Q9BQ39: ATP-dependent RNA helicase DDX50

General Information

Protein names	- ATP-dependent RNA helicase DDX50 - 3.6.4.13 - DEAD box protein 50 - Gu-beta - Nucleolar protein Gu2
Gene names	DDX50
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BQ39

8 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGKLLWGDI MELEAPLEES ESQKKERQKS DRRKSRHHYD SDEKSETREN GVTDDLDAPK
        70         80         90        100        110        120
AKKSKMKEKL NGDTEEGFNR LSDEFSKSHK SRRKDLPNGD IDEYEKKSKR VSSLDTSTHK
       130        140        150        160        170        180
SSDNKLEETL TREQKEGAFS NFPISEETIK LLKGRGVTYL FPIQVKTFGP VYEGKDLIAQ
       190        200        210        220        230        240
ARTGTGKTFS FAIPLIERLQ RNQETIKKSR SPKVLVLAPT RELANQVAKD FKDITRKLSV
       250        260        270        280        290        300
ACFYGGTSYQ SQINHIRNGI DILVGTPGRI KDHLQSGRLD LSKLRHVVLD EVDQMLDLGF
       310        320        330        340        350        360
AEQVEDIIHE SYKTDSEDNP QTLLFSATCP QWVYKVAKKY MKSRYEQVDL VGKMTQKAAT
       370        380        390        400        410        420
TVEHLAIQCH WSQRPAVIGD VLQVYSGSEG RAIIFCETKK NVTEMAMNPH IKQNAQCLHG
       430        440        450        460        470        480
DIAQSQREIT LKGFREGSFK VLVATNVAAR GLDIPEVDLV IQSSPPQDVE SYIHRSGRTG
       490        500        510        520        530        540
RAGRTGICIC FYQPRERGQL RYVEQKAGIT FKRVGVPSTM DLVKSKSMDA IRSLASVSYA
       550        560        570        580        590        600
AVDFFRPSAQ RLIEEKGAVD ALAAALAHIS GASSFEPRSL ITSDKGFVTM TLESLEEIQD
       610        620        630        640        650        660
VSCAWKELNR KLSSNAVSQI TRMCLLKGNM GVCFDVPTTE SERLQAEWHD SDWILSVPAK
       670        680        690        700        710        720
LPEIEEYYDG NTSSNSRQRS GWSSGRSGRS GRSGGRSGGR SGRQSRQGSR SGSRQDGRRR
       730
SGNRNRSRSG GHKRSFD

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BQ39-1-unknown	MPGKLL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BQ39-11-unknown	MELEAP...	11	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9BQ39-14-unknown	EAPLEE...	14	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14910
Q9BQ39-71-unknown	NGDTEE...	71	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14911
Q9BQ39-148-unknown	TIKLLK...	148	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13157
Q9BQ39-223-	LANQVA...	223		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9BQ39-223-	LANQVA...	223		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9BQ39-223-	LANQVA...	223		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9BQ39-381-unknown	VLQVYS...	381	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13158
Q9BQ39-563-unknown	AAALAH...	563	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14912

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DIMELE	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14910
...MKEKLN	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14911
...PISEET	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13157
...AVIGDV	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13158
...AVDALA	562	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14912
...KRSFD	737	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	13	MELE.\|.EAPL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	70	EKLN.\|.NGDT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	147	SEET.\|.TIKL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	380	IGDV.\|.VLQV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	562	DALA.\|.AAAL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)