Q99661: Kinesin-like protein KIF2C

General Information

Protein names	- Kinesin-like protein KIF2C - Kinesin-like protein 6 - Mitotic centromere-associated kinesin - MCAK
Gene names	KIF2C
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99661

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAMDSSLQAR LFPGLAIKIQ RSNGLIHSAN VRTVNLEKSC VSVEWAEGGA TKGKEIDFDD
        70         80         90        100        110        120
VAAINPELLQ LLPLHPKDNL PLQENVTIQK QKRRSVNSKI PAPKESLRSR STRMSTVSEL
       130        140        150        160        170        180
RITAQENDME VELPAAANSR KQFSVPPAPT RPSCPAVAEI PLRMVSEEME EQVHSIRGSS
       190        200        210        220        230        240
SANPVNSVRR KSCLVKEVEK MKNKREEKKA QNSEMRMKRA QEYDSSFPNW EFARMIKEFR
       250        260        270        280        290        300
ATLECHPLTM TDPIEEHRIC VCVRKRPLNK QELAKKEIDV ISIPSKCLLL VHEPKLKVDL
       310        320        330        340        350        360
TKYLENQAFC FDFAFDETAS NEVVYRFTAR PLVQTIFEGG KATCFAYGQT GSGKTHTMGG
       370        380        390        400        410        420
DLSGKAQNAS KGIYAMASRD VFLLKNQPCY RKLGLEVYVT FFEIYNGKLF DLLNKKAKLR
       430        440        450        460        470        480
VLEDGKQQVQ VVGLQEHLVN SADDVIKMID MGSACRTSGQ TFANSNSSRS HACFQIILRA
       490        500        510        520        530        540
KGRMHGKFSL VDLAGNERGA DTSSADRQTR MEGAEINKSL LALKECIRAL GQNKAHTPFR
       550        560        570        580        590        600
ESKLTQVLRD SFIGENSRTC MIATISPGIS SCEYTLNTLR YADRVKELSP HSGPSGEQLI
       610        620        630        640        650        660
QMETEEMEAC SNGALIPGNL SKEEEELSSQ MSSFNEAMTQ IRELEEKAME ELKEIIQQGP
       670        680        690        700        710        720
DWLELSEMTE QPDYDLETFV NKAESALAQQ AKHFSALRDV IKALRLAMQL EEQASRQISS

KKRPQ

Isoforms

- Isoform 2 of Kinesin-like protein KIF2C

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99661-2-unknown	MAMDSS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99661-2-Acetylation	AMDSSL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99661-2-Acetylation	AMDSSL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q99661-2-Acetylation	AMDSSL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q99661-95-unknown	SVNSKI...	95		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172695
Q99661-95-	SVNSKI...	95			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99661-95-	SVNSKI...	95			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99661-180-unknown	SSANPV...	180		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13142
Q99661-180-unknown	SSANPV...	180		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143729
Q99661-181-	SANPVN...	181			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99661-181-unknown	SANPVN...	181		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168592

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SIRGSS	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13142
...SIRGSS	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126972
...KKRPQ	725	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KKRPQ	725	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74605

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	179	RGSS.\|.SSAN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)