Q96HN2: Adenosylhomocysteinase 3

General Information

Protein names	- Adenosylhomocysteinase 3 - AdoHcyase 3 - 3.3.1.1 - IP(3)Rs binding protein released with IP(3) 2 - IRBIT2 - Long-IRBIT {ECO:0000303\|PubMed:19220705} - S-adenosyl-L-homocysteine hydrolase 3 - S-adenosylhomocysteine hydrolase-like protein 2
Gene names	AHCYL2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96HN2

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Putative adenosylhomocysteinase 3 - Isoform 3 of Putative adenosylhomocysteinase 3 - Isoform 4 of Putative adenosylhomocysteinase 3 - Isoform 2 of Adenosylhomocysteinase 3 - Isoform 3 of Adenosylhomocysteinase 3 - Isoform 4 of Adenosylhomocysteinase 3

Sequence View

        10         20         30         40         50         60
MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP
        70         80         90        100        110        120
PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK
       130        140        150        160        170        180
KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS
       190        200        210        220        230        240
KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA
       250        260        270        280        290        300
VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE
       310        320        330        340        350        360
GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN
       370        380        390        400        410        420
DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV
       430        440        450        460        470        480
TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH
       490        500        510        520        530        540
SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA
       550        560        570        580        590        600
TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK
       610
NGPFKPNYYR Y         10         20         30         40         50         60
MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP
        70         80         90        100        110        120
PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK
       130        140        150        160        170        180
KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS
       190        200        210        220        230        240
KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA
       250        260        270        280        290        300
VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE
       310        320        330        340        350        360
GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN
       370        380        390        400        410        420
DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV
       430        440        450        460        470        480
TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH
       490        500        510        520        530        540
SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA
       550        560        570        580        590        600
TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK
       610
NGPFKPNYYR Y         10         20         30         40         50         60
MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP
        70         80         90        100        110        120
PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK
       130        140        150        160        170        180
KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS
       190        200        210        220        230        240
KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA
       250        260        270        280        290        300
VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE
       310        320        330        340        350        360
GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN
       370        380        390        400        410        420
DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV
       430        440        450        460        470        480
TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH
       490        500        510        520        530        540
SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA
       550        560        570        580        590        600
TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK
       610
NGPFKPNYYR Y         10         20         30         40         50         60
MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP
        70         80         90        100        110        120
PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK
       130        140        150        160        170        180
KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS
       190        200        210        220        230        240
KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA
       250        260        270        280        290        300
VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE
       310        320        330        340        350        360
GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN
       370        380        390        400        410        420
DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV
       430        440        450        460        470        480
TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH
       490        500        510        520        530        540
SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA
       550        560        570        580        590        600
TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK
       610
NGPFKPNYYR Y         10         20         30         40         50         60
MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP
        70         80         90        100        110        120
PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK
       130        140        150        160        170        180
KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS
       190        200        210        220        230        240
KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA
       250        260        270        280        290        300
VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE
       310        320        330        340        350        360
GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN
       370        380        390        400        410        420
DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV
       430        440        450        460        470        480
TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH
       490        500        510        520        530        540
SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA
       550        560        570        580        590        600
TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK
       610
NGPFKPNYYR Y         10         20         30         40         50         60
MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP
        70         80         90        100        110        120
PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK
       130        140        150        160        170        180
KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS
       190        200        210        220        230        240
KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA
       250        260        270        280        290        300
VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE
       310        320        330        340        350        360
GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN
       370        380        390        400        410        420
DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV
       430        440        450        460        470        480
TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH
       490        500        510        520        530        540
SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA
       550        560        570        580        590        600
TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK
       610
NGPFKPNYYR Y

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96HN2-1-unknown	MSVQVV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88841
Q96HN2-2-unknown	MSVQVV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96HN2-2-Acetylation	SVQVVS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96HN2-2-Acetylation	SVQVVS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q96HN2-2-Acetylation	SVQVVS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111088
Q96HN2-110-	GTVTEA...	110			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96HN2-155-	SYSSAA...	155			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96HN2-155-	SYSSAA...	155			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96HN2-155-unknown	SYSSAA...	155		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173851
Q96HN2-155-unknown	SYSSAA...	155		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173852
Q96HN2-155-unknown	SYSSAA...	155		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173853
Q96HN2-335-unknown	ESVTGV...	335		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8024
Q96HN2-335-unknown	ESVTGV...	335		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147805
Q96HN2-335-unknown	ESVTGV...	335		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147806
Q96HN2-335-unknown	ESVTGV...	335		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150600

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KGIVEE	334	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8024
...KGIVEE	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131160
...KGIVEE	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131161
...KGIVEE	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133998
...NYYRY	611	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NYYRY	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84460
...NYYRY	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84461
...NYYRY	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84459

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	334	IVEE.\|.ESVT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)