Q96C57: Protein CUSTOS {ECO:0000250|UniProtKB:A9C3N6}

General Information

Protein names	- Protein CUSTOS {ECO:0000250\|UniProtKB:A9C3N6}
Gene names	C12orf43
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96C57

6 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAPSGTVSD SESSNSSSDA EELERCREAA MPAWGLEQRP HVAGKPRAGA ANSQLSTSQP
        70         80         90        100        110        120
SLRHKVNEHE QDGNELQTTP EFRAHVAKKL GALLDSFITI SEAAKEPAKA KVQKVALEDD
       130        140        150        160        170        180
GFRLFFTSVP GGREKEESPQ PRRKRQPSSS SEDSDEEWRR CREAAVSASD ILQESAIHSP
       190        200        210        220        230        240
GTVEKEAKKK RKLKKKAKKV ASVDSAVAAT TPTSMATVQK QKSGELNGDQ VSLGTKKKKK
       250        260
AKKASETSPF PPAKSATAIP AN

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96C57-1-unknown	MAAPSG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96C57-31-unknown	MPAWGL...	31	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409788
Q96C57-31-unknown	MPAWGL...	31	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442224
Q96C57-31-unknown	MPAWGL...	31	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442041
Q96C57-53-	SQLSTS...	53		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96C57-73-	GNELQT...	73		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96C57-175-unknown	SAIHSP...	175	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13052
Q96C57-205-	SAVAAT...	205		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96C57-205-	SAVAAT...	205		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96C57-205-	SAVAAT...	205		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DILQES	174	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13052
...DQVSLG	233	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438856
...KKKAKK	242	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442041
...AIPAN	262	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	174	LQES.\|.SAIH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)