Q99590: Protein SCAF11
Protein names | - Protein SCAF11 - CTD-associated SR protein 11 - Renal carcinoma antigen NY-REN-40 - SC35-interacting protein 1 - SR-related and CTD-associated factor 11 - SRSF2-interacting protein - Serine/arginine-rich splicing factor 2-interacting protein - Splicing factor, arginine/serine-rich 2-interacting protein - Splicing regulatory protein 129 - SRrp129 |
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Gene names | SCAF11 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q99590 |
16
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MKKKTVCTLN MGDKKYEDME GEENGDNTIS TGLLYSEADR CPICLNCLLE KEVGFPESCN
70 80 90 100 110 120
HVFCMTCILK WAETLASCPI DRKPFQAVFK FSALEGYVKV QVKKQLRETK DKKNENSFEK
130 140 150 160 170 180
QVSCHENSKS CIRRKAIVRE DLLSAKVCDL KWIHRNSLYS ETGGKKNAAI KINKPQRSNW
190 200 210 220 230 240
STNQCFRNFF SNMFSSVSHS GESSFTYRAY CTEFIEASEI SALIRQKRHE LELSWFPDTL
250 260 270 280 290 300
PGIGRIGFIP WNVETEVLPL ISSVLPRTIF PTSTISFEHF GTSCKGYALA HTQEGEEKKQ
310 320 330 340 350 360
TSGTSNTRGS RRKPAMTTPT RRSTRNTRAE TASQSQRSPI SDNSGCDAPG NSNPSLSVPS
370 380 390 400 410 420
SAESEKQTRQ APKRKSVRRG RKPPLLKKKL RSSVAAPEKS SSNDSVDEET AESDTSPVLE
430 440 450 460 470 480
KEHQPDVDSS NICTVQTHVE NQSANCLKSC NEQIEESEKH TANYDTEERV GSSSSESCAQ
490 500 510 520 530 540
DLPVLVGEEG EVKKLENTGI EANVLCLESE ISENILEKGG DPLEKQDQIS GLSQSEVKTD
550 560 570 580 590 600
VCTVHLPNDF PTCLTSESKV YQPVSCPLSD LSENVESVVN EEKITESSLV EITEHKDFTL
610 620 630 640 650 660
KTEELIESPK LESSEGEIIQ TVDRQSVKSP EVQLLGHVET EDVEIIATCD TFGNEDFNNI
670 680 690 700 710 720
QDSENNLLKN NLLNTKLEKS LEEKNESLTE HPRSTELPKT HIEQIQKHFS EDNNEMIPME
730 740 750 760 770 780
CDSFCSDQNE SEVEPSVNAD LKQMNENSVT HCSENNMPSS DLADEKVETV SQPSESPKDT
790 800 810 820 830 840
IDKTKKPRTR RSRFHSPSTT WSPNKDTPQE KKRPQSPSPR RETGKESRKS QSPSPKNESA
850 860 870 880 890 900
RGRKKSRSQS PKKDIARERR QSQSRSPKRD TTRESRRSES LSPRRETSRE NKRSQPRVKD
910 920 930 940 950 960
SSPGEKSRSQ SRERESDRDG QRRERERRTR KWSRSRSHSR SPSRCRTKSK SSSFGRIDRD
970 980 990 1000 1010 1020
SYSPRWKGRW ANDGWRCPRG NDRYRKNDPE KQNENTRKEK NDIHLDADDP NSADKHRNDC
1030 1040 1050 1060 1070 1080
PNWITEKINS GPDPRTRNPE KLKESHWEEN RNENSGNSWN KNFGSGWVSN RGRGRGNRGR
1090 1100 1110 1120 1130 1140
GTYRSSFAYK DQNENRWQNR KPLSGNSNSS GSESFKFVEQ QSYKRKSEQE FSFDTPADRS
1150 1160 1170 1180 1190 1200
GWTSASSWAV RKTLPADVQN YYSRRGRNSS GPQSGWMKQE EETSGQDSSL KDQTNQQVDG
1210 1220 1230 1240 1250 1260
SQLPINMMQP QMNVMQQQMN AQHQPMNIFP YPVGVHAPLM NIQRNPFNIH PQLPLHLHTG
1270 1280 1290 1300 1310 1320
VPLMQVATPT SVSQGLPPPP PPPPPSQQVN YIASQPDGKQ LQGIPSSSHV SNNMSTPVLP
1330 1340 1350 1360 1370 1380
APTAAPGNTG MVQGPSSGNT SSSSHSKASN AAVKLAESKV SVAVEASADS SKTDKKLQIQ
1390 1400 1410 1420 1430 1440
EKAAQEVKLA IKPFYQNKDI TKEEYKEIVR KAVDKVCHSK SGEVNSTKVA NLVKAYVDKY
1450 1460
KYSRKGSQKK TLEEPVSTEK NIG
Isoforms
- Isoform 2 of Protein SCAF11Sequence View
10 20 30 40 50 60
MKKKTVCTLN MGDKKYEDME GEENGDNTIS TGLLYSEADR CPICLNCLLE KEVGFPESCN
70 80 90 100 110 120
HVFCMTCILK WAETLASCPI DRKPFQAVFK FSALEGYVKV QVKKQLRETK DKKNENSFEK
130 140 150 160 170 180
QVSCHENSKS CIRRKAIVRE DLLSAKVCDL KWIHRNSLYS ETGGKKNAAI KINKPQRSNW
190 200 210 220 230 240
STNQCFRNFF SNMFSSVSHS GESSFTYRAY CTEFIEASEI SALIRQKRHE LELSWFPDTL
250 260 270 280 290 300
PGIGRIGFIP WNVETEVLPL ISSVLPRTIF PTSTISFEHF GTSCKGYALA HTQEGEEKKQ
310 320 330 340 350 360
TSGTSNTRGS RRKPAMTTPT RRSTRNTRAE TASQSQRSPI SDNSGCDAPG NSNPSLSVPS
370 380 390 400 410 420
SAESEKQTRQ APKRKSVRRG RKPPLLKKKL RSSVAAPEKS SSNDSVDEET AESDTSPVLE
430 440 450 460 470 480
KEHQPDVDSS NICTVQTHVE NQSANCLKSC NEQIEESEKH TANYDTEERV GSSSSESCAQ
490 500 510 520 530 540
DLPVLVGEEG EVKKLENTGI EANVLCLESE ISENILEKGG DPLEKQDQIS GLSQSEVKTD
550 560 570 580 590 600
VCTVHLPNDF PTCLTSESKV YQPVSCPLSD LSENVESVVN EEKITESSLV EITEHKDFTL
610 620 630 640 650 660
KTEELIESPK LESSEGEIIQ TVDRQSVKSP EVQLLGHVET EDVEIIATCD TFGNEDFNNI
670 680 690 700 710 720
QDSENNLLKN NLLNTKLEKS LEEKNESLTE HPRSTELPKT HIEQIQKHFS EDNNEMIPME
730 740 750 760 770 780
CDSFCSDQNE SEVEPSVNAD LKQMNENSVT HCSENNMPSS DLADEKVETV SQPSESPKDT
790 800 810 820 830 840
IDKTKKPRTR RSRFHSPSTT WSPNKDTPQE KKRPQSPSPR RETGKESRKS QSPSPKNESA
850 860 870 880 890 900
RGRKKSRSQS PKKDIARERR QSQSRSPKRD TTRESRRSES LSPRRETSRE NKRSQPRVKD
910 920 930 940 950 960
SSPGEKSRSQ SRERESDRDG QRRERERRTR KWSRSRSHSR SPSRCRTKSK SSSFGRIDRD
970 980 990 1000 1010 1020
SYSPRWKGRW ANDGWRCPRG NDRYRKNDPE KQNENTRKEK NDIHLDADDP NSADKHRNDC
1030 1040 1050 1060 1070 1080
PNWITEKINS GPDPRTRNPE KLKESHWEEN RNENSGNSWN KNFGSGWVSN RGRGRGNRGR
1090 1100 1110 1120 1130 1140
GTYRSSFAYK DQNENRWQNR KPLSGNSNSS GSESFKFVEQ QSYKRKSEQE FSFDTPADRS
1150 1160 1170 1180 1190 1200
GWTSASSWAV RKTLPADVQN YYSRRGRNSS GPQSGWMKQE EETSGQDSSL KDQTNQQVDG
1210 1220 1230 1240 1250 1260
SQLPINMMQP QMNVMQQQMN AQHQPMNIFP YPVGVHAPLM NIQRNPFNIH PQLPLHLHTG
1270 1280 1290 1300 1310 1320
VPLMQVATPT SVSQGLPPPP PPPPPSQQVN YIASQPDGKQ LQGIPSSSHV SNNMSTPVLP
1330 1340 1350 1360 1370 1380
APTAAPGNTG MVQGPSSGNT SSSSHSKASN AAVKLAESKV SVAVEASADS SKTDKKLQIQ
1390 1400 1410 1420 1430 1440
EKAAQEVKLA IKPFYQNKDI TKEEYKEIVR KAVDKVCHSK SGEVNSTKVA NLVKAYVDKY
1450 1460
KYSRKGSQKK TLEEPVSTEK NIG
Protein Neighborhood
Domains & Features
16 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q99590-1-unknown | MKKKTV... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q99590-288- | ALAHTQ... | 288 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q99590-288- | ALAHTQ... | 288 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q99590-288- | ALAHTQ... | 288 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q99590-288- | ALAHTQ... | 288 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q99590-288- | ALAHTQ... | 288 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q99590-288- | ALAHTQ... | 288 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q99590-288- | ALAHTQ... | 288 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q99590-290- | AHTQEG... | 290 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q99590-316-unknown | MTTPTR... | 316 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt88969 | |||
Q99590-361-unknown | SAESEK... | 361 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14892 | |||
Q99590-361-unknown | SAESEK... | 361 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt138817 | |||
Q99590-408-unknown | EETAES... | 408 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q99590-408-unknown | EETAES... | 408 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162108 | |||
Q99590-723- | SFCSDQ... | 723 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q99590-723- | SFCSDQ... | 723 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q99590-723-unknown | SFCSDQ... | 723 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172312 | |||
Q99590-801-unknown | WSPNKD... | 801 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q99590-801-unknown | WSPNKD... | 801 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160276 | |||
Q99590-817-unknown | PSPRRE... | 817 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q99590-817-unknown | PSPRRE... | 817 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160278 | |||
Q99590-1116-unknown | KFVEQQ... | 1116 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169186 | |||
Q99590-1116- | KFVEQQ... | 1116 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q99590-1132-unknown | SFDTPA... | 1132 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169188 | |||
Q99590-1132- | SFDTPA... | 1132 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q99590-1315-unknown | STPVLP... | 1315 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168076 | |||
Q99590-1315- | STPVLP... | 1315 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LSVPSS | 360 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14892 | |||
...LSVPSS | 360 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121876 | |||
...EKNIG | 1463 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...EKNIG | 1463 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt84587 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAM_HUMAN | 360 | VPSS.|.SAES | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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