Q99704: Docking protein 1

General Information

Protein names	- Docking protein 1 - Downstream of tyrosine kinase 1 - p62(dok) - pp62
Gene names	DOK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99704

6 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Docking protein 1 - Isoform 3 of Docking protein 1

Sequence View

        10         20         30         40         50         60
MDGAVMEGPL FLQSQRFGTK RWRKTWAVLY PASPHGVARL EFFDHKGSSS GGGRGSSRRL
        70         80         90        100        110        120
DCKVIRLAEC VSVAPVTVET PPEPGATAFR LDTAQRSHLL AADAPSSAAW VQTLCRNAFP
       130        140        150        160        170        180
KGSWTLAPTD NPPKLSALEM LENSLYSPTW EGSQFWVTVQ RTEAAERCGL HGSYVLRVEA
       190        200        210        220        230        240
ERLTLLTVGA QSQILEPLLS WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTAQGND
       250        260        270        280        290        300
IFQAVETAIH RQKAQGKAGQ GHDVLRADSH EGEVAEGKLP SPPGPQELLD SPPALYAEPL
       310        320        330        340        350        360
DSLRIAPCPS QDSLYSDPLD STSAQAGEGV QRKKPLYWDL YEHAQQQLLK AKLTDPKEDP
       370        380        390        400        410        420
IYDEPEGLAP VPPQGLYDLP REPKDAWWCQ ARVKEEGYEL PYNPATDDYA VPPPRSTKPL
       430        440        450        460        470        480
LAPKPQGPAF PEPGTATGSG IKSHNSALYS QVQKSGASGS WDCGLSRVGT DKTGVKSEGS

T         10         20         30         40         50         60
MDGAVMEGPL FLQSQRFGTK RWRKTWAVLY PASPHGVARL EFFDHKGSSS GGGRGSSRRL
        70         80         90        100        110        120
DCKVIRLAEC VSVAPVTVET PPEPGATAFR LDTAQRSHLL AADAPSSAAW VQTLCRNAFP
       130        140        150        160        170        180
KGSWTLAPTD NPPKLSALEM LENSLYSPTW EGSQFWVTVQ RTEAAERCGL HGSYVLRVEA
       190        200        210        220        230        240
ERLTLLTVGA QSQILEPLLS WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTAQGND
       250        260        270        280        290        300
IFQAVETAIH RQKAQGKAGQ GHDVLRADSH EGEVAEGKLP SPPGPQELLD SPPALYAEPL
       310        320        330        340        350        360
DSLRIAPCPS QDSLYSDPLD STSAQAGEGV QRKKPLYWDL YEHAQQQLLK AKLTDPKEDP
       370        380        390        400        410        420
IYDEPEGLAP VPPQGLYDLP REPKDAWWCQ ARVKEEGYEL PYNPATDDYA VPPPRSTKPL
       430        440        450        460        470        480
LAPKPQGPAF PEPGTATGSG IKSHNSALYS QVQKSGASGS WDCGLSRVGT DKTGVKSEGS

T

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99704-1-unknown	MDGAVM...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73131
Q99704-1-Acetylation	MDGAVM...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99704-1-Acetylation	MDGAVM...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q99704-1-Acetylation	MDGAVM...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108511
Q99704-140-unknown	MLENSL...	140		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73132
Q99704-313-unknown	SLYSDP...	313		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13147
Q99704-313-unknown	SLYSDP...	313		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145664
Q99704-367-	GLAPVP...	367			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q99704-367-	GLAPVP...	367			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99704-367-	GLAPVP...	367			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99704-367-	GLAPVP...	367			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99704-367-	GLAPVP...	367			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99704-367-unknown	GLAPVP...	367		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165144

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...CPSQDS	312	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13147
...CPSQDS	312	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128962
...SEGST	481		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SEGST	481	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SEGST	481	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68750
...SEGST	481		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	312	SQDS.\|.SLYS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)