Q969V3: Nicalin

General Information

Protein names	- Nicalin - Nicastrin-like protein
Gene names	NCLN
Organism	Homo sapiens
Protease Family
Protease ID	M28.978
Chromosome location
UniProt ID	Q969V3

5 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLEEAGEVLE NMLKASCLPL GFIVFLPAVL LLVAPPLPAA DAAHEFTVYR MQQYDLQGQP
        70         80         90        100        110        120
YGTRNAVLNT EARTMAAEVL SRRCVLMRLL DFSYEQYQKA LRQSAGAVVI ILPRAMAAVP
       130        140        150        160        170        180
QDVVRQFMEI EPEMLAMETA VPVYFAVEDE ALLSIYKQTQ AASASQGSAS AAEVLLRTAT
       190        200        210        220        230        240
ANGFQMVTSG VQSKAVSDWL IASVEGRLTG LGGEDLPTIV IVAHYDAFGV APWLSLGADS
       250        260        270        280        290        300
NGSGVSVLLE LARLFSRLYT YKRTHAAYNL LFFASGGGKF NYQGTKRWLE DNLDHTDSSL
       310        320        330        340        350        360
LQDNVAFVLC LDTVGRGSSL HLHVSKPPRE GTLQHAFLRE LETVAAHQFP EVRFSMVHKR
       370        380        390        400        410        420
INLAEDVLAW EHERFAIRRL PAFTLSHLES HRDGQRSSIM DVRSRVDSKT LTRNTRIIAE
       430        440        450        460        470        480
ALTRVIYNLT EKGTPPDMPV FTEQMQIQQE QLDSVMDWLT NQPRAAQLVD KDSTFLSTLE
       490        500        510        520        530        540
HHLSRYLKDV KQHHVKADKR DPEFVFYDQL KQVMNAYRVK PAVFDLLLAV GIAAYLGMAY
       550        560
VAVQHFSLLY KTVQRLLVKA KTQ

Isoforms

- Isoform 2 of Nicalin

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q969V3-1-	MLEEAG...	1		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q969V3-1-unknown	MLEEAG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82402
Q969V3-43-unknown	AHEFTV...	43	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q969V3-43-unknown	AHEFTV...	43	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115485
Q969V3-43-	AHEFTV...	43		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q969V3-43-	AHEFTV...	43		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q969V3-43-	AHEFTV...	43		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q969V3-43-	AHEFTV...	43		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q969V3-43-	AHEFTV...	43		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q969V3-75-unknown	MAAEVL...	75	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466678
Q969V3-75-unknown	MAAEVL...	75	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196569

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PDMPVF	440	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467011
...KAKTQ	563	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KAKTQ	563	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78020

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)