        990       1000       1010       1020
TSSELVDFLM ETFIMFKDLI GKNVYPGDWM AMSMVQNRVF LRAINKFAET MNQKFLEHTN
      1030       1040       1050       1060       1070       1080
FEFQLWNNYF HLAVAFITQD SLQLEQFSHA KYNKILNKYG DMRRLIGFSI RDMWYKLGQN
      1090       1100       1110       1120       1130       1140
KICFIPGMVG PILEMTLIPE AELRKATIPI FFDMMLCEYQ RSGDFKKFEN EIILKLDHEV
      1150       1160       1170       1180       1190       1200
EGGRGDEQYM QLLESILMEC AAEHPTIAKS VENFVNLVKG LLEKLLDYRG VMTDESKDNR
      1210       1220       1230       1240       1250       1260
MSCTVNLLNF YKDNNREEMY IRYLYKLRDL HLDCDNYTEA AYTLLLHTWL LKWSDEQCAS
      1270       1280       1290       1300       1310       1320
QVMQTGQQHP QTHRQLKETL YETIIGYFDK GKMWEEAISL CKELAEQYEM EIFDYELLSQ
      1330       1340       1350       1360       1370       1380
NLIQQAKFYE SIMKILRPKP DYFAVGYYGQ GFPSFLRNKV FIYRGKEYER REDFQMQLMT
      1390       1400       1410       1420       1430       1440
QFPNAEKMNT TSAPGDDVKN APGQYIQCFT VQPVLDEHPR FKNKPVPDQI INFYKSNYVQ
      1450       1460       1470       1480       1490       1500
RFHYSRPVRR GTVDPENEFA SMWIERTSFV TAYKLPGILR WFEVVHMSQT TISPLENAIE
      1510       1520       1530       1540       1550       1560
TMSTANEKIL MMINQYQSDE TLPINPLSML LNGIVDPAVM GGFAKYEKAF FTEEYVRDHP
      1570       1580       1590       1600       1610       1620
EDQDKLTHLK DLIAWQIPFL GAGIKIHEKR VSDNLRPFHD RMEECFKNLK MKVEKEYGVR
      1630       1640       1650       1660       1670       1680
EMPDFDDRRV GRPRSMLRSY RQMSIISLAS MNSDCSTPSK PTSESFDLEL ASPKTPRVEQ
      1690       1700       1710       1720       1730       1740
EEPISPGSTL PEVKLRRSKK RTKRSSVVFA DEKAAAESDL KRLSRKHEFM SDTNLSEHAA
      1750       1760       1770       1780       1790       1800
IPLKASVLSQ MSFASQSMPT IPALALSVAG IPGLDEANTS PRLSQTFLQL SDGDKKTLTR
      1810       1820       1830
KKVNQFFKTM LASKSAEEGK QIPDSLSTDL

Isoforms

- Isoform 2 of Dedicator of cytokinesis protein 2

Sequence View

        10         20         30         40         50         60
MAPWRKADKE RHGVAIYNFQ GSGAPQLSLQ IGDVVRIQET CGDWYRGYLI KHKMLQGIFP
        70         80         90        100        110        120
KSFIHIKEVT VEKRRNTENI IPAEIPLAQE VTTTLWEWGS IWKQLYVASK KERFLQVQSM
       130        140        150        160        170        180
MYDLMEWRSQ LLSGTLPKDE LKELKQKVTS KIDYGNKILE LDLIVRDEDG NILDPDNTSV
       190        200        210        220        230        240
ISLFHAHEEA TDKITERIKE EMSKDQPDYA MYSRISSSPT HSLYVFVRNF VCRIGEDAEL
       250        260        270        280        290        300
FMSLYDPNKQ TVISENYLVR WGSRGFPKEI EMLNNLKVVF TDLGNKDLNR DKIYLICQIV
       310        320        330        340        350        360
RVGKMDLKDT GAKKCTQGLR RPFGVAVMDI TDIIKGKAES DEEKQHFIPF HPVTAENDFL
       370        380        390        400        410        420
HSLLGKVIAS KGDSGGQGLW VTMKMLVGDI IQIRKDYPHL VDRTTVVARK LGFPEIIMPG
       430        440        450        460        470        480
DVRNDIYITL LQGDFDKYNK TTQRNVEVIM CVCAEDGKTL PNAICVGAGD KPMNEYRSVV
       490        500        510        520        530        540
YYQVKQPRWM ETVKVAVPIE DMQRIHLRFM FRHRSSLESK DKGEKNFAMS YVKLMKEDGT
       550        560        570        580        590        600
TLHDGFHDLV VLKGDSKKME DASAYLTLPS YRHHVENKGA TLSRSSSSVG GLSVSSRDVF
       610        620        630        640        650        660
SISTLVCSTK LTQNVGLLGL LKWRMKPQLL QENLEKLKIV DGEEVVKFLQ DTLDALFNIM
       670        680        690        700        710        720
MEHSQSDEYD ILVFDALIYI IGLIADRKFQ HFNTVLEAYI QQHFSATLAY KKLMTVLKTY
       730        740        750        760        770        780
LDTSSRGEQC EPILRTLKAL EYVFKFIVRS RTLFSQLYEG KEQMEFEESM RRLFESINNL
       790        800        810        820        830        840
MKSQYKTTIL LQVAALKYIP SVLHDVEMVF DAKLLSQLLY EFYTCIPPVK LQKQKVQSMN
       850        860        870        880        890        900
EIVQSNLFKK QECRDILLPV ITKELKELLE QKDDMQHQVL ERKYCVELLN SILEVLSYQD
       910        920        930        940        950        960
AAFTYHHIQE IMVQLLRTVN RTVITMGRDH ILISHFVACM TAILNQMGDQ HYSFYIETFQ
       970        980        990       1000       1010       1020
TSSELVDFLM ETFIMFKDLI GKNVYPGDWM AMSMVQNRVF LRAINKFAET MNQKFLEHTN
      1030       1040       1050       1060       1070       1080
FEFQLWNNYF HLAVAFITQD SLQLEQFSHA KYNKILNKYG DMRRLIGFSI RDMWYKLGQN
      1090       1100       1110       1120       1130       1140
KICFIPGMVG PILEMTLIPE AELRKATIPI FFDMMLCEYQ RSGDFKKFEN EIILKLDHEV
      1150       1160       1170       1180       1190       1200
EGGRGDEQYM QLLESILMEC AAEHPTIAKS VENFVNLVKG LLEKLLDYRG VMTDESKDNR
      1210       1220       1230       1240       1250       1260
MSCTVNLLNF YKDNNREEMY IRYLYKLRDL HLDCDNYTEA AYTLLLHTWL LKWSDEQCAS
      1270       1280       1290       1300       1310       1320
QVMQTGQQHP QTHRQLKETL YETIIGYFDK GKMWEEAISL CKELAEQYEM EIFDYELLSQ
      1330       1340       1350       1360       1370       1380
NLIQQAKFYE SIMKILRPKP DYFAVGYYGQ GFPSFLRNKV FIYRGKEYER REDFQMQLMT
      1390       1400       1410       1420       1430       1440
QFPNAEKMNT TSAPGDDVKN APGQYIQCFT VQPVLDEHPR FKNKPVPDQI INFYKSNYVQ
      1450       1460       1470       1480       1490       1500
RFHYSRPVRR GTVDPENEFA SMWIERTSFV TAYKLPGILR WFEVVHMSQT TISPLENAIE
      1510       1520       1530       1540       1550       1560
TMSTANEKIL MMINQYQSDE TLPINPLSML LNGIVDPAVM GGFAKYEKAF FTEEYVRDHP
      1570       1580       1590       1600       1610       1620
EDQDKLTHLK DLIAWQIPFL GAGIKIHEKR VSDNLRPFHD RMEECFKNLK MKVEKEYGVR
      1630       1640       1650       1660       1670       1680
EMPDFDDRRV GRPRSMLRSY RQMSIISLAS MNSDCSTPSK PTSESFDLEL ASPKTPRVEQ
      1690       1700       1710       1720       1730       1740
EEPISPGSTL PEVKLRRSKK RTKRSSVVFA DEKAAAESDL KRLSRKHEFM SDTNLSEHAA
      1750       1760       1770       1780       1790       1800
IPLKASVLSQ MSFASQSMPT IPALALSVAG IPGLDEANTS PRLSQTFLQL SDGDKKTLTR
      1810       1820       1830
KKVNQFFKTM LASKSAEEGK QIPDSLSTDL

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q92608-1-unknown	MAPWRK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92608-585-unknown	SSSSVG...	585	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10454
Q92608-585-unknown	SSSSVG...	585	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142569
Q92608-1770-	GIPGLD...	1770		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q92608-1770-	GIPGLD...	1770		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92608-1770-	GIPGLD...	1770		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ATLSRS	584	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10454
...ATLSRS	584	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125763
...LSTDL	1830	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

TopFIND

Q92608: Dedicator of cytokinesis protein 2

General Information

3

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Methodology:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates