Q96CB8: Integrator complex subunit 12

General Information

Protein names	- Integrator complex subunit 12 - Int12 - PHD finger protein 22
Gene names	INTS12
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96CB8

3 N-termini

7 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS QKDVEPPKIS
        70         80         90        100        110        120
STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP ADKMKSDITE GVDIPKKPRL
       130        140        150        160        170        180
EKPETQSSPI TVQSSKDLPM ADLSSFEETS ADDFAMEMGL ACVVCRQMMV ASGNQLVECQ
       190        200        210        220        230        240
ECHNLYHRDC HKPQVTDKEA NDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APAVVSVTPA
       250        260        270        280        290        300
VKDPLVKKPE TKLKQETTFL AFKRTEVKTS TVISGNSSSA SVSSSVTSGL TGWAAFAAKT
       310        320        330        340        350        360
SSAGPSTAKL SSTTQNNTGK PATSSANQKP VGLTGLATSS KGGIGSKIGS NNSTTPTVPL
       370        380        390        400        410        420
KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ LSGNGNSGTS GPSGSTTSKT
       430        440        450        460
TSESSSSPSA SLKGPTSQES QLNAMKRLQM VKKKAAQKKL KK

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 7 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96CB8-1-unknown	MAATVN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96CB8-111-	GVDIPK...	111		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96CB8-246-unknown	VKKPET...	246	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14823

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ARGIDS	44	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422856
...NGKVLT	87	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396729
...GKVLTT	88	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396309
...SSPITV	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412317
...AMEMGL	159	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423618
...VKDPLV	245	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14823
...KKLKK	462	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	245	DPLV.\|.VKKP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)