Q96N16: Janus kinase and microtubule-interacting protein 1

General Information

Protein names	- Janus kinase and microtubule-interacting protein 1 - GABA-B receptor-binding protein - Multiple alpha-helices and RNA-linker protein 1 - Marlin-1
Gene names	JAKMIP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96N16

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Janus kinase and microtubule-interacting protein 1 - Isoform 3 of Janus kinase and microtubule-interacting protein 1 - Isoform 4 of Janus kinase and microtubule-interacting protein 1 - Isoform 5 of Janus kinase and microtubule-interacting protein 1 - Isoform 6 of Janus kinase and microtubule-interacting protein 1 - Isoform 7 of Janus kinase and microtubule-interacting protein 1

Sequence View

        10         20         30         40         50         60
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ
        70         80         90        100        110        120
EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL
       130        140        150        160        170        180
RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA
       190        200        210        220        230        240
ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK
       250        260        270        280        290        300
EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV
       310        320        330        340        350        360
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL
       370        380        390        400        410        420
TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL
       430        440        450        460        470        480
RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA
       490        500        510        520        530        540
REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE
       550        560        570        580        590        600
KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE
       610        620
LEVRDSICCK LSNGADILFE PKLKFM         10         20         30         40         50         60
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ
        70         80         90        100        110        120
EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL
       130        140        150        160        170        180
RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA
       190        200        210        220        230        240
ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK
       250        260        270        280        290        300
EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV
       310        320        330        340        350        360
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL
       370        380        390        400        410        420
TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL
       430        440        450        460        470        480
RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA
       490        500        510        520        530        540
REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE
       550        560        570        580        590        600
KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE
       610        620
LEVRDSICCK LSNGADILFE PKLKFM         10         20         30         40         50         60
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ
        70         80         90        100        110        120
EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL
       130        140        150        160        170        180
RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA
       190        200        210        220        230        240
ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK
       250        260        270        280        290        300
EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV
       310        320        330        340        350        360
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL
       370        380        390        400        410        420
TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL
       430        440        450        460        470        480
RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA
       490        500        510        520        530        540
REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE
       550        560        570        580        590        600
KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE
       610        620
LEVRDSICCK LSNGADILFE PKLKFM         10         20         30         40         50         60
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ
        70         80         90        100        110        120
EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL
       130        140        150        160        170        180
RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA
       190        200        210        220        230        240
ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK
       250        260        270        280        290        300
EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV
       310        320        330        340        350        360
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL
       370        380        390        400        410        420
TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL
       430        440        450        460        470        480
RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA
       490        500        510        520        530        540
REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE
       550        560        570        580        590        600
KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE
       610        620
LEVRDSICCK LSNGADILFE PKLKFM         10         20         30         40         50         60
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ
        70         80         90        100        110        120
EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL
       130        140        150        160        170        180
RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA
       190        200        210        220        230        240
ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK
       250        260        270        280        290        300
EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV
       310        320        330        340        350        360
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL
       370        380        390        400        410        420
TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL
       430        440        450        460        470        480
RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA
       490        500        510        520        530        540
REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE
       550        560        570        580        590        600
KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE
       610        620
LEVRDSICCK LSNGADILFE PKLKFM         10         20         30         40         50         60
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ
        70         80         90        100        110        120
EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL
       130        140        150        160        170        180
RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA
       190        200        210        220        230        240
ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK
       250        260        270        280        290        300
EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV
       310        320        330        340        350        360
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL
       370        380        390        400        410        420
TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL
       430        440        450        460        470        480
RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA
       490        500        510        520        530        540
REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE
       550        560        570        580        590        600
KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE
       610        620
LEVRDSICCK LSNGADILFE PKLKFM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96N16-1-unknown	MSKKGR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96N16-1-unknown	MSKKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78321
Q96N16-1-unknown	MSKKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78322
Q96N16-1-unknown	MSKKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78323
Q96N16-1-unknown	MSKKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78324
Q96N16-1-unknown	MSKKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78326
Q96N16-18-	AVQMAN...	18		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96N16-18-	AVQMAN...	18		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q96N16-18-	AVQMAN...	18		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96N16-18-	AVQMAN...	18		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96N16-18-	AVQMAN...	18		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96N16-18-unknown	AVQMAN...	18		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96N16-18-unknown	AVQMAN...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161725
Q96N16-18-unknown	AVQMAN...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161726
Q96N16-18-unknown	AVQMAN...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161727
Q96N16-18-unknown	AVQMAN...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161728
Q96N16-18-unknown	AVQMAN...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161729
Q96N16-209-unknown	MDEIKG...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78325
Q96N16-209-unknown	MDEIKG...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109470
Q96N16-209-unknown	MDEIKG...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109471
Q96N16-209-unknown	MDEIKG...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109472
Q96N16-209-unknown	MDEIKG...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109473
Q96N16-209-unknown	MDEIKG...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109474

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLKFM	626	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KLKFM	626	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73943
...KLKFM	626	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73944

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)